AutismKB 2.0

Annotation Detail for PPP2R2B


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Basic Information Top
Gene Symbol:PPP2R2B ( B55BETA,FLJ95686,MGC24888,PP2AB55BETA,PP2ABBETA,PP2APR55B,PP2APR55BETA,PR2AB55BETA,PR2ABBETA,PR2APR55BETA,PR52B,PR55-BETA,PR55BETA,SCA12 )
Gene Full Name: protein phosphatase 2, regulatory subunit B, beta
Band: 5q32
Quick LinksEntrez ID:5521; OMIM: 604325; Uniprot ID:2ABB_HUMAN; ENSEMBL ID: ENSG00000156475; HGNC ID: 9305
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus42 / 56401274
neonate1 / 3109732
infant2 / 2362084
juvenile3 / 5555653
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor18 / 26384568
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor10 / 68959145
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal263 / 336030778
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain273 / 1100989247
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine2 / 2344728
kidney12 / 21177756
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis13 / 33044239
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213849_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.05
Adipocyte11.15
AdrenalCortex12.4
Adrenalgland8.65
Amygdala245.4
Appendix17.3
AtrioventricularNode11.05
BDCA4+_DentriticCells10.4
Bonemarrow11.2
BronchialEpithelialCells10.15
CD105+_Endothelial14.05
CD14+_Monocytes11.15
CD19+_BCells(neg._sel.)11.2
CD33+_Myeloid15.6
CD34+12.5
CD4+_Tcells13.7
CD56+_NKCells118.15
CD71+_EarlyErythroid9.6
CD8+_Tcells15.3
CardiacMyocytes17.2
Caudatenucleus86.85
Cerebellum12.45
CerebellumPeduncles20.85
CiliaryGanglion13.2
CingulateCortex120.95
Colorectaladenocarcinoma10.8
DorsalRootGanglion23.55
FetalThyroid11.75
Fetalbrain167.8
Fetalliver10
Fetallung7.75
GlobusPallidus45.05
Heart14.65
Hypothalamus118.5
Kidney9.4
Leukemia_chronicMyelogenousK-5629.55
Leukemia_promyelocytic-HL-6010.05
Leukemialymphoblastic(MOLT-4)8.15
Liver15.1
Lung11.55
Lymphnode8.25
Lymphoma_burkitts(Daudi)13.85
Lymphoma_burkitts(Raji)15.55
MedullaOblongata70.15
OccipitalLobe76
OlfactoryBulb34.95
Ovary8
Pancreas9.2
PancreaticIslet24.5
ParietalLobe120.2
Pituitary26.65
Placenta8.5
Pons40.65
PrefrontalCortex147.95
Prostate13.35
Salivarygland9.65
SkeletalMuscle14.35
Skin11.75
SmoothMuscle11.85
Spinalcord80.85
SubthalamicNucleus65
SuperiorCervicalGanglion21.3
TemporalLobe45.5
Testis9.95
TestisGermCell8.65
TestisIntersitial10.05
TestisLeydigCell11.55
TestisSeminiferousTubule9.3
Thalamus89.85
Thymus8.45
Thyroid13.6
Tongue11.5
Tonsil11.85
Trachea8.85
TrigeminalGanglion15.9
Uterus8.45
UterusCorpus11.1
WholeBlood14.3
Wholebrain150.15
colon10.2
pineal_day288
pineal_night169.14
retina56.175
small_intestine11.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12880_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.12 ± 0.41
Basal Forebrain8.06 ± 0.05
Basal Part of Pons8.33 ± 0.19
Cerebellar Cortex7.34 ± 0.33
Cerebellar Nuclei7.83 ± 0.27
Claustrum8.45 ± 0.44
Epithalamus7.11 ± 0.85
Frontal Lobe7.79 ± 0.37
Globus Pallidus7.71 ± 0.4
Hypothalamus7.73 ± 0.33
Insula7.72 ± 0.34
Limbic Lobe8.02 ± 0.45
Mesencephalon7.85 ± 0.37
Myelencephalon7.84 ± 0.44
Occipital Lobe8.32 ± 0.47
Parietal Lobe7.91 ± 0.35
Pontine Tegmentum7.89 ± 0.44
Striatum8.7 ± 0.25
Subthalamus7.44 ± 0.34
Temporal Lobe7.78 ± 0.32
Thalamus7.81 ± 0.22
White Matter7.36 ± 0.72
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp2r2bCBCerebellum17.07
23.83
Ppp2r2bCTXCerebral cortex5.2
3.78
Ppp2r2bHIPHippocampal region11.01
6.07
Ppp2r2bHPFHippocampal formation12.01
9.15
Ppp2r2bHYHypothalamus4.66
2.99
Ppp2r2bLSXLateral septal complex0.81
0.47
Ppp2r2bMBMidbrain3.88
3.35
Ppp2r2bMYMedulla10.69
10.6
Ppp2r2bOLFOlfactory bulb18.14
11.61
Ppp2r2bPPons9.17
8.4
Ppp2r2bPALPallidum5.65
4.06
Ppp2r2bRHPRetrohippocampal region13.01
12.21
Ppp2r2bsAMYStriatum-like amygdalar nuclei2.53
1.3
Ppp2r2bSTRStriatum0.94
0.59
Ppp2r2bSTRdStriatum dorsal region0.41
0.29
Ppp2r2bSTRvStriatum ventral region1.98
1.17
Ppp2r2bTHThalamus1.78
1
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00068115 20 68 87 GEYNVYSTFQSHEPEFDYLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018