AutismKB 2.0

Annotation Detail for PPP1CA


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Basic Information Top
Gene Symbol:PPP1CA ( MGC15877,MGC1674,PP-1A,PP1alpha,PPP1A )
Gene Full Name: protein phosphatase 1, catalytic subunit, alpha isozyme
Band: 11q13
Quick LinksEntrez ID:5499; OMIM: 176875; Uniprot ID:PP1A_HUMAN; ENSEMBL ID: ENSG00000172531; HGNC ID: 9281
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body15 / 70761211
blastocyst18 / 62319288
fetus37 / 56401265
neonate3 / 3109796
infant0 / 236200 
juvenile15 / 55556269
adult326 / 1939121168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor14 / 94178148
cervical tumor21 / 34366611
chondrosarcoma10 / 82823120
colorectal tumor36 / 114246315
esophageal tumor3 / 17290173
gastrointestinal tumor36 / 119369301
germ cell tumor55 / 263845208
glioma27 / 106883252
head and neck tumor12 / 13630288
kidney tumor19 / 68959275
leukemia30 / 95842313
liver tumor19 / 96359197
lung tumor36 / 103127349
lymphoma34 / 71755473
non-neoplasia7 / 9725071
normal372 / 3360307110
ovarian tumor19 / 76682247
pancreatic tumor38 / 104616363
primitive neuroectodermal tumor of the CNS54 / 125680429
prostate cancer28 / 102680272
retinoblastoma21 / 46356453
skin tumor58 / 124949464
soft tissue/muscle tissue tumor25 / 125191199
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites6 / 40015149
bladder3 / 29757100
blood35 / 123478283
bone13 / 71655181
bone marrow4 / 4880181
brain106 / 110098996
cervix22 / 48171456
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue44 / 215722203
esophagus3 / 20209148
eye42 / 211054199
heart8 / 8962689
intestine58 / 234472247
kidney37 / 211777174
larynx2 / 2414582
liver29 / 207743139
lung69 / 336974204
lymph26 / 44270587
lymph node14 / 91610152
mammary gland26 / 153271169
mouth2 / 6705229
muscle12 / 107715111
nerve2 / 15768126
ovary21 / 102051205
pancreas45 / 214812209
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta55 / 280825195
prostate36 / 189345190
salivary gland3 / 20155148
skin66 / 210574313
spleen3 / 5395255
stomach35 / 96619362
testis18 / 33044254
thymus7 / 8113186
thyroid7 / 47473147
tonsil20 / 169991176
trachea0 / 524130 
umbilical cord1 / 1368073
uterus39 / 232878167
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200846_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1148.95
Adipocyte116.25
AdrenalCortex82.4
Adrenalgland110.95
Amygdala112.9
Appendix37.55
AtrioventricularNode28.2
BDCA4+_DentriticCells922.25
Bonemarrow216.45
BronchialEpithelialCells363.3
CD105+_Endothelial381.7
CD14+_Monocytes993.4
CD19+_BCells(neg._sel.)790.1
CD33+_Myeloid691.45
CD34+555.3
CD4+_Tcells799.25
CD56+_NKCells1628.8
CD71+_EarlyErythroid333.65
CD8+_Tcells746.4
CardiacMyocytes335.55
Caudatenucleus102.45
Cerebellum72.1
CerebellumPeduncles101.45
CiliaryGanglion28.6
CingulateCortex74.85
Colorectaladenocarcinoma766.95
DorsalRootGanglion31.5
FetalThyroid173.9
Fetalbrain73.75
Fetalliver97.1
Fetallung148.2
GlobusPallidus33.5
Heart559.45
Hypothalamus104.15
Kidney110.25
Leukemia_chronicMyelogenousK-562158.85
Leukemia_promyelocytic-HL-60168.05
