AutismKB 2.0

Annotation Detail for FBXL12


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Basic Information Top
Gene Symbol:FBXL12 ( FLJ20188,Fbl12 )
Gene Full Name: F-box and leucine-rich repeat protein 12
Band: 19p13.2
Quick LinksEntrez ID:54850; OMIM: 609079; Uniprot ID:FXL12_HUMAN; ENSEMBL ID: ENSG00000127452; HGNC ID: 13611
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus22 / 56401239
neonate2 / 3109764
infant3 / 23620127
juvenile2 / 5555635
adult72 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor5 / 26384518
glioma6 / 10688356
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia10 / 95842104
liver tumor5 / 9635951
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal127 / 336030737
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone2 / 7165527
bone marrow1 / 4880120
brain33 / 110098929
cervix5 / 48171103
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus2 / 2020998
eye3 / 21105414
heart3 / 8962633
intestine8 / 23447234
kidney3 / 21177714
larynx0 / 241450 
liver6 / 20774328
lung17 / 33697450
lymph1 / 4427022
lymph node8 / 9161087
mammary gland5 / 15327132
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta19 / 28082567
prostate7 / 18934536
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach12 / 96619124
testis7 / 33044221
thymus15 / 81131184
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220127_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts103.95
Adipocyte37.7
AdrenalCortex44.2
Adrenalgland33.2
Amygdala36.65
Appendix38.4
AtrioventricularNode26.4
BDCA4+_DentriticCells69.7
Bonemarrow45.95
BronchialEpithelialCells35.55
CD105+_Endothelial30.55
CD14+_Monocytes51.5
CD19+_BCells(neg._sel.)43.25
CD33+_Myeloid40.35
CD34+38.8
CD4+_Tcells66
CD56+_NKCells40.65
CD71+_EarlyErythroid15.9
CD8+_Tcells84.25
CardiacMyocytes45.85
Caudatenucleus28.15
Cerebellum29.2
CerebellumPeduncles38.6
CiliaryGanglion22.35
CingulateCortex36.1
Colorectaladenocarcinoma36.35
DorsalRootGanglion26.95
FetalThyroid44.9
Fetalbrain35.05
Fetalliver30.2
Fetallung42.65
GlobusPallidus21.7
Heart47.85
Hypothalamus36.2
Kidney33.55
Leukemia_chronicMyelogenousK-56256.35
Leukemia_promyelocytic-HL-6036.25
Leukemialymphoblastic(MOLT-4)64.8
Liver43.8
Lung112.35
Lymphnode43
Lymphoma_burkitts(Daudi)44.65
Lymphoma_burkitts(Raji)50
MedullaOblongata32.1
OccipitalLobe29.5
OlfactoryBulb26.5
Ovary27
Pancreas28.3
PancreaticIslet37.35
ParietalLobe37.4
Pituitary39
Placenta80.65
Pons42.1
PrefrontalCortex42.6
Prostate53.5
Salivarygland27.85
SkeletalMuscle42.2
Skin26.7
SmoothMuscle51.6
Spinalcord34.05
SubthalamicNucleus31
SuperiorCervicalGanglion54.1
TemporalLobe32.7
Testis57
TestisGermCell30.8
TestisIntersitial32.6
TestisLeydigCell34.2
TestisSeminiferousTubule36.5
Thalamus35.8
Thymus394.7
Thyroid79
Tongue34.6
Tonsil44.7
Trachea30.45
TrigeminalGanglion40.65
Uterus45.6
UterusCorpus36.8
WholeBlood53.7
Wholebrain29.4
colon51.35
pineal_day29.16
pineal_night29.3
retina42.125
small_intestine48.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P78557
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.94 ± 0.7
Basal Forebrain3.58 ± 0.67
Basal Part of Pons3.64 ± 0.53
Cerebellar Cortex4.2 ± 0.37
Cerebellar Nuclei3.65 ± 0.47
Claustrum3.79 ± 0.8
Epithalamus3.73 ± 0.34
Frontal Lobe3.68 ± 0.51
Globus Pallidus3.72 ± 0.56
Hypothalamus3.71 ± 0.4
Insula3.6 ± 0.47
Limbic Lobe3.85 ± 0.6
Mesencephalon3.68 ± 0.6
Myelencephalon3.76 ± 0.55
Occipital Lobe4.14 ± 0.57
Parietal Lobe3.82 ± 0.58
Pontine Tegmentum3.87 ± 0.68
Striatum3.34 ± 0.62
Subthalamus3.79 ± 0.45
Temporal Lobe3.89 ± 0.54
Thalamus3.75 ± 0.56
White Matter3.62 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxl12CBCerebellum4.5
6.09
Fbxl12CTXCerebral cortex18.63
12.8
Fbxl12HIPHippocampal region10.69
10.7
Fbxl12HPFHippocampal formation8.48
7.58
Fbxl12HYHypothalamus7
5.13
Fbxl12LSXLateral septal complex6.02
4.21
Fbxl12MBMidbrain5.93
5.42
Fbxl12MYMedulla4.15
3.82
Fbxl12OLFOlfactory bulb8.56
6.39
Fbxl12PPons4.63
4.6
Fbxl12PALPallidum4.19
3.07
Fbxl12RHPRetrohippocampal region5.06
3.53
Fbxl12sAMYStriatum-like amygdalar nuclei5.31
3.34
Fbxl12STRStriatum4.43
2.97
Fbxl12STRdStriatum dorsal region2.75
1.94
Fbxl12STRvStriatum ventral region9.6
5.8
Fbxl12THThalamus5.54
5.01
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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