AutismKB 2.0

Annotation Detail for SLX1A


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Basic Information Top
Gene Symbol:SLX1A ( GIYD1,GIYD2 )
Gene Full Name: SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Band: 16p11.2
Quick LinksEntrez ID:548593; OMIM: NA; Uniprot ID:SLX1_HUMAN; ENSEMBL ID: ENSG00000132207; HGNC ID: 20922
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218317_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts171
Adipocyte9.45
AdrenalCortex12.2
Adrenalgland7.6
Amygdala11.45
Appendix5.9
AtrioventricularNode5.25
BDCA4+_DentriticCells118.7
Bonemarrow9.35
BronchialEpithelialCells23.55
CD105+_Endothelial217.45
CD14+_Monocytes196.25
CD19+_BCells(neg._sel.)61.65
CD33+_Myeloid158.25
CD34+122.05
CD4+_Tcells151.25
CD56+_NKCells101
CD71+_EarlyErythroid105.6
CD8+_Tcells96.8
CardiacMyocytes26.1
Caudatenucleus8.6
Cerebellum5.25
CerebellumPeduncles20.25
CiliaryGanglion5.6
CingulateCortex7.3
Colorectaladenocarcinoma14.85
DorsalRootGanglion6.45
FetalThyroid35.65
Fetalbrain9.15
Fetalliver8.15
Fetallung7.6
GlobusPallidus6.25
Heart23.25
Hypothalamus10
Kidney6.7
Leukemia_chronicMyelogenousK-56216.9
Leukemia_promyelocytic-HL-6035.55
Leukemialymphoblastic(MOLT-4)70.45
Liver101.95
Lung32.6
Lymphnode22.45
Lymphoma_burkitts(Daudi)16.25
Lymphoma_burkitts(Raji)28.45
MedullaOblongata7.25
OccipitalLobe7.95
OlfactoryBulb6.75
Ovary5.1
Pancreas8.95
PancreaticIslet10.45
ParietalLobe9.15
Pituitary12.2
Placenta34.95
Pons7.75
PrefrontalCortex22.15
Prostate20.45
Salivarygland7.4
SkeletalMuscle8.6
Skin6.15
SmoothMuscle24
Spinalcord12.85
SubthalamicNucleus15
SuperiorCervicalGanglion8.5
TemporalLobe7.45
Testis7
TestisGermCell6.55
TestisIntersitial7.55
TestisLeydigCell7.05
TestisSeminiferousTubule6.65
Thalamus10.9
Thymus18.05
Thyroid28.25
Tongue9.8
Tonsil13.8
Trachea6.35
TrigeminalGanglion6.5
Uterus6.75
UterusCorpus6.2
WholeBlood39.8
Wholebrain6.8
colon9.35
pineal_day13.22
pineal_night10.24
retina11.175
small_intestine33.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2170_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.79 ± 0.4
Basal Forebrain4.35 ± 0.2
Basal Part of Pons4.75 ± 0.31
Cerebellar Cortex4.81 ± 0.32
Cerebellar Nuclei4.54 ± 0.42
Claustrum4.63 ± 0.66
Epithalamus4.29 ± 0.35
Frontal Lobe4.64 ± 0.41
Globus Pallidus4.43 ± 0.28
Hypothalamus4.34 ± 0.44
Insula4.68 ± 0.35
Limbic Lobe4.55 ± 0.44
Mesencephalon4.48 ± 0.48
Myelencephalon4.61 ± 0.4
Occipital Lobe4.42 ± 0.39
Parietal Lobe4.49 ± 0.38
Pontine Tegmentum4.51 ± 0.46
Striatum4.15 ± 0.38
Subthalamus4.62 ± 0.14
Temporal Lobe4.7 ± 0.36
Thalamus4.71 ± 0.39
White Matter5.1 ± 0.53
Mouse Brain ISH
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018