Annotation Detail for PPL
Basic Information Top
| Gene Symbol: | PPL ( KIAA0568,MGC134872 ) |
|---|---|
| Gene Full Name: | periplakin |
| Band: | 16p13.3 |
| Quick Links | Entrez ID:5493; OMIM: 602871; Uniprot ID:PEPL_HUMAN; ENSEMBL ID: ENSG00000118898; HGNC ID: 9273 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.192233
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 5 / 564012 | 8 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 90 / 1939121 | 46 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 |  |
| breast (mammary gland) tumor | 9 / 94178 | 95 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 2 / 114246 | 17 | |
| esophageal tumor | 2 / 17290 | 115 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 4 / 263845 | 15 | |
| glioma | 1 / 106883 | 9 | |
| head and neck tumor | 21 / 136302 | 154 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 11 / 103127 | 106 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 7 / 97250 | 71 | |
| normal | 71 / 3360307 | 21 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 5 / 104616 | 47 | |
| primitive neuroectodermal tumor of the CNS | 1 / 125680 | 7 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 2 / 46356 | 43 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 3 / 90257 | 33 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 3 / 29757 | 100 | |
| blood | 0 / 123478 | 0 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 14 / 1100989 | 12 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 4 / 215722 | 18 | |
| esophagus | 2 / 20209 | 98 | |
| eye | 15 / 211054 | 71 | |
| heart | 5 / 89626 | 55 | |
| intestine | 5 / 234472 | 21 | |
| kidney | 1 / 211777 | 4 | |
| larynx | 5 / 24145 | 207 |  |
| liver | 2 / 207743 | 9 | |
| lung | 23 / 336974 | 68 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 22 / 153271 | 143 | |
| mouth | 7 / 67052 | 104 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 10 / 214812 | 46 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 4 / 41328 | 96 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 6 / 189345 | 31 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 9 / 210574 | 42 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 3 / 96619 | 31 | |
| testis | 4 / 330442 | 12 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 6 / 47473 | 126 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 3 / 52413 | 57 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 5 / 232878 | 21 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203407_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.4 | |
| Adipocyte | 104.25 | |
| AdrenalCortex | 4.75 | |
| Adrenalgland | 3.8 | |
| Amygdala | 23.5 | |
| Appendix | 5 | |
| AtrioventricularNode | 3.55 | |
| BDCA4+_DentriticCells | 4.9 | |
| Bonemarrow | 4.45 | |
| BronchialEpithelialCells | 250.15 | |
| CD105+_Endothelial | 4.25 | |
| CD14+_Monocytes | 4.55 | |
| CD19+_BCells(neg._sel.) | 4.7 | |
| CD33+_Myeloid | 5.65 | |
| CD34+ | 5.55 | |
| CD4+_Tcells | 4.35 | |
| CD56+_NKCells | 5.25 | |
| CD71+_EarlyErythroid | 4.1 | |
| CD8+_Tcells | 3.85 | |
| CardiacMyocytes | 5.65 | |
| Caudatenucleus | 4.15 | |
| Cerebellum | 3.75 | |
| CerebellumPeduncles | 5.2 | |
| CiliaryGanglion | 3.45 | |
| CingulateCortex | 4.65 | |
| Colorectaladenocarcinoma | 168.05 | |
| DorsalRootGanglion | 3.55 | |
| FetalThyroid | 62.5 | |
| Fetalbrain | 4.55 | |
| Fetalliver | 4.05 | |
| Fetallung | 26.1 | |
