AutismKB 2.0

Annotation Detail for CCDC109B


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Basic Information Top
Gene Symbol:CCDC109B ( FLJ20647 )
Gene Full Name: coiled-coil domain containing 109B
Band: 4q25
Quick LinksEntrez ID:55013; OMIM: NA; Uniprot ID:C109B_HUMAN; ENSEMBL ID: ENSG00000005059; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor15 / 26384556
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal77 / 336030722
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood4 / 12347832
bone3 / 7165541
bone marrow0 / 488010 
brain17 / 110098915
cervix3 / 4817162
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye5 / 21105423
heart4 / 8962644
intestine10 / 23447242
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung17 / 33697450
lymph2 / 4427045
lymph node18 / 91610196
mammary gland1 / 1532716
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate4 / 18934521
salivary gland5 / 20155248
skin1 / 2105744
spleen0 / 539520 
stomach4 / 9661941
testis6 / 33044218
thymus4 / 8113149
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218802_at
Cell line Expression level Expression bar
721_B_lymphoblasts119.75
Adipocyte8
AdrenalCortex8.6
Adrenalgland6.6
Amygdala8.1
Appendix8.45
AtrioventricularNode6.6
BDCA4+_DentriticCells353.6
Bonemarrow8.1
BronchialEpithelialCells12.2
CD105+_Endothelial67.15
CD14+_Monocytes332.3
CD19+_BCells(neg._sel.)636.4
CD33+_Myeloid387.7
CD34+32.55
CD4+_Tcells588.9
CD56+_NKCells222.3
CD71+_EarlyErythroid73.45
CD8+_Tcells473.7
CardiacMyocytes50.7
Caudatenucleus7.05
Cerebellum6.25
CerebellumPeduncles8.95
CiliaryGanglion5.85
CingulateCortex7.95
Colorectaladenocarcinoma30.95
DorsalRootGanglion6.25
FetalThyroid7.45
Fetalbrain32.95
Fetalliver6.85
Fetallung6.25
GlobusPallidus5.8
Heart10.65
Hypothalamus8.45
Kidney6.55
Leukemia_chronicMyelogenousK-56211.8
Leukemia_promyelocytic-HL-60373
Leukemialymphoblastic(MOLT-4)126.1
Liver10.65
Lung22
Lymphnode66.4
Lymphoma_burkitts(Daudi)604.55
Lymphoma_burkitts(Raji)104.65
MedullaOblongata6.8
OccipitalLobe6.75
OlfactoryBulb5.8
Ovary5.3
Pancreas6.3
PancreaticIslet42.4
ParietalLobe8.3
Pituitary9.45
Placenta11.05
Pons7.55
PrefrontalCortex8.5
Prostate10.15
Salivarygland7.8
SkeletalMuscle9.6
Skin7.3
SmoothMuscle65
Spinalcord14.25
SubthalamicNucleus7.05
SuperiorCervicalGanglion9.35
TemporalLobe7.15
Testis7.8
TestisGermCell6.1
TestisIntersitial6.35
TestisLeydigCell8.15
TestisSeminiferousTubule6.65
Thalamus7.9
Thymus168.65
Thyroid9.9
Tongue8.4
Tonsil27.9
Trachea6.8
TrigeminalGanglion8.2
Uterus24.8
UterusCorpus7.1
WholeBlood229.4
Wholebrain6.15
colon22.45
pineal_day9.34
pineal_night9.5
retina10.725
small_intestine16.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6015_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.44 ± 0.96
Basal Forebrain4.54 ± 0.31
Basal Part of Pons3.47 ± 0.59
Cerebellar Cortex3.29 ± 0.64
Cerebellar Nuclei4.19 ± 0.75
Claustrum4.28 ± 0.73
Epithalamus5.63 ± 0.43
Frontal Lobe4.3 ± 0.64
Globus Pallidus4.47 ± 1.08
Hypothalamus4.19 ± 0.73
Insula4.71 ± 0.63
Limbic Lobe4.1 ± 0.88
Mesencephalon4.14 ± 0.9
Myelencephalon4.1 ± 0.85
Occipital Lobe3.14 ± 0.91
Parietal Lobe3.86 ± 0.68
Pontine Tegmentum4.18 ± 0.67
Striatum3.92 ± 0.94
Subthalamus3.53 ± 0.55
Temporal Lobe4.3 ± 0.71
Thalamus3.95 ± 0.93
White Matter5.18 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ccdc109bCBCerebellum0.81
1.39
Ccdc109bCTXCerebral cortex0.83
1.05
Ccdc109bHIPHippocampal region3.95
4.23
Ccdc109bHPFHippocampal formation2.82
2.86
Ccdc109bHYHypothalamus1.83
2.24
Ccdc109bLSXLateral septal complex0.84
0.66
Ccdc109bMBMidbrain2.04
2.1
Ccdc109bMYMedulla0.79
1.02
Ccdc109bOLFOlfactory bulb2.49
2.37
Ccdc109bPPons0.47
0.92
Ccdc109bPALPallidum0.44
0.46
Ccdc109bRHPRetrohippocampal region1.25
1.22
Ccdc109bsAMYStriatum-like amygdalar nuclei0.16
0.21
Ccdc109bSTRStriatum0.26
0.31
Ccdc109bSTRdStriatum dorsal region0.19
0.26
Ccdc109bSTRvStriatum ventral region0.25
0.37
Ccdc109bTHThalamus3.4
3.87
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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