AutismKB 2.0

Annotation Detail for TMEM70


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Basic Information Top
Gene Symbol:TMEM70 ( FLJ20533 )
Gene Full Name: transmembrane protein 70
Band: 8q21.11
Quick LinksEntrez ID:54968; OMIM: 612418; Uniprot ID:TMM70_HUMAN; ENSEMBL ID: ENSG00000175606; HGNC ID: 26050
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus32 / 56401256
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult64 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor3 / 26384511
glioma10 / 10688393
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal106 / 336030731
ovarian tumor9 / 76682117
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain38 / 110098934
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye4 / 21105418
heart3 / 8962633
intestine6 / 23447225
kidney12 / 21177756
larynx0 / 241450 
liver2 / 2077439
lung33 / 33697497
lymph1 / 4427022
lymph node15 / 91610163
mammary gland5 / 15327132
mouth1 / 6705214
muscle5 / 10771546
nerve1 / 1576863
ovary9 / 10205188
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate8 / 18934542
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis8 / 33044224
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219449_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts692.7
Adipocyte135.4
AdrenalCortex39.1
Adrenalgland160.6
Amygdala431.4
Appendix61.25
AtrioventricularNode29.2
BDCA4+_DentriticCells427.15
Bonemarrow64.45
BronchialEpithelialCells284.9
CD105+_Endothelial469.05
CD14+_Monocytes279.4
CD19+_BCells(neg._sel.)144.7
CD33+_Myeloid136.05
CD34+274.2
CD4+_Tcells67.15
CD56+_NKCells209.9
CD71+_EarlyErythroid122.2
CD8+_Tcells69.2
CardiacMyocytes125
Caudatenucleus59.15
Cerebellum115.1
CerebellumPeduncles87.45
CiliaryGanglion55.7
CingulateCortex102.25
Colorectaladenocarcinoma75
DorsalRootGanglion35.1
FetalThyroid53.15
Fetalbrain95.55
Fetalliver83.4
Fetallung86.8
GlobusPallidus33.9
Heart71.2
Hypothalamus149.2
Kidney63.2
Leukemia_chronicMyelogenousK-562470.3
Leukemia_promyelocytic-HL-60210.8
Leukemialymphoblastic(MOLT-4)181.85
Liver136.95
Lung179.3
Lymphnode95.8
Lymphoma_burkitts(Daudi)203.5
Lymphoma_burkitts(Raji)232.6
MedullaOblongata78.85
OccipitalLobe146.25
OlfactoryBulb66.2
Ovary14
Pancreas64.9
PancreaticIslet179.65
ParietalLobe78.9
Pituitary80.1
Placenta106.15
Pons52.15
PrefrontalCortex188.05
Prostate240.85
Salivarygland84.4
SkeletalMuscle600.85
Skin40.1
SmoothMuscle112.2
Spinalcord102.4
SubthalamicNucleus61.85
SuperiorCervicalGanglion70.85
TemporalLobe92.6
Testis213.8
TestisGermCell162.15
TestisIntersitial87.05
TestisLeydigCell84.7
TestisSeminiferousTubule74.25
Thalamus69.85
Thymus131.15
Thyroid195.25
Tongue59.1
Tonsil98.35
Trachea84.95
TrigeminalGanglion41.55
Uterus116.55
UterusCorpus36.65
WholeBlood250.4
Wholebrain617.7
colon377.1
pineal_day153.28
pineal_night217.14
retina128.125
small_intestine383.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P253963
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.76 ± 0.57
Basal Forebrain8.59 ± 0.32
Basal Part of Pons9.62 ± 0.19
Cerebellar Cortex9.35 ± 0.21
Cerebellar Nuclei9.94 ± 0.4
Claustrum9.02 ± 0.42
Epithalamus8.71 ± 0.19
Frontal Lobe9.54 ± 0.38
Globus Pallidus8.21 ± 0.39
Hypothalamus9.34 ± 0.29
Insula9.46 ± 0.39
Limbic Lobe9.24 ± 0.59
Mesencephalon8.95 ± 0.59
Myelencephalon9.05 ± 0.62
Occipital Lobe8.63 ± 0.52
Parietal Lobe9.18 ± 0.52
Pontine Tegmentum9.23 ± 0.46
Striatum8.32 ± 0.52
Subthalamus10.34 ± 0.28
Temporal Lobe9.33 ± 0.38
Thalamus8.93 ± 0.32
White Matter8.07 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem70CBCerebellum7.52
13.35
Tmem70CTXCerebral cortex1.58
1.28
Tmem70HIPHippocampal region5.32
5.56
Tmem70HPFHippocampal formation3.31
3.16
Tmem70HYHypothalamus0.15
0.21
Tmem70LSXLateral septal complex0
0
Tmem70MBMidbrain0.63
0.72
Tmem70MYMedulla0.2
0.25
Tmem70OLFOlfactory bulb0.47
0.73
Tmem70PPons0.64
1.02
Tmem70PALPallidum0.41
0.49
Tmem70RHPRetrohippocampal region0.49
0.34
Tmem70sAMYStriatum-like amygdalar nuclei0.05
0.21
Tmem70STRStriatum0.18
0.22
Tmem70STRdStriatum dorsal region0.21
0.14
Tmem70STRvStriatum ventral region0.09
0.17
Tmem70THThalamus3.25
3.03
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000454 21 181 201 AITYNAMLAETSTVFHQNDVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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