AutismKB 2.0

Annotation Detail for HERC6


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Basic Information Top
Gene Symbol:HERC6 ( FLJ20637 )
Gene Full Name: hect domain and RLD 6
Band: 4q22.1
Quick LinksEntrez ID:55008; OMIM: 609249; Uniprot ID:HERC6_HUMAN; ENSEMBL ID: ENSG00000138642; HGNC ID: 26072
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult41 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor4 / 34366116
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal66 / 336030719
ovarian tumor2 / 7668226
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain29 / 110098926
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye4 / 21105418
heart2 / 8962622
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta5 / 28082517
prostate6 / 18934531
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach1 / 9661910
testis4 / 33044212
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus17 / 23287872
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219352_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.7
Adipocyte5.2
AdrenalCortex5.6
Adrenalgland4.4
Amygdala5.5
Appendix8.75
AtrioventricularNode4.4
BDCA4+_DentriticCells5.85
Bonemarrow5.25
BronchialEpithelialCells5.2
CD105+_Endothelial5.4
CD14+_Monocytes5.7
CD19+_BCells(neg._sel.)5.7
CD33+_Myeloid6.85
CD34+6.8
CD4+_Tcells12.1
CD56+_NKCells11.05
CD71+_EarlyErythroid4.9
CD8+_Tcells5.35
CardiacMyocytes6.75
Caudatenucleus4.75
Cerebellum4.2
CerebellumPeduncles5.95
CiliaryGanglion6.5
CingulateCortex6.6
Colorectaladenocarcinoma5.3
DorsalRootGanglion7.8
FetalThyroid5.15
Fetalbrain5.25
Fetalliver4.55
Fetallung4.35
GlobusPallidus5.3
Heart6.8
Hypothalamus6.2
Kidney4.25
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.65
Leukemialymphoblastic(MOLT-4)4.25
Liver7
Lung5.9
Lymphnode4.85
Lymphoma_burkitts(Daudi)6.75
Lymphoma_burkitts(Raji)7.45
MedullaOblongata6.6
OccipitalLobe4.75
OlfactoryBulb7.9
Ovary10.85
Pancreas5.1
PancreaticIslet5.7
ParietalLobe5.9
Pituitary6.2
Placenta5.5
Pons6.15
PrefrontalCortex9.3
Prostate6.35
Salivarygland5.5
SkeletalMuscle6.35
Skin4.5
SmoothMuscle5.95
Spinalcord5.6
SubthalamicNucleus5
SuperiorCervicalGanglion9.25
TemporalLobe4.9
Testis4.5
TestisGermCell4.45
TestisIntersitial4.5
TestisLeydigCell5.25
TestisSeminiferousTubule4.6
Thalamus5.3
Thymus5.65
Thyroid6.5
Tongue9.4
Tonsil10.2
Trachea4.4
TrigeminalGanglion17.1
Uterus6.25
UterusCorpus5
WholeBlood5.7
Wholebrain4.5
colon5.25
pineal_day63.32
pineal_night58.06
retina6.5
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P250358
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.99 ± 1.37
Basal Forebrain2.2 ± 0.27
Basal Part of Pons2.02 ± 0.39
Cerebellar Cortex1.63 ± 0.45
Cerebellar Nuclei2.61 ± 0.84
Claustrum2.89 ± 0.91
Epithalamus2.03 ± 0.93
Frontal Lobe2.46 ± 0.77
Globus Pallidus2.18 ± 0.8
Hypothalamus2.23 ± 0.79
Insula2.59 ± 0.57
Limbic Lobe2.15 ± 0.69
Mesencephalon2.31 ± 0.76
Myelencephalon2.33 ± 0.85
Occipital Lobe2.11 ± 0.91
Parietal Lobe2.42 ± 0.85
Pontine Tegmentum2.36 ± 0.84
Striatum2.11 ± 0.89
Subthalamus2.12 ± 0.57
Temporal Lobe2.19 ± 0.83
Thalamus2.13 ± 0.67
White Matter1.54 ± 0.59
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Herc5CBCerebellum0.31
0.81
Herc5CTXCerebral cortex2.41
2.02
Herc5HIPHippocampal region0.24
0.56
Herc5HPFHippocampal formation0.28
0.63
Herc5HYHypothalamus0.15
0.14
Herc5LSXLateral septal complex0.21
0.17
Herc5MBMidbrain0.27
0.67
Herc5MYMedulla1.89
3.46
Herc5OLFOlfactory bulb0.89
1.07
Herc5PPons0.19
0.31
Herc5PALPallidum0.34
0.8
Herc5RHPRetrohippocampal region0.33
0.67
Herc5sAMYStriatum-like amygdalar nuclei0.16
0.43
Herc5STRStriatum0.23
0.29
Herc5STRdStriatum dorsal region0.17
0.26
Herc5STRvStriatum ventral region0.42
0.38
Herc5THThalamus0.26
0.43
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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