AutismKB 2.0

Annotation Detail for EXD2


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Basic Information Top
Gene Symbol:EXD2 ( C14orf114,DKFZp781A0133,DKFZp781L15100,EXDL2,FLJ10738 )
Gene Full Name: exonuclease 3'-5' domain containing 2
Band: 14q24.1
Quick LinksEntrez ID:55218; OMIM: NA; Uniprot ID:EXD2_HUMAN; ENSEMBL ID: ENSG00000081177; HGNC ID: 20217
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus32 / 56401256
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor17 / 26384564
glioma5 / 10688346
head and neck tumor10 / 13630273
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal167 / 336030749
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder2 / 2975767
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain78 / 110098970
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye7 / 21105433
heart1 / 8962611
intestine4 / 23447217
kidney13 / 21177761
larynx2 / 2414582
liver4 / 20774319
lung21 / 33697462
lymph1 / 4427022
lymph node2 / 9161021
mammary gland4 / 15327126
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas11 / 21481251
parathyroid6 / 20539292
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta7 / 28082524
prostate7 / 18934536
salivary gland1 / 2015549
skin5 / 21057423
spleen0 / 539520 
stomach3 / 9661931
testis56 / 330442169
thymus4 / 8113149
thyroid2 / 4747342
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218363_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.95
Adipocyte15.1
AdrenalCortex15.4
Adrenalgland23.25
Amygdala24.6
Appendix20.2
AtrioventricularNode12.55
BDCA4+_DentriticCells12.65
Bonemarrow13.8
BronchialEpithelialCells19.25
CD105+_Endothelial10.7
CD14+_Monocytes8.15
CD19+_BCells(neg._sel.)7.8
CD33+_Myeloid14.5
CD34+16.65
CD4+_Tcells9.25
CD56+_NKCells13.1
CD71+_EarlyErythroid4.65
CD8+_Tcells10.35
CardiacMyocytes14
Caudatenucleus23.55
Cerebellum30.9
CerebellumPeduncles18.45
CiliaryGanglion10.45
CingulateCortex18
Colorectaladenocarcinoma13.9
DorsalRootGanglion13.85
FetalThyroid13.85
Fetalbrain28.45
Fetalliver13.8
Fetallung13.15
GlobusPallidus12.7
Heart16.65
Hypothalamus27.35
Kidney14.75
Leukemia_chronicMyelogenousK-56213
Leukemia_promyelocytic-HL-6010.3
Leukemialymphoblastic(MOLT-4)9.35
Liver16.7
Lung16.8
Lymphnode13.2
Lymphoma_burkitts(Daudi)18.8
Lymphoma_burkitts(Raji)17.55
MedullaOblongata17.35
OccipitalLobe24.9
OlfactoryBulb14.55
Ovary9.05
Pancreas10.9
PancreaticIslet19.8
ParietalLobe16.2
Pituitary32.05
Placenta12.75
Pons16.9
PrefrontalCortex24.1
Prostate16.6
Salivarygland17.25
SkeletalMuscle17.5
Skin11.75
SmoothMuscle14.5
Spinalcord19.75
SubthalamicNucleus12.35
SuperiorCervicalGanglion18.8
TemporalLobe14.2
Testis76.75
TestisGermCell48.6
TestisIntersitial21.15
TestisLeydigCell24.55
TestisSeminiferousTubule31.1
Thalamus14.1
Thymus13
Thyroid19.5
Tongue14.5
Tonsil13.2
Trachea24.85
TrigeminalGanglion13.95
Uterus11.5
UterusCorpus21.45
WholeBlood14.3
Wholebrain21.35
colon18.55
pineal_day30.16
pineal_night31.24
retina20.4
small_intestine24.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P205293
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.69 ± 0.29
Basal Forebrain5.69 ± 0.31
Basal Part of Pons5.61 ± 0.36
Cerebellar Cortex5.4 ± 0.24
Cerebellar Nuclei5.29 ± 0.47
Claustrum5.99 ± 0.38
Epithalamus5.66 ± 0.13
Frontal Lobe5.54 ± 0.34
Globus Pallidus6.11 ± 0.27
Hypothalamus5.5 ± 0.51
Insula5.73 ± 0.17
Limbic Lobe5.75 ± 0.33
Mesencephalon5.67 ± 0.42
Myelencephalon5.68 ± 0.38
Occipital Lobe5.92 ± 0.39
Parietal Lobe5.74 ± 0.41
Pontine Tegmentum5.63 ± 0.35
Striatum5.82 ± 0.29
Subthalamus5.4 ± 0.23
Temporal Lobe5.64 ± 0.35
Thalamus5.67 ± 0.31
White Matter6.67 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Exdl2CBCerebellum42.86
63.69
Exdl2CTXCerebral cortex100
100
Exdl2HIPHippocampal region100
100
Exdl2HPFHippocampal formation100
100
Exdl2HYHypothalamus69.91
52.6
Exdl2LSXLateral septal complex69.48
45.95
Exdl2MBMidbrain78.25
67.83
Exdl2MYMedulla62.91
58.3
Exdl2OLFOlfactory bulb100
100
Exdl2PPons60.37
53.03
Exdl2PALPallidum68.53
58.17
Exdl2RHPRetrohippocampal region100
100
Exdl2sAMYStriatum-like amygdalar nuclei100
100
Exdl2STRStriatum100
87.03
Exdl2STRdStriatum dorsal region100
88.71
Exdl2STRvStriatum ventral region100
82.13
Exdl2THThalamus100
99.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EXD2_HUMAN_197 12 197 208 MDGMVPGNHQGR PRIDE
PAp00035692 17 175 191 LGEEVNGEATESQQKPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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