Leukemialymphoblastic(MOLT-4)397.35
Liver416.45
Lung637.05
Lymphnode173.3
Lymphoma_burkitts(Daudi)270.3
Lymphoma_burkitts(Raji)512.6
MedullaOblongata62.4
OccipitalLobe95.55
OlfactoryBulb44.35
Ovary29.75
Pancreas71.15
PancreaticIslet84.85
ParietalLobe88
Pituitary82.35
Placenta311.55
Pons67.55
PrefrontalCortex110.45
Prostate700.15
Salivarygland46
SkeletalMuscle92.65
Skin39.5
SmoothMuscle322.9
Spinalcord95
SubthalamicNucleus41
SuperiorCervicalGanglion41.45
TemporalLobe71.1
Testis90
TestisGermCell69.65
TestisIntersitial43
TestisLeydigCell50.35
TestisSeminiferousTubule68.5
Thalamus68.45
Thymus604.7
Thyroid549.7
Tongue86
Tonsil386.05
Trachea80.55
TrigeminalGanglion37.3
Uterus68.3
UterusCorpus52.1
WholeBlood856.7
Wholebrain238.55
colon519.75
pineal_day131.14
pineal_night111.74
retina122.45
small_intestine343.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P434710
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.13 ± 0.25
Basal Forebrain7.98 ± 0.15
Basal Part of Pons8.08 ± 0.18
Cerebellar Cortex7.8 ± 0.22
Cerebellar Nuclei7.99 ± 0.22
Claustrum8.26 ± 0.4
Epithalamus7.65 ± 0.24
Frontal Lobe8.05 ± 0.29
Globus Pallidus7.92 ± 0.31
Hypothalamus7.82 ± 0.17
Insula7.96 ± 0.26
Limbic Lobe8.08 ± 0.32
Mesencephalon7.91 ± 0.33
Myelencephalon8.03 ± 0.33
Occipital Lobe7.71 ± 0.29
Parietal Lobe7.92 ± 0.28
Pontine Tegmentum7.89 ± 0.27
Striatum8.34 ± 0.34
Subthalamus7.54 ± 0.15
Temporal Lobe8.04 ± 0.28
Thalamus7.94 ± 0.29
White Matter8.26 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1caCBCerebellum23.71
29.09
Ppp1caCTXCerebral cortex69.15
57.2
Ppp1caHIPHippocampal region39.85
59.55
Ppp1caHPFHippocampal formation40.62
50.52
Ppp1caHYHypothalamus9.99
7.97
Ppp1caLSXLateral septal complex18.62
14.13
Ppp1caMBMidbrain8.78
9.15
Ppp1caMYMedulla14.71
16.54
Ppp1caOLFOlfactory bulb49.22
52.49
Ppp1caPPons13.94
16.36
Ppp1caPALPallidum18.85
19.59
Ppp1caRHPRetrohippocampal region41.65
37.55
Ppp1casAMYStriatum-like amygdalar nuclei29.7
23.42
Ppp1caSTRStriatum89.03
79.54
Ppp1caSTRdStriatum dorsal region100
100
Ppp1caSTRvStriatum ventral region62.32
53.33
Ppp1caTHThalamus15.04
13.94
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000412 14 258 271 AHQVVEDGYEFFAK Peptide Atlas
PP1A_HUMAN_111 11 111 121 IKYPENFFLLR PRIDE
PP1A_HUMAN_132 10 132 141 IYGFYDECKR PRIDE
PP1A_HUMAN_132 9 132 140 IYGFYDECK PRIDE
PP1A_HUMAN_150 18 150 167 TFTDCFNCLPIAAIVDEK PRIDE
PP1A_HUMAN_168 19 168 186 IFCCHGGLSPDLQSMEQIR PRIDE
PP1A_HUMAN_168 20 168 187 IFCCHGGLSPDLQSMEQIRR PRIDE
PP1A_HUMAN_2 14 2 15 SDSEKLNLDSIIGR PRIDE
PP1A_HUMAN_234 12 234 245 FLHKHDLDLICR PRIDE
PP1A_HUMAN_246 14 246 259 AHQVVEDGYEFFAK PRIDE
PP1A_HUMAN_246 15 246 260 AHQVVEDGYEFFAKR PRIDE
PP1A_HUMAN_26 10 26 35 NVQLTENEIR PRIDE
PP1A_HUMAN_305 18 305 322 YGQFSGLNPGGRPITPPR PRIDE
PP1A_HUMAN_318 6 318 323 PITPPR PRIDE
PP1A_HUMAN_41 19 41 59 SREIFLSQPILLELEAPLK PRIDE
PP1A_HUMAN_43 17 43 59 EIFLSQPILLELEAPLK PRIDE
PP1A_HUMAN_60 14 60 73 ICGDIHGQYYDLLR PRIDE
PP1A_HUMAN_98 13 98 110 QSLETICLLLAYK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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