AutismKB 2.0

Annotation Detail for PPM1G


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Basic Information Top
Gene Symbol:PPM1G ( MGC1675,MGC2870,PP2CG,PP2CGAMMA,PPP2CG )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1G
Band: 2p23.3
Quick LinksEntrez ID:5496; OMIM: 605119; Uniprot ID:PPM1G_HUMAN; ENSEMBL ID: ENSG00000115241; HGNC ID: 9278
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst8 / 62319128
fetus87 / 564012154
neonate20 / 31097643
infant6 / 23620254
juvenile49 / 55556881
adult359 / 1939121185
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor37 / 94178392
cervical tumor14 / 34366407
chondrosarcoma7 / 8282384
colorectal tumor41 / 114246358
esophageal tumor10 / 17290578
gastrointestinal tumor30 / 119369251
germ cell tumor136 / 263845515
glioma36 / 106883336
head and neck tumor15 / 136302110
kidney tumor18 / 68959261
leukemia22 / 95842229
liver tumor56 / 96359581
lung tumor35 / 103127339
lymphoma13 / 71755181
non-neoplasia13 / 97250133
normal526 / 3360307156
ovarian tumor21 / 76682273
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS82 / 125680652
prostate cancer8 / 10268077
retinoblastoma26 / 46356560
skin tumor53 / 124949424
soft tissue/muscle tissue tumor39 / 125191311
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland5 / 33197150
ascites21 / 40015524
bladder2 / 2975767
blood32 / 123478259
bone8 / 71655111
bone marrow19 / 48801389
brain232 / 1100989210
cervix14 / 48171290
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus11 / 20209544
eye51 / 211054241
heart9 / 89626100
intestine63 / 234472268
kidney54 / 211777254
larynx4 / 24145165
liver72 / 207743346
lung63 / 336974186
lymph8 / 44270180
lymph node6 / 9161065
mammary gland44 / 153271287
mouth5 / 6705274
muscle12 / 107715111
nerve2 / 15768126
ovary30 / 102051293
pancreas21 / 21481297
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta50 / 280825178
prostate21 / 189345110
salivary gland1 / 2015549
skin81 / 210574384
spleen12 / 53952222
stomach15 / 96619155
testis150 / 330442453
thymus28 / 81131345
thyroid7 / 47473147
tonsil7 / 16999411
trachea10 / 52413190
umbilical cord6 / 13680438
uterus53 / 232878227
vascular19 / 51780366
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200913_at
Cell line Expression level Expression bar
721_B_lymphoblasts212.15
Adipocyte36.75
AdrenalCortex31.75
Adrenalgland33
Amygdala30.15
Appendix23.3
AtrioventricularNode22.15
BDCA4+_DentriticCells99.75
Bonemarrow41.35
BronchialEpithelialCells82.15
CD105+_Endothelial49.85
CD14+_Monocytes54.1
CD19+_BCells(neg._sel.)32.25
CD33+_Myeloid48.2
CD34+104.1
CD4+_Tcells44.5
CD56+_NKCells90.8
CD71+_EarlyErythroid106.1
CD8+_Tcells42.85
CardiacMyocytes45.85
Caudatenucleus33.2
Cerebellum29.95
CerebellumPeduncles42
CiliaryGanglion16
CingulateCortex37.65
Colorectaladenocarcinoma148.1
DorsalRootGanglion16.05
FetalThyroid34.8
Fetalbrain50.1
Fetalliver31.95
Fetallung31.45
GlobusPallidus22.2
Heart40.6
Hypothalamus40.5
Kidney29.8
Leukemia_chronicMyelogenousK-562145.75
Leukemia_promyelocytic-HL-60116.9
Leukemialymphoblastic(MOLT-4)103.4
Liver48.95
Lung48.95
Lymphnode32.05
Lymphoma_burkitts(Daudi)239.55
Lymphoma_burkitts(Raji)81.05
MedullaOblongata23.8
OccipitalLobe27.3
OlfactoryBulb28.75
Ovary13.8
Pancreas36.2
PancreaticIslet42.5
ParietalLobe28.75
Pituitary41.8
Placenta42.4
Pons17.25
PrefrontalCortex38.9
Prostate41.8
Salivarygland21.2
SkeletalMuscle29.9
Skin19.45
SmoothMuscle42.45
Spinalcord39.7
SubthalamicNucleus24.35
SuperiorCervicalGanglion19
TemporalLobe20.9
Testis508.3
TestisGermCell666.35
TestisIntersitial390.4
TestisLeydigCell221.6
TestisSeminiferousTubule293.4
Thalamus32.8
Thymus61.2
Thyroid47.15
Tongue24.35
Tonsil42.4
Trachea31.1
TrigeminalGanglion14.8
Uterus28.55
UterusCorpus21.3
WholeBlood47.5
Wholebrain33
colon37.35
pineal_day46.42
pineal_night37.94
retina44.925
small_intestine35.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9055_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.16 ± 0.51
Basal Forebrain5.18 ± 0.24
Basal Part of Pons5.4 ± 0.52
Cerebellar Cortex5.39 ± 0.47
Cerebellar Nuclei5.08 ± 0.52
Claustrum5.47 ± 0.5
Epithalamus5.41 ± 0.62
Frontal Lobe5.29 ± 0.41
Globus Pallidus4.84 ± 0.3
Hypothalamus5.18 ± 0.4
Insula5.26 ± 0.36
Limbic Lobe5.22 ± 0.47
Mesencephalon5.16 ± 0.38
Myelencephalon5.19 ± 0.46
Occipital Lobe5 ± 0.37
Parietal Lobe5.23 ± 0.44
Pontine Tegmentum5.13 ± 0.49
Striatum4.97 ± 0.35
Subthalamus5.31 ± 0.35
Temporal Lobe5.35 ± 0.4
Thalamus5.24 ± 0.38
White Matter5.27 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppm1gCBCerebellum25.49
30.06
Ppm1gCTXCerebral cortex61.24
42.22
Ppm1gHIPHippocampal region60.91
55.72
Ppm1gHPFHippocampal formation63.02
51.21
Ppm1gHYHypothalamus45.95
29.54
Ppm1gLSXLateral septal complex37.37
21.8
Ppm1gMBMidbrain34.34
25.81
Ppm1gMYMedulla28.82
34.24
Ppm1gOLFOlfactory bulb79.5
50.75
Ppm1gPPons31.88
33.21
Ppm1gPALPallidum30.52
23.09
Ppm1gRHPRetrohippocampal region67.02
44.98
Ppm1gsAMYStriatum-like amygdalar nuclei49.97
29.26
Ppm1gSTRStriatum21.61
12.18
Ppm1gSTRdStriatum dorsal region11.25
6.19
Ppm1gSTRvStriatum ventral region38.28
19.7
Ppm1gTHThalamus39.6
27.98
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003131 30 221 250 GTEAGQVGEPGIPTGEAGPSCSSASDKLPR Peptide Atlas
PPM1G_HUMAN_139 21 139 159 NEEAALLHEEATMTIEELLTR PRIDE
PPM1G_HUMAN_22 14 22 35 LPLPYGFSAMQGWR PRIDE
PPM1G_HUMAN_340 11 340 350 QLIVANAGDSR PRIDE
PPM1G_HUMAN_410 16 410 425 NLPPEEQMISALPDIK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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