| GlobusPallidus | 3.5 | |
| Heart | 5.65 | |
| Hypothalamus | 5.05 | |
| Kidney | 13.95 | |
| Leukemia_chronicMyelogenousK-562 | 4.1 | |
| Leukemia_promyelocytic-HL-60 | 3.95 | |
| Leukemialymphoblastic(MOLT-4) | 3.7 | |
| Liver | 6.95 | |
| Lung | 325.15 | |
| Lymphnode | 3.95 | |
| Lymphoma_burkitts(Daudi) | 5.6 | |
| Lymphoma_burkitts(Raji) | 6.2 | |
| MedullaOblongata | 4.9 | |
| OccipitalLobe | 4.2 | |
| OlfactoryBulb | 3.45 | |
| Ovary | 3.15 | |
| Pancreas | 10.1 | |
| PancreaticIslet | 56.4 | |
| ParietalLobe | 5.1 | |
| Pituitary | 28.55 | |
| Placenta | 86.6 | |
| Pons | 6.45 | |
| PrefrontalCortex | 11.9 | |
| Prostate | 118.15 | |
| Salivarygland | 46 | |
| SkeletalMuscle | 5.55 | |
| Skin | 199.95 | |
| SmoothMuscle | 5.15 | |
| Spinalcord | 4.85 | |
| SubthalamicNucleus | 4.1 | |
| SuperiorCervicalGanglion | 6.2 | |
| TemporalLobe | 4.25 | |
| Testis | 4.05 | |
| TestisGermCell | 3.95 | |
| TestisIntersitial | 3.75 | |
| TestisLeydigCell | 4.4 | |
| TestisSeminiferousTubule | 3.95 | |
| Thalamus | 4.6 | |
| Thymus | 6.25 | |
| Thyroid | 101.6 | |
| Tongue | 1616.2 |  |
| Tonsil | 362.5 | |
| Trachea | 129 | |
| TrigeminalGanglion | 4.6 | |
| Uterus | 8.65 | |
| UterusCorpus | 4.4 | |
| WholeBlood | 4.85 | |
| Wholebrain | 16.3 | |
| colon | 4.95 | |
| pineal_day | 12.92 | |
| pineal_night | 21.24 | |
| retina | 8.6 | |
| small_intestine | 4.55 | |
- Probe name: CUST_1725_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.42 ± 0.76 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.69 ± 0.22 | |
| Basal Part of Pons | 3.16 ± 0.67 | |
| Cerebellar Cortex | 2.95 ± 0.84 | |
| Cerebellar Nuclei | 3.37 ± 0.82 | |
| Claustrum | 3.43 ± 0.71 | |
| Epithalamus | 2.98 ± 0.63 | |
| Frontal Lobe | 2.92 ± 0.76 | |
| Globus Pallidus | 2.48 ± 0.55 | |
| Hypothalamus | 2.8 ± 0.57 | |
| Insula | 3.24 ± 0.67 | |
| Limbic Lobe | 3.34 ± 1.02 | |
| Mesencephalon | 3.18 ± 0.86 | |
| Myelencephalon | 3.04 ± 0.67 | |
| Occipital Lobe | 4.09 ± 0.69 | |
| Parietal Lobe | 3.35 ± 0.75 | |
| Pontine Tegmentum | 3.11 ± 0.88 | |
| Striatum | 2.21 ± 0.76 | |
| Subthalamus | 3.16 ± 0.76 | |
| Temporal Lobe | 3.21 ± 0.76 | |
| Thalamus | 2.88 ± 0.72 | |
| White Matter | 2.65 ± 0.78 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Ppl | CB | Cerebellum | 15.01 | |
| 17.45 | | |||
| Ppl | CTX | Cerebral cortex | 15.55 | |
| 10.49 | | |||
| Ppl | HIP | Hippocampal region | 9.51 | |
| 9.06 | | |||
| Ppl | HPF | Hippocampal formation | 12.11 | |
| 10.14 | | |||
| Ppl | HY | Hypothalamus | 10.93 | |
| 7.97 | | |||
| Ppl | LSX | Lateral septal complex | 6.34 | |
| 3.97 | | |||
| Ppl | MB | Midbrain | 15.24 | |
| 13.12 | | |||
| Ppl | MY | Medulla | 25.7 | |
| 28.96 | | |||
| Ppl | OLF | Olfactory bulb | 17.38 | |
| 12.19 | | |||
| Ppl | P | Pons | 24.24 | |
| 27.46 | | |||
| Ppl | PAL | Pallidum | 12.85 | |
| 11.69 | | |||
| Ppl | RHP | Retrohippocampal region | 16.18 | |
| 11.56 | | |||
| Ppl | sAMY | Striatum-like amygdalar nuclei | 2.2 | |
| 1.81 | | |||
| Ppl | STR | Striatum | 7.81 | |
| 5.49 | | |||
| Ppl | STRd | Striatum dorsal region | 7.15 | |
| 5.33 | | |||
| Ppl | STRv | Striatum ventral region | 13.67 | |
| 8.21 | | |||
| Ppl | TH | Thalamus | 13.3 | |
| 10.81 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00009711 | 13 | 222 | 234 | CTNELYWLDQQAK | Peptide Atlas |
| PEPL_HUMAN_1426 | 12 | 1426 | 1437 | LAALEQEEAEAR | PRIDE |
| PEPL_HUMAN_1573 | 8 | 1573 | 1580 | QNLQLETR | PRIDE |