AutismKB 2.0

Annotation Detail for PPP2R1B


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Basic Information Top
Gene Symbol:PPP2R1B ( MGC26454,PP2A-Abeta,PR65B )
Gene Full Name: protein phosphatase 2, regulatory subunit A, beta
Band: 11q23.1
Quick LinksEntrez ID:5519; OMIM: 603113; Uniprot ID:2AAB_HUMAN; ENSEMBL ID: ENSG00000137713; HGNC ID: 9303
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst11 / 62319176
fetus53 / 56401293
neonate2 / 3109764
infant0 / 236200 
juvenile7 / 55556125
adult88 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor34 / 263845128
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor8 / 9635983
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal288 / 336030785
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland2 / 3319760
ascites4 / 4001599
bladder4 / 29757134
blood7 / 12347856
bone3 / 7165541
bone marrow2 / 4880140
brain70 / 110098963
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus0 / 202090 
eye7 / 21105433
heart2 / 8962622
intestine5 / 23447221
kidney20 / 21177794
larynx0 / 241450 
liver10 / 20774348
lung21 / 33697462
lymph2 / 4427045
lymph node9 / 9161098
mammary gland7 / 15327145
mouth5 / 6705274
muscle0 / 1077150 
nerve1 / 1576863
ovary4 / 10205139
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland2 / 16585120
placenta14 / 28082549
prostate1 / 1893455
salivary gland2 / 2015599
skin13 / 21057461
spleen3 / 5395255
stomach3 / 9661931
testis102 / 330442308
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord1 / 1368073
uterus9 / 23287838
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202884_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts21
Adipocyte10
AdrenalCortex13.5
Adrenalgland7.65
Amygdala8.65
Appendix11.75
AtrioventricularNode8.1
BDCA4+_DentriticCells11.05
Bonemarrow10.9
BronchialEpithelialCells14.5
CD105+_Endothelial11.5
CD14+_Monocytes8.85
CD19+_BCells(neg._sel.)12.1
CD33+_Myeloid10.2
CD34+9.75
CD4+_Tcells10.4
CD56+_NKCells9.25
CD71+_EarlyErythroid26.5
CD8+_Tcells7.5
CardiacMyocytes18.75
Caudatenucleus7.65
Cerebellum7.05
CerebellumPeduncles10.65
CiliaryGanglion6.15
CingulateCortex9.15
Colorectaladenocarcinoma8.6
DorsalRootGanglion6.55
FetalThyroid8.1
Fetalbrain8.25
Fetalliver8.9
Fetallung6.8
GlobusPallidus6.2
Heart18.75
Hypothalamus8.65
Kidney8
Leukemia_chronicMyelogenousK-5627.75
Leukemia_promyelocytic-HL-609.25
Leukemialymphoblastic(MOLT-4)10.75
Liver15.8
Lung9.3
Lymphnode7
Lymphoma_burkitts(Daudi)10.65
Lymphoma_burkitts(Raji)13.95
MedullaOblongata7.55
OccipitalLobe7.5
OlfactoryBulb6.4
Ovary10.85
Pancreas7.45
PancreaticIslet22.65
ParietalLobe9.75
Pituitary10.1
Placenta8.3
Pons7.95
PrefrontalCortex10.3
Prostate10.15
Salivarygland7.4
SkeletalMuscle14.85
Skin6.65
SmoothMuscle11.75
Spinalcord8.9
SubthalamicNucleus8.55
SuperiorCervicalGanglion14.55
TemporalLobe8.9
Testis35.8
TestisGermCell47.35
TestisIntersitial62.95
TestisLeydigCell34.15
TestisSeminiferousTubule44.3
Thalamus8.65
Thymus8.3
Thyroid9.95
Tongue10.5
Tonsil8.2
Trachea7.25
TrigeminalGanglion13.55
Uterus7
UterusCorpus9.15
WholeBlood8.6
Wholebrain6.95
colon8.6
pineal_day14.22
pineal_night24.36
retina10.225
small_intestine8.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P98762
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.49 ± 1.04
Basal Forebrain2.03 ± 0.18
Basal Part of Pons1.96 ± 0.67
Cerebellar Cortex2.38 ± 0.64
Cerebellar Nuclei2.34 ± 0.76
Claustrum2.83 ± 0.69
Epithalamus2.01 ± 0.59
Frontal Lobe1.93 ± 0.61
Globus Pallidus2.58 ± 0.54
Hypothalamus2.14 ± 0.78
Insula1.99 ± 0.7
Limbic Lobe2.04 ± 0.61
Mesencephalon2.22 ± 0.71
Myelencephalon2.14 ± 0.71
Occipital Lobe2.23 ± 0.82
Parietal Lobe2.12 ± 0.69
Pontine Tegmentum2.07 ± 0.68
Striatum2.21 ± 0.69
Subthalamus2.2 ± 0.61
Temporal Lobe1.92 ± 0.62
Thalamus2.1 ± 0.59
White Matter2.99 ± 0.77
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp2r1bCBCerebellum1.49
1.54
Ppp2r1bCTXCerebral cortex3.25
2.27
Ppp2r1bHIPHippocampal region1.42
1.26
Ppp2r1bHPFHippocampal formation1.9
1.61
Ppp2r1bHYHypothalamus0.13
0.2
Ppp2r1bLSXLateral septal complex0.04
0
Ppp2r1bMBMidbrain0.35
0.36
Ppp2r1bMYMedulla2.69
3.25
Ppp2r1bOLFOlfactory bulb1.81
2.71
Ppp2r1bPPons2.35
2.94
Ppp2r1bPALPallidum0.59
0.59
Ppp2r1bRHPRetrohippocampal region3.02
2.33
Ppp2r1bsAMYStriatum-like amygdalar nuclei0.79
0.64
Ppp2r1bSTRStriatum0.67
0.51
Ppp2r1bSTRdStriatum dorsal region0.86
0.68
Ppp2r1bSTRvStriatum ventral region0.28
0.19
Ppp2r1bTHThalamus0.31
0.26
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
2AAB_HUMAN_126 21 126 146 QISQEHTPVALEAYFVPLVKR PRIDE
2AAB_HUMAN_2 32 2 33 AGASELGTGPGAAGGDGDDSLYPIAVLIDELR PRIDE
2AAB_HUMAN_532 8 532 539 QMLPIVLK PRIDE
PAp00005180 17 394 410 LNIISNLDCVNEVIGIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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