AutismKB 2.0

Annotation Detail for PPP2R2A


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Basic Information Top
Gene Symbol:PPP2R2A ( B55A,B55ALPHA,DKFZp686N05117,FLJ26613,FLJ41727,MGC52248,PR52A,PR55A )
Gene Full Name: protein phosphatase 2, regulatory subunit B, alpha
Band: 8p21.2
Quick LinksEntrez ID:5520; OMIM: 604941; Uniprot ID:2ABA_HUMAN; ENSEMBL ID: ENSG00000221914; HGNC ID: 9304
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus43 / 56401276
neonate4 / 31097128
infant2 / 2362084
juvenile9 / 55556161
adult150 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor16 / 26384560
glioma16 / 106883149
head and neck tumor4 / 13630229
kidney tumor6 / 6895987
leukemia7 / 9584273
liver tumor7 / 9635972
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal256 / 336030776
ovarian tumor5 / 7668265
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer8 / 10268077
retinoblastoma2 / 4635643
skin tumor9 / 12494972
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites4 / 4001599
bladder5 / 29757168
blood9 / 12347872
bone3 / 7165541
bone marrow2 / 4880140
brain83 / 110098975
cervix2 / 4817141
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye11 / 21105452
heart5 / 8962655
intestine18 / 23447276
kidney13 / 21177761
larynx2 / 2414582
liver12 / 20774357
lung30 / 33697489
lymph0 / 442700 
lymph node9 / 9161098
mammary gland6 / 15327139
mouth2 / 6705229
muscle8 / 10771574
nerve0 / 157680 
ovary7 / 10205168
pancreas17 / 21481279
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta32 / 280825113
prostate19 / 189345100
salivary gland0 / 201550 
skin20 / 21057494
spleen2 / 5395237
stomach8 / 9661982
testis36 / 330442108
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus20 / 23287885
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202313_at
Cell line Expression level Expression bar
721_B_lymphoblasts147.6
Adipocyte22.85
AdrenalCortex8.25
Adrenalgland10.25
Amygdala48.25
Appendix21.5
AtrioventricularNode10.2
BDCA4+_DentriticCells52.95
Bonemarrow10.8
BronchialEpithelialCells94.4
CD105+_Endothelial26.85
CD14+_Monocytes62.4
CD19+_BCells(neg._sel.)77.95
CD33+_Myeloid46.3
CD34+44.3
CD4+_Tcells71.6
CD56+_NKCells60.85
CD71+_EarlyErythroid31.3
CD8+_Tcells63.6
CardiacMyocytes41.05
Caudatenucleus33.55
Cerebellum16.05
CerebellumPeduncles8.95
CiliaryGanglion4.75
CingulateCortex20.75
Colorectaladenocarcinoma24.2
DorsalRootGanglion9
FetalThyroid20.6
Fetalbrain21.2
Fetalliver11.4
Fetallung46.1
GlobusPallidus13.3
Heart10.75
Hypothalamus60.35
Kidney7.85
Leukemia_chronicMyelogenousK-56247.5
Leukemia_promyelocytic-HL-6092.35
Leukemialymphoblastic(MOLT-4)107.2
Liver8.4
Lung15.5
Lymphnode18.45
Lymphoma_burkitts(Daudi)104.95
Lymphoma_burkitts(Raji)29.15
MedullaOblongata35.5
OccipitalLobe42
OlfactoryBulb24.35
Ovary19.95
Pancreas11.4
PancreaticIslet26.2
ParietalLobe39.35
Pituitary22.2
Placenta40.75
Pons16.75
PrefrontalCortex68.65
Prostate27.45
Salivarygland24.65
SkeletalMuscle11.2
Skin8.85
SmoothMuscle52.75
Spinalcord36.95
SubthalamicNucleus20.4
SuperiorCervicalGanglion20.5
TemporalLobe24.45
Testis14.9
TestisGermCell53.45
TestisIntersitial24.85
TestisLeydigCell30.8
TestisSeminiferousTubule30.95
Thalamus34.3
Thymus23.8
Thyroid26.65
Tongue22.6
Tonsil48.95
Trachea32.45
TrigeminalGanglion12.15
Uterus21
UterusCorpus11.6
WholeBlood83.05
Wholebrain45.5
colon11.55
pineal_day62.84
pineal_night47.14
retina37.525
small_intestine20.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8931_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.66 ± 0.44
Basal Forebrain6.86 ± 0.17
Basal Part of Pons6.77 ± 0.15
Cerebellar Cortex6.48 ± 0.17
Cerebellar Nuclei7 ± 0.29
Claustrum6.92 ± 0.33
Epithalamus6.65 ± 0.25
Frontal Lobe6.89 ± 0.33
Globus Pallidus7.04 ± 0.24
Hypothalamus6.96 ± 0.22
Insula6.67 ± 0.2
Limbic Lobe6.87 ± 0.46
Mesencephalon6.88 ± 0.4
Myelencephalon6.84 ± 0.4
Occipital Lobe6.65 ± 0.4
Parietal Lobe6.84 ± 0.36
Pontine Tegmentum6.95 ± 0.27
Striatum7.63 ± 0.3
Subthalamus7.02 ± 0.5
Temporal Lobe6.76 ± 0.26
Thalamus6.8 ± 0.33
White Matter7.87 ± 0.29
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
2ABA_HUMAN_153 16 153 168 VPVFRPMDLMVEASPR PRIDE
2ABA_HUMAN_159 11 159 169 PMDLMVEASPR PRIDE
2ABA_HUMAN_267 11 267 277 LFEEPEDPSNR PRIDE
2ABA_HUMAN_278 14 278 291 SFFSEIISSISDVK PRIDE
2ABA_HUMAN_309 21 309 329 IWDLNMENRPVETYQVHEYLR PRIDE
PAp00041183 15 414 428 KKDEISVDSLDFNKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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