AutismKB 2.0

Annotation Detail for PPP1R3C


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Basic Information Top
Gene Symbol:PPP1R3C ( PPP1R5 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 3C
Band: 10q23.32
Quick LinksEntrez ID:5507; OMIM: 602999; Uniprot ID:PPR3C_HUMAN; ENSEMBL ID: ENSG00000119938; HGNC ID: 9293
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus43 / 56401276
neonate4 / 31097128
infant3 / 23620127
juvenile2 / 5555635
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal271 / 336030780
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder5 / 29757168
blood0 / 1234780 
bone6 / 7165583
bone marrow1 / 4880120
brain71 / 110098964
cervix1 / 4817120
connective tissue33 / 149255221
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus2 / 2020998
eye5 / 21105423
heart28 / 89626312
intestine2 / 2344728
kidney30 / 211777141
larynx0 / 241450 
liver12 / 20774357
lung16 / 33697447
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth17 / 67052253
muscle12 / 107715111
nerve0 / 157680 
ovary2 / 10205119
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate15 / 18934579
salivary gland3 / 20155148
skin19 / 21057490
spleen3 / 5395255
stomach3 / 9661931
testis1 / 3304423
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea15 / 52413286
umbilical cord2 / 13680146
uterus15 / 23287864
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204284_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.9
Adipocyte129.6
AdrenalCortex12.1
Adrenalgland21.2
Amygdala53.5
Appendix21.35
AtrioventricularNode12.3
BDCA4+_DentriticCells5.1
Bonemarrow13.8
BronchialEpithelialCells21.55
CD105+_Endothelial4.7
CD14+_Monocytes5.1
CD19+_BCells(neg._sel.)5.5
CD33+_Myeloid7.45
CD34+5.5
CD4+_Tcells5.45
CD56+_NKCells5.8
CD71+_EarlyErythroid5.8
CD8+_Tcells7.5
CardiacMyocytes57.8
Caudatenucleus81.1
Cerebellum17.35
CerebellumPeduncles17.85
CiliaryGanglion14.65
CingulateCortex52.45
Colorectaladenocarcinoma8.65
DorsalRootGanglion15.9
FetalThyroid20.85
Fetalbrain35.75
Fetalliver104.25
Fetallung123.05
GlobusPallidus57.3
Heart40.85
Hypothalamus45.45
Kidney9.3
Leukemia_chronicMyelogenousK-56223.3
Leukemia_promyelocytic-HL-6010.15
Leukemialymphoblastic(MOLT-4)12.1
Liver63.8
Lung60.5
Lymphnode11.95
Lymphoma_burkitts(Daudi)18.9
Lymphoma_burkitts(Raji)10.8
MedullaOblongata71.4
OccipitalLobe70.9
OlfactoryBulb14
Ovary14.8
Pancreas15.1
PancreaticIslet78.65
ParietalLobe60.65
Pituitary25.35
Placenta22.55
Pons31
PrefrontalCortex131.35
Prostate30.7
Salivarygland21.85
SkeletalMuscle537.6
Skin22.35
SmoothMuscle62.15
Spinalcord30.55
SubthalamicNucleus50.7
SuperiorCervicalGanglion18
TemporalLobe50.95
Testis21.7
TestisGermCell23.7
TestisIntersitial16
TestisLeydigCell16.05
TestisSeminiferousTubule13.9
Thalamus40.25
Thymus10.1
Thyroid31.25
Tongue672.4
Tonsil15.7
Trachea515.5
TrigeminalGanglion14.7
Uterus49.55
UterusCorpus16.5
WholeBlood11.75
Wholebrain129.3
colon21.75
pineal_day21.72
pineal_night44.18
retina99.45
small_intestine20.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7441_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.21 ± 0.68
Basal Forebrain9.05 ± 0.53
Basal Part of Pons8.54 ± 0.6
Cerebellar Cortex8.24 ± 0.49
Cerebellar Nuclei8.87 ± 0.47
Claustrum9.4 ± 0.78
Epithalamus8.29 ± 0.43
Frontal Lobe8.74 ± 0.61
Globus Pallidus9.34 ± 0.33
Hypothalamus8.89 ± 0.78
Insula8.53 ± 0.54
Limbic Lobe8.78 ± 0.66
Mesencephalon9.01 ± 0.6
Myelencephalon8.78 ± 0.64
Occipital Lobe8.86 ± 0.73
Parietal Lobe8.76 ± 0.53
Pontine Tegmentum8.71 ± 0.57
Striatum9.19 ± 0.54
Subthalamus8.72 ± 0.32
Temporal Lobe8.63 ± 0.73
Thalamus8.75 ± 0.57
White Matter9.09 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1r3cCBCerebellum16.48
19.71
Ppp1r3cCTXCerebral cortex76.71
56.96
Ppp1r3cHIPHippocampal region28.95
28.46
Ppp1r3cHPFHippocampal formation38.39
33.17
Ppp1r3cHYHypothalamus20.88
15.11
Ppp1r3cLSXLateral septal complex62.35
43.48
Ppp1r3cMBMidbrain18.5
17.94
Ppp1r3cMYMedulla21.09
21.73
Ppp1r3cOLFOlfactory bulb80.45
68.29
Ppp1r3cPPons19.05
20.35
Ppp1r3cPALPallidum27.59
21.88
Ppp1r3cRHPRetrohippocampal region51.87
38.45
Ppp1r3csAMYStriatum-like amygdalar nuclei35.52
23.49
Ppp1r3cSTRStriatum51.96
36.38
Ppp1r3cSTRdStriatum dorsal region49.69
35.69
Ppp1r3cSTRvStriatum ventral region64.06
41.72
Ppp1r3cTHThalamus19.94
17.76
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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