AutismKB 2.0

Annotation Detail for PPP1R7


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Basic Information Top
Gene Symbol:PPP1R7 ( SDS22 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 7
Band: 2q37.3
Quick LinksEntrez ID:5510; OMIM: 602877; Uniprot ID:PP1R7_HUMAN; ENSEMBL ID: ENSG00000115685; HGNC ID: 9295
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst6 / 6231996
fetus49 / 56401286
neonate4 / 31097128
infant2 / 2362084
juvenile3 / 5555653
adult201 / 1939121103
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor6 / 34366174
chondrosarcoma15 / 82823181
colorectal tumor14 / 114246122
esophageal tumor0 / 172900 
gastrointestinal tumor12 / 119369100
germ cell tumor16 / 26384560
glioma16 / 106883149
head and neck tumor13 / 13630295
kidney tumor5 / 6895972
leukemia12 / 95842125
liver tumor10 / 96359103
lung tumor13 / 103127126
lymphoma20 / 71755278
non-neoplasia12 / 97250123
normal296 / 336030788
ovarian tumor14 / 76682182
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer14 / 102680136
retinoblastoma2 / 4635643
skin tumor17 / 124949136
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites7 / 40015174
bladder1 / 2975733
blood9 / 12347872
bone13 / 71655181
bone marrow9 / 48801184
brain114 / 1100989103
cervix6 / 48171124
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue20 / 21572292
esophagus0 / 202090 
eye25 / 211054118
heart7 / 8962678
intestine25 / 234472106
kidney22 / 211777103
larynx0 / 241450 
liver21 / 207743101
lung47 / 336974139
lymph16 / 44270361
lymph node8 / 9161087
mammary gland16 / 153271104
mouth2 / 6705229
muscle14 / 107715129
nerve2 / 15768126
ovary18 / 102051176
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta15 / 28082553
prostate27 / 189345142
salivary gland3 / 20155148
skin26 / 210574123
spleen1 / 5395218
stomach4 / 9661941
testis46 / 330442139
thymus0 / 811310 
thyroid10 / 47473210
tonsil9 / 16999529
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213465_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts398.25
Adipocyte68.7
AdrenalCortex25.25
Adrenalgland31.5
Amygdala85.15
Appendix41.8
AtrioventricularNode7.5
BDCA4+_DentriticCells208.95
Bonemarrow45.35
BronchialEpithelialCells169.55
CD105+_Endothelial215.5
CD14+_Monocytes296.05
CD19+_BCells(neg._sel.)273.45
CD33+_Myeloid271.85
CD34+164.65
CD4+_Tcells121.35
CD56+_NKCells352.45
CD71+_EarlyErythroid172.35
CD8+_Tcells107.9
CardiacMyocytes108.75
Caudatenucleus156.4
Cerebellum59.75
CerebellumPeduncles87.85
CiliaryGanglion11.9
CingulateCortex92.95
Colorectaladenocarcinoma71.2
DorsalRootGanglion10.55
FetalThyroid72.45
Fetalbrain46.15
Fetalliver33.75
Fetallung41.1
GlobusPallidus47.7
Heart43.1
Hypothalamus76.3
Kidney41.1
Leukemia_chronicMyelogenousK-56257.55
Leukemia_promyelocytic-HL-6087.25
Leukemialymphoblastic(MOLT-4)64.5
Liver56.25
Lung77.15
Lymphnode38.4
Lymphoma_burkitts(Daudi)69.3
Lymphoma_burkitts(Raji)50.05
MedullaOblongata110.95
OccipitalLobe127.95
OlfactoryBulb39.35
Ovary10.1
Pancreas29.1
PancreaticIslet69
ParietalLobe107.75
Pituitary59.4
Placenta51.5
Pons83.65
PrefrontalCortex164.6
Prostate144.9
Salivarygland40.45
SkeletalMuscle41.9
Skin6.15
SmoothMuscle132.25
Spinalcord49.1
SubthalamicNucleus69.7
SuperiorCervicalGanglion15.9
TemporalLobe107
Testis331.45
TestisGermCell531.65
TestisIntersitial676.85
TestisLeydigCell439.55
TestisSeminiferousTubule331.2
Thalamus86
Thymus72.9
Thyroid32.5
Tongue50.05
Tonsil52.3
Trachea35.65
TrigeminalGanglion20.5
Uterus19.7
UterusCorpus30.85
WholeBlood101.9
Wholebrain214.1
colon66.15
pineal_day122.18
pineal_night106.34
retina90.925
small_intestine57.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1969_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.07 ± 0.25
Basal Forebrain8.82 ± 0.2
Basal Part of Pons9.04 ± 0.19
Cerebellar Cortex8.55 ± 0.13
Cerebellar Nuclei8.66 ± 0.27
Claustrum9.22 ± 0.2
Epithalamus8.73 ± 0.24
Frontal Lobe8.92 ± 0.26
Globus Pallidus8.19 ± 0.54
Hypothalamus8.63 ± 0.34
Insula8.85 ± 0.26
Limbic Lobe8.95 ± 0.42
Mesencephalon8.66 ± 0.34
Myelencephalon8.81 ± 0.4
Occipital Lobe8.56 ± 0.35
Parietal Lobe8.83 ± 0.3
Pontine Tegmentum8.81 ± 0.24
Striatum9.52 ± 0.26
Subthalamus8.81 ± 0.07
Temporal Lobe8.91 ± 0.29
Thalamus8.56 ± 0.2
White Matter8.15 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1r7CBCerebellum12.95
11.11
Ppp1r7CTXCerebral cortex18.51
12.57
Ppp1r7HIPHippocampal region47.23
28.22
Ppp1r7HPFHippocampal formation38.04
23.83
Ppp1r7HYHypothalamus3.25
1.75
Ppp1r7LSXLateral septal complex7.8
4.67
Ppp1r7MBMidbrain2.89
2.33
Ppp1r7MYMedulla8.83
6.8
Ppp1r7OLFOlfactory bulb31.06
19.52
Ppp1r7PPons6.54
5.17
Ppp1r7PALPallidum9.51
6.29
Ppp1r7RHPRetrohippocampal region24.32
17.64
Ppp1r7sAMYStriatum-like amygdalar nuclei21.27
13.89
Ppp1r7STRStriatum54.55
33.4
Ppp1r7STRdStriatum dorsal region59.88
36.91
Ppp1r7STRvStriatum ventral region78.84
45.68
Ppp1r7THThalamus3.56
2.14
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001071 12 112 123 CIENLEELQSLR Peptide Atlas
PP1R7_HUMAN_0 0 0 0 AIENIDTLTNLESLFLGK PRIDE
PP1R7_HUMAN_199 18 199 216 AIENIDTLTNLESLFLGK PRIDE
PP1R7_HUMAN_5 15 5 19 GAGQQQSQEMMEVDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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