AutismKB 2.0

Annotation Detail for WHSC1L1


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Basic Information Top
Gene Symbol:WHSC1L1 ( DKFZp667H044,FLJ20353,MGC126766,MGC142029,NSD3,pp14328 )
Gene Full Name: Wolf-Hirschhorn syndrome candidate 1-like 1
Band: 8p11.2
Quick LinksEntrez ID:54904; OMIM: 607083; Uniprot ID:NSD3_HUMAN; ENSEMBL ID: ENSG00000147548; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus29 / 56401251
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor1 / 3436629
chondrosarcoma10 / 82823120
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor16 / 26384560
glioma3 / 10688328
head and neck tumor8 / 13630258
kidney tumor0 / 689590 
leukemia10 / 95842104
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal141 / 336030741
ovarian tumor5 / 7668265
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood10 / 12347880
bone7 / 7165597
bone marrow4 / 4880181
brain38 / 110098934
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus1 / 2020949
eye12 / 21105456
heart0 / 896260 
intestine2 / 2344728
kidney7 / 21177733
larynx2 / 2414582
liver7 / 20774333
lung18 / 33697453
lymph0 / 442700 
lymph node11 / 91610120
mammary gland12 / 15327178
mouth3 / 6705244
muscle4 / 10771537
nerve0 / 157680 
ovary5 / 10205148
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta16 / 28082556
prostate4 / 18934521
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis14 / 33044242
thymus2 / 8113124
thyroid4 / 4747384
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221248_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.1
Adipocyte7.6
AdrenalCortex8.8
Adrenalgland6.85
Amygdala8.2
Appendix9.6
AtrioventricularNode7.05
BDCA4+_DentriticCells7.85
Bonemarrow8.3
BronchialEpithelialCells7.95
CD105+_Endothelial7.55
CD14+_Monocytes8.1
CD19+_BCells(neg._sel.)8.2
CD33+_Myeloid9.8
CD34+9.15
CD4+_Tcells8.9
CD56+_NKCells8.8
CD71+_EarlyErythroid7.4
CD8+_Tcells7.6
CardiacMyocytes11.15
Caudatenucleus7
Cerebellum6.35
CerebellumPeduncles9.25
CiliaryGanglion6.75
CingulateCortex8.1
Colorectaladenocarcinoma7.9
DorsalRootGanglion7.45
FetalThyroid7.55
Fetalbrain8.2
Fetalliver7.3
Fetallung6.3
GlobusPallidus5.9
Heart10.7
Hypothalamus8.2
Kidney6.65
Leukemia_chronicMyelogenousK-5627.05
Leukemia_promyelocytic-HL-607.45
Leukemialymphoblastic(MOLT-4)5.9
Liver11.5
Lung8.4
Lymphnode6.8
Lymphoma_burkitts(Daudi)10.1
Lymphoma_burkitts(Raji)12.55
MedullaOblongata7.15
OccipitalLobe6.9
OlfactoryBulb6.15
Ovary11.4
Pancreas6.3
PancreaticIslet8.35
ParietalLobe8.6
Pituitary9.2
Placenta7.4
Pons7.6
PrefrontalCortex9.8
Prostate9
Salivarygland6.6
SkeletalMuscle10.9
Skin8.65
SmoothMuscle8.7
Spinalcord8.3
SubthalamicNucleus7.25
SuperiorCervicalGanglion13.55
TemporalLobe9.05
Testis6.65
TestisGermCell6.05
TestisIntersitial6.5
TestisLeydigCell7.8
TestisSeminiferousTubule6.7
Thalamus7.95
Thymus6.1
Thyroid9.55
Tongue8.05
Tonsil8.9
Trachea6.5
TrigeminalGanglion9.9
Uterus6.3
UterusCorpus10.4
WholeBlood8.45
Wholebrain6.25
colon7.85
pineal_day9.28
pineal_night9.42
retina9.3
small_intestine7.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P317719
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.45 ± 0.31
Basal Forebrain6.52 ± 0.21
Basal Part of Pons6.29 ± 0.23
Cerebellar Cortex6.61 ± 0.15
Cerebellar Nuclei5.88 ± 0.24
Claustrum6.37 ± 0.5
Epithalamus6.52 ± 0.22
Frontal Lobe6.28 ± 0.34
Globus Pallidus5.71 ± 0.29
Hypothalamus6.5 ± 0.24
Insula6.47 ± 0.19
Limbic Lobe6.3 ± 0.35
Mesencephalon6.13 ± 0.45
Myelencephalon6.25 ± 0.37
Occipital Lobe6.31 ± 0.41
Parietal Lobe6.36 ± 0.25
Pontine Tegmentum6.37 ± 0.33
Striatum5.88 ± 0.28
Subthalamus6.32 ± 0.56
Temporal Lobe6.45 ± 0.26
Thalamus6.16 ± 0.29
White Matter5.93 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Whsc1l1CBCerebellum24
22.07
Whsc1l1CTXCerebral cortex50
40.35
Whsc1l1HIPHippocampal region48.34
85.86
Whsc1l1HPFHippocampal formation45.26
63.47
Whsc1l1HYHypothalamus6.88
5.61
Whsc1l1LSXLateral septal complex11.69
8.67
Whsc1l1MBMidbrain14.72
14.25
Whsc1l1MYMedulla12.77
14.06
Whsc1l1OLFOlfactory bulb33.54
28.64
Whsc1l1PPons17.61
18.09
Whsc1l1PALPallidum7.16
5.99
Whsc1l1RHPRetrohippocampal region40.59
34.86
Whsc1l1sAMYStriatum-like amygdalar nuclei15.54
12.05
Whsc1l1STRStriatum7.88
6.14
Whsc1l1STRdStriatum dorsal region5.87
4.72
Whsc1l1STRvStriatum ventral region8.92
6.46
Whsc1l1THThalamus14.18
11.79
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00078371 25 424 448 SVLNTQPEQTNAGEVASSLSSTEIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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