AutismKB 2.0

Annotation Detail for RPP25


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Basic Information Top
Gene Symbol:RPP25 ( FLJ20374 )
Gene Full Name: ribonuclease P/MRP 25kDa subunit
Band: 15q24.2
Quick LinksEntrez ID:54913; OMIM: NA; Uniprot ID:RPP25_HUMAN; ENSEMBL ID: ENSG00000178718; HGNC ID: 30361
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus9 / 56401215
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor6 / 34366174
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor17 / 103127164
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal75 / 336030722
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS23 / 125680183
prostate cancer2 / 10268019
retinoblastoma15 / 46356323
skin tumor32 / 124949256
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder3 / 29757100
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain28 / 110098925
cervix11 / 48171228
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye25 / 211054118
heart2 / 8962622
intestine16 / 23447268
kidney1 / 2117774
larynx3 / 24145124
liver1 / 2077434
lung25 / 33697474
lymph2 / 4427045
lymph node4 / 9161043
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve3 / 15768190
ovary9 / 10205188
pancreas16 / 21481274
parathyroid5 / 20539243
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate3 / 18934515
salivary gland0 / 201550 
skin34 / 210574161
spleen2 / 5395237
stomach2 / 9661920
testis2 / 3304426
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219143_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.7
Adipocyte4.8
AdrenalCortex5.1
Adrenalgland4.35
Amygdala4.95
Appendix4.9
AtrioventricularNode3.65
BDCA4+_DentriticCells21.55
Bonemarrow4.65
BronchialEpithelialCells4.7
CD105+_Endothelial4.75
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5
CD33+_Myeloid5.9
CD34+5.95
CD4+_Tcells5
CD56+_NKCells5.45
CD71+_EarlyErythroid4.45
CD8+_Tcells4.45
CardiacMyocytes6.65
Caudatenucleus4.2
Cerebellum3.85
CerebellumPeduncles5.45
CiliaryGanglion3.4
CingulateCortex4.9
Colorectaladenocarcinoma4.75
DorsalRootGanglion3.65
FetalThyroid4.6
Fetalbrain4.65
Fetalliver4.1
Fetallung3.8
GlobusPallidus3.55
Heart7.75
Hypothalamus7.3
Kidney3.95
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.15
Leukemialymphoblastic(MOLT-4)3.75
Liver6.55
Lung22.45
Lymphnode4.05
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)6.75
MedullaOblongata4.3
OccipitalLobe4.25
OlfactoryBulb3.75
Ovary3.2
Pancreas4
PancreaticIslet5.05
ParietalLobe5.05
Pituitary5.5
Placenta4.85
Pons4.55
PrefrontalCortex5.85
Prostate5.45
Salivarygland3.85
SkeletalMuscle5.6
Skin3.7
SmoothMuscle5.35
Spinalcord6.95
SubthalamicNucleus4.35
SuperiorCervicalGanglion5.45
TemporalLobe4.4
Testis4.1
TestisGermCell4.45
TestisIntersitial3.95
TestisLeydigCell4.65
TestisSeminiferousTubule4.05
Thalamus4.9
Thymus3.65
Thyroid12.55
Tongue4.7
Tonsil4.65
Trachea3.95
TrigeminalGanglion4.85
Uterus3.8
UterusCorpus4.3
WholeBlood5.1
Wholebrain5.5
colon4.75
pineal_day6.74
pineal_night7.2
retina7.375
small_intestine4.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8135_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.92 ± 1.09
Basal Forebrain1.63 ± 0.31
Basal Part of Pons1.22 ± 0.42
Cerebellar Cortex1.34 ± 0.73
Cerebellar Nuclei1.7 ± 0.75
Claustrum2.36 ± 0.8
Epithalamus1.23 ± 0.7
Frontal Lobe1.37 ± 0.7
Globus Pallidus1.94 ± 0.39
Hypothalamus1.72 ± 0.79
Insula1.37 ± 0.6
Limbic Lobe1.47 ± 0.65
Mesencephalon1.62 ± 0.7
Myelencephalon1.52 ± 0.65
Occipital Lobe1.52 ± 0.63
Parietal Lobe1.54 ± 0.69
Pontine Tegmentum1.54 ± 0.73
Striatum1.55 ± 0.55
Subthalamus1.61 ± 0.63
Temporal Lobe1.45 ± 0.67
Thalamus1.47 ± 0.61
White Matter1.75 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rpp25CBCerebellum15.74
18.84
Rpp25CTXCerebral cortex49.63
41.39
Rpp25HIPHippocampal region28.42
31.4
Rpp25HPFHippocampal formation34.56
33.87
Rpp25HYHypothalamus7.45
7.52
Rpp25LSXLateral septal complex3.5
2.49
Rpp25MBMidbrain26.47
26.25
Rpp25MYMedulla15.74
15.2
Rpp25OLFOlfactory bulb35.27
29.25
Rpp25PPons13.79
13.55
Rpp25PALPallidum9.94
7.76
Rpp25RHPRetrohippocampal region44.93
37.79
Rpp25sAMYStriatum-like amygdalar nuclei14.76
10.77
Rpp25STRStriatum10.61
8.5
Rpp25STRdStriatum dorsal region10.24
8.25
Rpp25STRvStriatum ventral region14.36
11.91
Rpp25THThalamus12.27
11.97
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00011949 33 7 39 VRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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