AutismKB 2.0

Annotation Detail for MSL2


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Basic Information Top
Gene Symbol:MSL2 ( FLJ10546,FLJ54913,KIAA1585,MSL-2,MSL2L1,RNF184 )
Gene Full Name: male-specific lethal 2 homolog (Drosophila)
Band: 3q22.3
Quick LinksEntrez ID:55167; OMIM: NA; Uniprot ID:MSL2_HUMAN; ENSEMBL ID: ENSG00000174579; HGNC ID: 25544
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor6 / 26384522
glioma0 / 1068830 
head and neck tumor8 / 13630258
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal56 / 336030716
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine12 / 23447251
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung8 / 33697423
lymph0 / 442700 
lymph node1 / 9161010
mammary gland6 / 15327139
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate4 / 18934521
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach7 / 9661972
testis9 / 33044227
thymus15 / 81131184
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218733_at
Cell line Expression level Expression bar
721_B_lymphoblasts57.05
Adipocyte13.35
AdrenalCortex12.7
Adrenalgland8.8
Amygdala10.65
Appendix17.2
AtrioventricularNode10.85
BDCA4+_DentriticCells65.15
Bonemarrow13.9
BronchialEpithelialCells12.7
CD105+_Endothelial33.05
CD14+_Monocytes48.25
CD19+_BCells(neg._sel.)175.5
CD33+_Myeloid69.45
CD34+93.05
CD4+_Tcells109.05
CD56+_NKCells116
CD71+_EarlyErythroid15.1
CD8+_Tcells127.85
CardiacMyocytes14
Caudatenucleus8.95
Cerebellum10.8
CerebellumPeduncles21.95
CiliaryGanglion10.05
CingulateCortex12.35
Colorectaladenocarcinoma8.5
DorsalRootGanglion10.95
FetalThyroid13.8
Fetalbrain11.15
Fetalliver20.85
Fetallung10.6
GlobusPallidus8.15
Heart15.85
Hypothalamus17
Kidney8.95
Leukemia_chronicMyelogenousK-5629.4
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)63.25
Liver16.1
Lung11.05
Lymphnode14.25
Lymphoma_burkitts(Daudi)23.7
Lymphoma_burkitts(Raji)14.45
MedullaOblongata15.1
OccipitalLobe9.4
OlfactoryBulb11.45
Ovary7.85
Pancreas14.05
PancreaticIslet15.95
ParietalLobe12.75
Pituitary20.15
Placenta20.25
Pons11.85
PrefrontalCortex18.55
Prostate14
Salivarygland23.75
SkeletalMuscle15.85
Skin15.3
SmoothMuscle10
Spinalcord10.5
SubthalamicNucleus11.15
SuperiorCervicalGanglion17
TemporalLobe11.25
Testis21.15
TestisGermCell27.2
TestisIntersitial15.95
TestisLeydigCell13.1
TestisSeminiferousTubule17.4
Thalamus10.8
Thymus109.6
Thyroid12.95
Tongue10.8
Tonsil44.25
Trachea11.9
TrigeminalGanglion12.5
Uterus16.65
UterusCorpus12.65
WholeBlood106.1
Wholebrain10.15
colon12.15
pineal_day25.38
pineal_night25.8
retina19.625
small_intestine11.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P132438
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.4 ± 0.65
Basal Forebrain4.54 ± 0.15
Basal Part of Pons4.5 ± 0.25
Cerebellar Cortex5.03 ± 0.24
Cerebellar Nuclei4.84 ± 0.67
Claustrum4.27 ± 0.65
Epithalamus4.75 ± 0.63
Frontal Lobe4.59 ± 0.45
Globus Pallidus4.55 ± 0.57
Hypothalamus4.56 ± 0.5
Insula4.7 ± 0.36
Limbic Lobe4.34 ± 0.43
Mesencephalon4.66 ± 0.49
Myelencephalon4.59 ± 0.53
Occipital Lobe4.7 ± 0.41
Parietal Lobe4.59 ± 0.54
Pontine Tegmentum4.6 ± 0.51
Striatum4.46 ± 0.5
Subthalamus4.57 ± 0.32
Temporal Lobe4.51 ± 0.49
Thalamus4.62 ± 0.49
White Matter5.34 ± 0.29
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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