AutismKB 2.0

Annotation Detail for TMEM45A


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Basic Information Top
Gene Symbol:TMEM45A ( DERP7,FLJ10134 )
Gene Full Name: transmembrane protein 45A
Band: 3q12.2
Quick LinksEntrez ID:55076; OMIM: NA; Uniprot ID:TM45A_HUMAN; ENSEMBL ID: ENSG00000181458; HGNC ID: 25480
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult137 / 193912170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal119 / 336030735
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor90 / 125191718
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow3 / 4880161
brain13 / 110098911
cervix2 / 4817141
connective tissue91 / 149255609
ear1 / 1621261
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye5 / 21105423
heart2 / 8962622
intestine4 / 23447217
kidney1 / 2117774
larynx0 / 241450 
liver3 / 20774314
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx8 / 41328193
pituitary gland1 / 1658560
placenta21 / 28082574
prostate1 / 1893455
salivary gland0 / 201550 
skin25 / 210574118
spleen1 / 5395218
stomach1 / 9661910
testis8 / 33044224
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219410_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte370.4
AdrenalCortex5
Adrenalgland14.65
Amygdala4.75
Appendix7
AtrioventricularNode4.4
BDCA4+_DentriticCells4.6
Bonemarrow4.9
BronchialEpithelialCells33.65
CD105+_Endothelial4.95
CD14+_Monocytes4.7
CD19+_BCells(neg._sel.)4.6
CD33+_Myeloid6.25
CD34+5.85
CD4+_Tcells4.9
CD56+_NKCells5.1
CD71+_EarlyErythroid4.2
CD8+_Tcells4.15
CardiacMyocytes30.05
Caudatenucleus5.5
Cerebellum3.65
CerebellumPeduncles5.2
CiliaryGanglion3.45
CingulateCortex4.7
Colorectaladenocarcinoma4.6
DorsalRootGanglion3.8
FetalThyroid5.45
Fetalbrain4.4
Fetalliver4
Fetallung21.55
GlobusPallidus3.4
Heart6.15
Hypothalamus5.1
Kidney3.8
Leukemia_chronicMyelogenousK-5624.15
Leukemia_promyelocytic-HL-603.9
Leukemialymphoblastic(MOLT-4)3.55
Liver6.65
Lung5.45
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.85
Lymphoma_burkitts(Raji)6.55
MedullaOblongata4.25
OccipitalLobe4.1
OlfactoryBulb4.35
Ovary6.85
Pancreas4.35
PancreaticIslet44.45
ParietalLobe4.9
Pituitary86.05
Placenta260.2
Pons4.75
PrefrontalCortex5.4
Prostate5.6
Salivarygland36.1
SkeletalMuscle5.45
Skin638.55
SmoothMuscle289.05
Spinalcord5.45
SubthalamicNucleus4.2
SuperiorCervicalGanglion6.05
TemporalLobe4.3
Testis11.95
TestisGermCell20.9
TestisIntersitial5.8
TestisLeydigCell5.05
TestisSeminiferousTubule4.25
Thalamus4.7
Thymus3.5
Thyroid7.35
Tongue6.95
Tonsil97.65
Trachea32.9
TrigeminalGanglion5.5
Uterus20.95
UterusCorpus4.15
WholeBlood4.85
Wholebrain3.95
colon4.95
pineal_day6.22
pineal_night9.22
retina10.025
small_intestine4.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1300_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.89 ± 1.03
Basal Forebrain2.6 ± 0.43
Basal Part of Pons2.04 ± 0.46
Cerebellar Cortex1.86 ± 0.31
Cerebellar Nuclei2.72 ± 0.87
Claustrum3.01 ± 0.68
Epithalamus2.52 ± 0.76
Frontal Lobe2.3 ± 0.84
Globus Pallidus3.26 ± 0.41
Hypothalamus2.66 ± 0.88
Insula1.95 ± 0.52
Limbic Lobe2.29 ± 0.71
Mesencephalon2.62 ± 0.88
Myelencephalon2.53 ± 0.8
Occipital Lobe2.31 ± 0.72
Parietal Lobe2.29 ± 0.69
Pontine Tegmentum2.62 ± 0.91
Striatum4.73 ± 0.68
Subthalamus2.66 ± 0.89
Temporal Lobe2.36 ± 0.72
Thalamus2.41 ± 0.72
White Matter2.59 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem45aCBCerebellum0
0
Tmem45aCTXCerebral cortex0
0
Tmem45aHIPHippocampal region0
0
Tmem45aHPFHippocampal formation0
0
Tmem45aHYHypothalamus0
0
Tmem45aLSXLateral septal complex0
0
Tmem45aMBMidbrain0
0
Tmem45aMYMedulla0
0
Tmem45aOLFOlfactory bulb0
0
Tmem45aPPons0
0
Tmem45aPALPallidum0
0
Tmem45aRHPRetrohippocampal region0
0
Tmem45asAMYStriatum-like amygdalar nuclei0
0
Tmem45aSTRStriatum0
0
Tmem45aSTRdStriatum dorsal region0
0
Tmem45aSTRvStriatum ventral region0
0
Tmem45aTHThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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