AutismKB 2.0

Annotation Detail for ARHGEF10L


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Basic Information Top
Gene Symbol:ARHGEF10L ( FLJ10521,GrinchGEF,KIAA1626 )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 10-like
Band: 1p36.13
Quick LinksEntrez ID:55160; OMIM: 612494; Uniprot ID:ARGAL_HUMAN; ENSEMBL ID: ENSG00000074964; HGNC ID: 25540
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus11 / 56401219
neonate2 / 3109764
infant2 / 2362084
juvenile0 / 555560 
adult56 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor4 / 26384515
glioma4 / 10688337
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia13 / 97250133
normal106 / 336030731
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain46 / 110098941
cervix0 / 481710 
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye10 / 21105447
heart1 / 8962611
intestine15 / 23447263
kidney8 / 21177737
larynx0 / 241450 
liver6 / 20774328
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta9 / 28082532
prostate2 / 18934510
salivary gland0 / 201550 
skin8 / 21057437
spleen2 / 5395237
stomach6 / 9661962
testis4 / 33044212
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221656_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts73.35
Adipocyte50.85
AdrenalCortex47.9
Adrenalgland43.8
Amygdala53.55
Appendix55.15
AtrioventricularNode38.15
BDCA4+_DentriticCells60.45
Bonemarrow50.25
BronchialEpithelialCells47.85
CD105+_Endothelial54
CD14+_Monocytes250.1
CD19+_BCells(neg._sel.)52.8
CD33+_Myeloid151.5
CD34+46.05
CD4+_Tcells54.4
CD56+_NKCells42.05
CD71+_EarlyErythroid47.75
CD8+_Tcells44.15
CardiacMyocytes53.65
Caudatenucleus57.75
Cerebellum138.1
CerebellumPeduncles302.7
CiliaryGanglion37.5
CingulateCortex86.4
Colorectaladenocarcinoma48.5
DorsalRootGanglion38.8
FetalThyroid65.4
Fetalbrain80.15
Fetalliver68.65
Fetallung48.75
GlobusPallidus37.75
Heart222.85
Hypothalamus133.65
Kidney98.6
Leukemia_chronicMyelogenousK-56245.4
Leukemia_promyelocytic-HL-6047.45
Leukemialymphoblastic(MOLT-4)43.15
Liver201.35
Lung220.65
Lymphnode44.95
Lymphoma_burkitts(Daudi)66.2
Lymphoma_burkitts(Raji)72.6
MedullaOblongata51.85
OccipitalLobe55.95
OlfactoryBulb47.2
Ovary34.6
Pancreas95.45
PancreaticIslet185.15
ParietalLobe57.95
Pituitary64
Placenta54.5
Pons53.45
PrefrontalCortex86.75
Prostate106.8
Salivarygland76.8
SkeletalMuscle85.05
Skin80.2
SmoothMuscle56.5
Spinalcord73.75
SubthalamicNucleus69.3
SuperiorCervicalGanglion55.05
TemporalLobe52.65
Testis50.65
TestisGermCell44
TestisIntersitial35.4
TestisLeydigCell51.75
TestisSeminiferousTubule44.85
Thalamus87.4
Thymus34.6
Thyroid138.8
Tongue105.05
Tonsil72.05
Trachea58.35
TrigeminalGanglion66.5
Uterus58.2
UterusCorpus50.9
WholeBlood81.35
Wholebrain59.5
colon105.45
pineal_day87.84
pineal_night95.08
retina118.3
small_intestine86.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P386
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.22 ± 0.39
Basal Forebrain8.53 ± 0.33
Basal Part of Pons9.22 ± 0.25
Cerebellar Cortex9.33 ± 0.32
Cerebellar Nuclei9.05 ± 0.37
Claustrum7.84 ± 0.39
Epithalamus8.95 ± 0.39
Frontal Lobe8.71 ± 0.43
Globus Pallidus8.88 ± 0.56
Hypothalamus8.74 ± 0.38
Insula8.65 ± 0.31
Limbic Lobe8.51 ± 0.38
Mesencephalon8.73 ± 0.54
Myelencephalon8.76 ± 0.55
Occipital Lobe9 ± 0.48
Parietal Lobe8.84 ± 0.43
Pontine Tegmentum8.61 ± 0.35
Striatum8.69 ± 0.43
Subthalamus8.9 ± 0.15
Temporal Lobe8.6 ± 0.32
Thalamus9.12 ± 0.45
White Matter7.48 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arhgef10lCBCerebellum43.18
44.1
Arhgef10lCTXCerebral cortex63.8
26.58
Arhgef10lHIPHippocampal region14.18
9.65
Arhgef10lHPFHippocampal formation18.79
9.93
Arhgef10lHYHypothalamus34.6
12.04
Arhgef10lLSXLateral septal complex15.98
5.44
Arhgef10lMBMidbrain46.64
22.49
Arhgef10lMYMedulla53.67
35.71
Arhgef10lOLFOlfactory bulb28.89
12.23
Arhgef10lPPons55.12
33.51
Arhgef10lPALPallidum38.35
17.28
Arhgef10lRHPRetrohippocampal region25.54
10.13
Arhgef10lsAMYStriatum-like amygdalar nuclei29.57
12.67
Arhgef10lSTRStriatum22.84
8.76
Arhgef10lSTRdStriatum dorsal region18.91
7.46
Arhgef10lSTRvStriatum ventral region37.24
12.58
Arhgef10lTHThalamus49.02
19.8
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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