AutismKB 2.0

Annotation Detail for ZWILCH


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Basic Information Top
Gene Symbol:ZWILCH ( FLJ10036,FLJ16343,KNTC1AP,MGC111034,hZwilch )
Gene Full Name: Zwilch, kinetochore associated, homolog (Drosophila)
Band: 15q22.31
Quick LinksEntrez ID:55055; OMIM: 609984; Uniprot ID:ZWILC_HUMAN; ENSEMBL ID: ENSG00000174442; HGNC ID: 25468
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus52 / 56401292
neonate4 / 31097128
infant5 / 23620211
juvenile5 / 5555689
adult66 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor7 / 34366203
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor28 / 263845106
glioma6 / 10688356
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia9 / 9584293
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal200 / 336030759
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor17 / 124949136
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone5 / 7165569
bone marrow7 / 48801143
brain61 / 110098955
cervix7 / 48171145
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye5 / 21105423
heart3 / 8962633
intestine8 / 23447234
kidney10 / 21177747
larynx0 / 241450 
liver5 / 20774324
lung10 / 33697429
lymph1 / 4427022
lymph node4 / 9161043
mammary gland7 / 15327145
mouth4 / 6705259
muscle5 / 10771546
nerve1 / 1576863
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland1 / 2015549
skin31 / 210574147
spleen3 / 5395255
stomach5 / 9661951
testis143 / 330442432
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus17 / 23287872
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218349_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts146.8
Adipocyte7.6
AdrenalCortex6.3
Adrenalgland4.95
Amygdala5.5
Appendix6.2
AtrioventricularNode4.75
BDCA4+_DentriticCells9.8
Bonemarrow5.85
BronchialEpithelialCells12.8
CD105+_Endothelial67.5
CD14+_Monocytes6
CD19+_BCells(neg._sel.)8.85
CD33+_Myeloid7.3
CD34+76.2
CD4+_Tcells5.9
CD56+_NKCells22.3
CD71+_EarlyErythroid57
CD8+_Tcells10.45
CardiacMyocytes19.5
Caudatenucleus5
Cerebellum4.6
CerebellumPeduncles6.5
CiliaryGanglion4.5
CingulateCortex5.9
Colorectaladenocarcinoma5.75
DorsalRootGanglion4.7
FetalThyroid5.5
Fetalbrain5.7
Fetalliver5.65
Fetallung4.4
GlobusPallidus5.35
Heart8.05
Hypothalamus5.9
Kidney4.8
Leukemia_chronicMyelogenousK-56218.65
Leukemia_promyelocytic-HL-605.95
Leukemialymphoblastic(MOLT-4)14.95
Liver8
Lung6.05
Lymphnode4.65
Lymphoma_burkitts(Daudi)35.35
Lymphoma_burkitts(Raji)8.3
MedullaOblongata6.95
OccipitalLobe4.95
OlfactoryBulb4.4
Ovary3.95
Pancreas4.6
PancreaticIslet6
ParietalLobe6.35
Pituitary6.45
Placenta5.55
Pons5.5
PrefrontalCortex6.75
Prostate6.4
Salivarygland4.6
SkeletalMuscle7.55
Skin4.7
SmoothMuscle6.4
Spinalcord5.95
SubthalamicNucleus5.3
SuperiorCervicalGanglion7.35
TemporalLobe5.5
Testis9.9
TestisGermCell79.15
TestisIntersitial97.05
TestisLeydigCell77.8
TestisSeminiferousTubule50.65
Thalamus5.85
Thymus4.35
Thyroid6.8
Tongue5.9
Tonsil5.55
Trachea4.75
TrigeminalGanglion6.25
Uterus4.45
UterusCorpus5.25
WholeBlood6.1
Wholebrain4.4
colon5.85
pineal_day6.86
pineal_night6.76
retina6.775
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8581_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.64 ± 0.46
Basal Forebrain4.88 ± 0.35
Basal Part of Pons5.45 ± 0.33
Cerebellar Cortex5.33 ± 0.27
Cerebellar Nuclei4.96 ± 0.39
Claustrum5.89 ± 0.45
Epithalamus5.09 ± 0.41
Frontal Lobe5.15 ± 0.36
Globus Pallidus4.08 ± 0.48
Hypothalamus5.09 ± 0.83
Insula5.19 ± 0.27
Limbic Lobe5.13 ± 0.51
Mesencephalon5.03 ± 0.48
Myelencephalon5.03 ± 0.55
Occipital Lobe4.78 ± 0.67
Parietal Lobe5.14 ± 0.41
Pontine Tegmentum5.02 ± 0.51
Striatum4.54 ± 0.51
Subthalamus5.07 ± 0.74
Temporal Lobe5.36 ± 0.39
Thalamus4.8 ± 0.48
White Matter4 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ZwilchCBCerebellum7.43
9.82
ZwilchCTXCerebral cortex3.63
2.66
ZwilchHIPHippocampal region4.76
5.01
ZwilchHPFHippocampal formation4.15
3.92
ZwilchHYHypothalamus0.38
0.35
ZwilchLSXLateral septal complex1.83
1.96
ZwilchMBMidbrain1.73
2.1
ZwilchMYMedulla1.8
2.06
ZwilchOLFOlfactory bulb5.45
5.22
ZwilchPPons1.81
2.08
ZwilchPALPallidum0.95
0.68
ZwilchRHPRetrohippocampal region2.9
2
ZwilchsAMYStriatum-like amygdalar nuclei1.71
1.13
ZwilchSTRStriatum1.48
1.24
ZwilchSTRdStriatum dorsal region1.18
1
ZwilchSTRvStriatum ventral region1.93
1.31
ZwilchTHThalamus2.3
2.31
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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