AutismKB 2.0

Annotation Detail for PPM1A


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Basic Information Top
Gene Symbol:PPM1A ( FLJ42306,MGC9201,PP2C-ALPHA,PP2CA,PP2Calpha )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1A
Band: 14q23.1
Quick LinksEntrez ID:5494; OMIM: 606108; Uniprot ID:PPM1A_HUMAN; ENSEMBL ID: ENSG00000100614; HGNC ID: 9275
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus31 / 56401254
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor6 / 26384522
glioma3 / 10688328
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia5 / 9725051
normal189 / 336030756
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites2 / 4001549
bladder3 / 29757100
blood4 / 12347832
bone6 / 7165583
bone marrow1 / 4880120
brain56 / 110098950
cervix1 / 4817120
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye12 / 21105456
heart2 / 8962622
intestine8 / 23447234
kidney13 / 21177761
larynx1 / 2414541
liver10 / 20774348
lung12 / 33697435
lymph5 / 44270112
lymph node7 / 9161076
mammary gland12 / 15327178
mouth3 / 6705244
muscle7 / 10771564
nerve3 / 15768190
ovary1 / 1020519
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta9 / 28082532
prostate9 / 18934547
salivary gland0 / 201550 
skin11 / 21057452
spleen0 / 539520 
stomach8 / 9661982
testis24 / 33044272
thymus9 / 81131110
thyroid3 / 4747363
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus16 / 23287868
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203966_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts523.55
Adipocyte97.75
AdrenalCortex35.9
Adrenalgland54.5
Amygdala66.55
Appendix44.85
AtrioventricularNode17.15
BDCA4+_DentriticCells227.8
Bonemarrow317.7
BronchialEpithelialCells83.65
CD105+_Endothelial117.25
CD14+_Monocytes127.8
CD19+_BCells(neg._sel.)183.35
CD33+_Myeloid141.05
CD34+141.25
CD4+_Tcells160.9
CD56+_NKCells345.9
CD71+_EarlyErythroid658.1
CD8+_Tcells123.75
CardiacMyocytes41.85
Caudatenucleus43.4
Cerebellum64.6
CerebellumPeduncles69.9
CiliaryGanglion41.2
CingulateCortex73.85
Colorectaladenocarcinoma30.5
DorsalRootGanglion43.7
FetalThyroid64.4
Fetalbrain83.2
Fetalliver120
Fetallung117.75
GlobusPallidus67.65
Heart40.8
Hypothalamus110.85
Kidney121.6
Leukemia_chronicMyelogenousK-56218.4
Leukemia_promyelocytic-HL-60522.85
Leukemialymphoblastic(MOLT-4)134.6
Liver33.2
Lung42.6
Lymphnode71.85
Lymphoma_burkitts(Daudi)210.7
Lymphoma_burkitts(Raji)277.65
MedullaOblongata91.15
OccipitalLobe94.45
OlfactoryBulb31.8
Ovary35
Pancreas45.6
PancreaticIslet91.1
ParietalLobe82.55
Pituitary193.45
Placenta191.3
Pons87.45
PrefrontalCortex108.25
Prostate137.05
Salivarygland124.85
SkeletalMuscle59.75
Skin30.55
SmoothMuscle77.95
Spinalcord76.25
SubthalamicNucleus106.05
SuperiorCervicalGanglion79.7
TemporalLobe91.7
Testis183.8
TestisGermCell168.25
TestisIntersitial298.8
TestisLeydigCell220.5
TestisSeminiferousTubule176.3
Thalamus111.7
Thymus101.9
Thyroid55.95
Tongue76.55
Tonsil87
Trachea102.45
TrigeminalGanglion50.05
Uterus72.7
UterusCorpus44.2
WholeBlood511.6
Wholebrain88.2
colon198.55
pineal_day83.5
pineal_night95.8
retina193.425
small_intestine164.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P688133
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.57 ± 0.7
Basal Forebrain7.2 ± 0.15
Basal Part of Pons7.13 ± 0.27
Cerebellar Cortex7.47 ± 0.18
Cerebellar Nuclei7.28 ± 0.31
Claustrum6.85 ± 0.67
Epithalamus6.69 ± 0.62
Frontal Lobe7.22 ± 0.38
Globus Pallidus6.55 ± 0.22
Hypothalamus7.36 ± 0.29
Insula7.1 ± 0.34
Limbic Lobe6.63 ± 0.54
Mesencephalon7.25 ± 0.38
Myelencephalon7.03 ± 0.47
Occipital Lobe6.77 ± 0.53
Parietal Lobe7.12 ± 0.43
Pontine Tegmentum7.09 ± 0.42
Striatum6.27 ± 0.44
Subthalamus7.83 ± 0.24
Temporal Lobe7.13 ± 0.33
Thalamus7.16 ± 0.38
White Matter6.88 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppm1aCBCerebellum38.14
25.07
Ppm1aCTXCerebral cortex77.5
44.68
Ppm1aHIPHippocampal region71.15
40.02
Ppm1aHPFHippocampal formation75.65
43.11
Ppm1aHYHypothalamus41.2
21.42
Ppm1aLSXLateral septal complex20.39
8.8
Ppm1aMBMidbrain55.69
33.28
Ppm1aMYMedulla60.36
48.59
Ppm1aOLFOlfactory bulb71.06
38.36
Ppm1aPPons62.39
47.11
Ppm1aPALPallidum37.72
24.5
Ppm1aRHPRetrohippocampal region74.79
45.98
Ppm1asAMYStriatum-like amygdalar nuclei37.34
17.88
Ppm1aSTRStriatum22.29
10.01
Ppm1aSTRdStriatum dorsal region18.63
8.4
Ppm1aSTRvStriatum ventral region28.19
11.49
Ppm1aTHThalamus42.13
21.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00028731 17 70 86 YCCEHLLDHITNNQDFK Peptide Atlas
PPM1A_HUMAN_174 12 174 185 IQNAGGSVMIQR PRIDE
PPM1A_HUMAN_323 13 323 335 QGEGVPDLVHVMR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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