AutismKB 2.0

Annotation Detail for COMMD4


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Basic Information Top
Gene Symbol:COMMD4 ( FLJ20452 )
Gene Full Name: COMM domain containing 4
Band: 15q24.2
Quick LinksEntrez ID:54939; OMIM: NA; Uniprot ID:COMD4_HUMAN; ENSEMBL ID: ENSG00000140365; HGNC ID: 26027
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus26 / 56401246
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult123 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor5 / 34366145
chondrosarcoma6 / 8282372
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor17 / 119369142
germ cell tumor11 / 26384541
glioma16 / 106883149
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia7 / 9584273
liver tumor3 / 9635931
lung tumor7 / 10312767
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal177 / 336030752
ovarian tumor7 / 7668291
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer1 / 1026809
retinoblastoma5 / 46356107
skin tumor19 / 124949152
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites3 / 4001574
bladder2 / 2975767
blood7 / 12347856
bone0 / 716550 
bone marrow3 / 4880161
brain59 / 110098953
cervix7 / 48171145
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye23 / 211054108
heart3 / 8962633
intestine14 / 23447259
kidney9 / 21177742
larynx1 / 2414541
liver6 / 20774328
lung25 / 33697474
lymph1 / 4427022
lymph node8 / 9161087
mammary gland11 / 15327171
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary8 / 10205178
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta14 / 28082549
prostate9 / 18934547
salivary gland4 / 20155198
skin25 / 210574118
spleen3 / 5395255
stomach11 / 96619113
testis29 / 33044287
thymus3 / 8113136
thyroid3 / 4747363
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord1 / 1368073
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209132_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts371.8
Adipocyte71.35
AdrenalCortex77.85
Adrenalgland131.15
Amygdala62.5
Appendix53.95
AtrioventricularNode34.1
BDCA4+_DentriticCells156.3
Bonemarrow71.25
BronchialEpithelialCells121
CD105+_Endothelial223.6
CD14+_Monocytes56.25
CD19+_BCells(neg._sel.)43.75
CD33+_Myeloid35.5
CD34+113.3
CD4+_Tcells61.45
CD56+_NKCells115.7
CD71+_EarlyErythroid230.55
CD8+_Tcells59.45
CardiacMyocytes216.65
Caudatenucleus53.15
Cerebellum59.45
CerebellumPeduncles84.55
CiliaryGanglion21
CingulateCortex58.4
Colorectaladenocarcinoma100.05
DorsalRootGanglion23.1
FetalThyroid67.05
Fetalbrain60.3
Fetalliver50.65
Fetallung57.15
GlobusPallidus34.4
Heart314.15
Hypothalamus92.05
Kidney71.6
Leukemia_chronicMyelogenousK-56296.7
Leukemia_promyelocytic-HL-6090.65
Leukemialymphoblastic(MOLT-4)110.7
Liver128.7
Lung138.7
Lymphnode75.1
Lymphoma_burkitts(Daudi)149.65
Lymphoma_burkitts(Raji)106.1
MedullaOblongata50.9
OccipitalLobe57.55
OlfactoryBulb42.65
Ovary52.6
Pancreas45.95
PancreaticIslet73.55
ParietalLobe70.15
Pituitary78.55
Placenta70.05
Pons66.65
PrefrontalCortex76.9
Prostate134.55
Salivarygland42.35
SkeletalMuscle74.7
Skin27.05
SmoothMuscle152
Spinalcord62.6
SubthalamicNucleus45.05
SuperiorCervicalGanglion55.1
TemporalLobe39.35
Testis179.1
TestisGermCell74.45
TestisIntersitial118.35
TestisLeydigCell106.25
TestisSeminiferousTubule106.5
Thalamus65.35
Thymus206.5
Thyroid114.6
Tongue64.6
Tonsil83.1
Trachea52.3
TrigeminalGanglion41.3
Uterus60.1
UterusCorpus88.1
WholeBlood66
Wholebrain95.85
colon78.05
pineal_day73.36
pineal_night73.5
retina67.775
small_intestine70.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P117767
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.2 ± 0.53
Basal Forebrain5.12 ± 0.71
Basal Part of Pons5.75 ± 0.29
Cerebellar Cortex5.32 ± 0.56
Cerebellar Nuclei5.12 ± 0.62
Claustrum4.63 ± 0.91
Epithalamus5.63 ± 0.4
Frontal Lobe5.51 ± 0.48
Globus Pallidus5.83 ± 0.33
Hypothalamus5.77 ± 0.55
Insula5.49 ± 0.42
Limbic Lobe5.1 ± 0.67
Mesencephalon5.36 ± 0.55
Myelencephalon5.34 ± 0.56
Occipital Lobe4.84 ± 0.53
Parietal Lobe5.32 ± 0.56
Pontine Tegmentum5.31 ± 0.59
Striatum5.22 ± 0.43
Subthalamus5.37 ± 0.46
Temporal Lobe5.46 ± 0.47
Thalamus5.37 ± 0.5
White Matter5.71 ± 0.68
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Commd4CBCerebellum8.09
7.87
Commd4CTXCerebral cortex54.02
37.99
Commd4HIPHippocampal region34.71
38.55
Commd4HPFHippocampal formation39.06
37.18
Commd4HYHypothalamus13.33
9.45
Commd4LSXLateral septal complex19.95
13.17
Commd4MBMidbrain12.57
10.34
Commd4MYMedulla18.2
18.35
Commd4OLFOlfactory bulb43.42
33.34
Commd4PPons14.38
14.94
Commd4PALPallidum12.83
9.88
Commd4RHPRetrohippocampal region52.19
38.48
Commd4sAMYStriatum-like amygdalar nuclei17.37
11.67
Commd4STRStriatum19.35
12.77
Commd4STRdStriatum dorsal region20.02
13.3
Commd4STRvStriatum ventral region18.17
11.52
Commd4THThalamus13.93
10
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
COMD4_HUMAN_137 21 137 157 VDYTLSSSLLQSVEEPMVHLR PRIDE
COMD4_HUMAN_138 21 138 158 VDYTLSSSLLQSVEEPMVHLR PRIDE
COMD4_HUMAN_66 15 66 80 ATVAVLSFILSSAAK PRIDE
PAp00095825 20 5 24 FCGDLDCPDWVLAEISTLAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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