AutismKB 2.0

Annotation Detail for DPP8


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Basic Information Top
Gene Symbol:DPP8 ( DP8,DPRP1,FLJ14920,FLJ20283,MGC26191,MSTP141 )
Gene Full Name: dipeptidyl-peptidase 8
Band: 15q22.31
Quick LinksEntrez ID:54878; OMIM: 606819; Uniprot ID:DPP8_HUMAN; ENSEMBL ID: ENSG00000074603; HGNC ID: 16490
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus21 / 56401237
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor12 / 26384545
glioma2 / 10688318
head and neck tumor19 / 136302139
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal131 / 336030738
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood6 / 12347848
bone5 / 7165569
bone marrow1 / 4880120
brain53 / 110098948
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine2 / 2344728
kidney7 / 21177733
larynx2 / 2414582
liver3 / 20774314
lung7 / 33697420
lymph0 / 442700 
lymph node10 / 91610109
mammary gland4 / 15327126
mouth12 / 67052178
muscle4 / 10771537
nerve0 / 157680 
ovary1 / 1020519
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate3 / 18934515
salivary gland6 / 20155297
skin2 / 2105749
spleen4 / 5395274
stomach3 / 9661931
testis45 / 330442136
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220939_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts252
Adipocyte26.75
AdrenalCortex14.05
Adrenalgland9.2
Amygdala74.8
Appendix8.7
AtrioventricularNode8.15
BDCA4+_DentriticCells275.45
Bonemarrow8.55
BronchialEpithelialCells46.3
CD105+_Endothelial160.5
CD14+_Monocytes230.75
CD19+_BCells(neg._sel.)261.3
CD33+_Myeloid523.2
CD34+291.8
CD4+_Tcells368.2
CD56+_NKCells429.35
CD71+_EarlyErythroid71.15
CD8+_Tcells344.95
CardiacMyocytes29.75
Caudatenucleus8.6
Cerebellum6
CerebellumPeduncles27.95
CiliaryGanglion8.65
CingulateCortex100
Colorectaladenocarcinoma11.95
DorsalRootGanglion13.65
FetalThyroid38.4
Fetalbrain8.9
Fetalliver15.1
Fetallung9.4
GlobusPallidus84.35
Heart7.3
Hypothalamus24.4
Kidney8.45
Leukemia_chronicMyelogenousK-56211.8
Leukemia_promyelocytic-HL-6011.7
Leukemialymphoblastic(MOLT-4)21.25
Liver8.05
Lung7.4
Lymphnode10.9
Lymphoma_burkitts(Daudi)17.25
Lymphoma_burkitts(Raji)10.8
MedullaOblongata121.7
OccipitalLobe108.25
OlfactoryBulb42.95
Ovary20.6
Pancreas20.4
PancreaticIslet50.2
ParietalLobe84.9
Pituitary15.35
Placenta45.5
Pons28.1
PrefrontalCortex173.65
Prostate46.05
Salivarygland27.6
SkeletalMuscle10.3
Skin16.9
SmoothMuscle49.2
Spinalcord7.2
SubthalamicNucleus97.3
SuperiorCervicalGanglion10
TemporalLobe35.35
Testis55.7
TestisGermCell228.3
TestisIntersitial169.95
TestisLeydigCell122.75
TestisSeminiferousTubule110.8
Thalamus23.4
Thymus70.05
Thyroid25.55
Tongue12.75
Tonsil52.65
Trachea27.6
TrigeminalGanglion10.3
Uterus30.1
UterusCorpus7.8
WholeBlood46.6
Wholebrain34.15
colon63.2
pineal_day131.06
pineal_night127.94
retina96.65
small_intestine41.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P130066
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.52 ± 0.41
Basal Forebrain5.34 ± 0.29
Basal Part of Pons5.56 ± 0.28
Cerebellar Cortex5.19 ± 0.34
Cerebellar Nuclei5.18 ± 0.49
Claustrum5.5 ± 0.36
Epithalamus5.24 ± 0.53
Frontal Lobe5.39 ± 0.37
Globus Pallidus5.55 ± 0.28
Hypothalamus5.04 ± 0.38
Insula5.19 ± 0.43
Limbic Lobe5.4 ± 0.36
Mesencephalon5.36 ± 0.34
Myelencephalon5.39 ± 0.37
Occipital Lobe5.77 ± 0.29
Parietal Lobe5.52 ± 0.35
Pontine Tegmentum5.43 ± 0.46
Striatum5.37 ± 0.37
Subthalamus5.59 ± 0.64
Temporal Lobe5.31 ± 0.38
Thalamus5.51 ± 0.44
White Matter4.68 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dpp8CBCerebellum18.12
20.76
Dpp8CTXCerebral cortex52.75
43.81
Dpp8HIPHippocampal region28.99
42.6
Dpp8HPFHippocampal formation30.57
37.12
Dpp8HYHypothalamus7.64
5.96
Dpp8LSXLateral septal complex12.63
9.31
Dpp8MBMidbrain10.98
11.05
Dpp8MYMedulla19.07
22.68
Dpp8OLFOlfactory bulb37.82
33.87
Dpp8PPons15.63
18.26
Dpp8PALPallidum8.94
8.39
Dpp8RHPRetrohippocampal region34.86
30.11
Dpp8sAMYStriatum-like amygdalar nuclei6.7
5.34
Dpp8STRStriatum13.3
10.18
Dpp8STRdStriatum dorsal region13.95
10.88
Dpp8STRvStriatum ventral region15.8
11.2
Dpp8THThalamus17.46
17.91
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DPP8_HUMAN_79 9 79 87 APHDFMFVK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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