Annotation Detail for ASXL2
Basic Information Top
| Gene Symbol: | ASXL2 ( ASXH2,DKFZp686C1968,FLJ10898,KIAA1685 ) |
|---|---|
| Gene Full Name: | additional sex combs like 2 (Drosophila) |
| Band: | 2p23.3 |
| Quick Links | Entrez ID:55252; OMIM: 612991; Uniprot ID:ASXL2_HUMAN; ENSEMBL ID: ENSG00000143970; HGNC ID: 23805 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.119815
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 3 / 70761 | 42 |  |
| blastocyst | 2 / 62319 | 32 | |
| fetus | 26 / 564012 | 46 | |
| neonate | 0 / 31097 | 0 | |
| infant | 1 / 23620 | 42 | |
| juvenile | 5 / 55556 | 89 |  |
| adult | 101 / 1939121 | 52 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 4 / 82823 | 48 | |
| colorectal tumor | 7 / 114246 | 61 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 11 / 263845 | 41 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 15 / 136302 | 110 | |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 9 / 96359 | 93 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 5 / 97250 | 51 | |
| normal | 117 / 3360307 | 34 | |
| ovarian tumor | 4 / 76682 | 52 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 5 / 125191 | 39 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 1 / 29757 | 33 | |
| blood | 0 / 123478 | 0 | |
| bone | 5 / 71655 | 69 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 16 / 1100989 | 14 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 1 / 149255 | 6 |  |
| ear | 2 / 16212 | 123 | |
| embryonic tissue | 12 / 215722 | 55 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 10 / 211054 | 47 | |
| heart | 4 / 89626 | 44 | |
| intestine | 14 / 234472 | 59 | |
| kidney | 9 / 211777 | 42 | |
| larynx | 1 / 24145 | 41 | |
| liver | 12 / 207743 | 57 | |
| lung | 9 / 336974 | 26 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 5 / 91610 | 54 | |
| mammary gland | 11 / 153271 | 71 | |
| mouth | 11 / 67052 | 164 | |
| muscle | 5 / 107715 | 46 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 4 / 102051 | 39 | |
| pancreas | 11 / 214812 | 51 | |
| parathyroid | 2 / 20539 | 97 | |
| pharynx | 2 / 41328 | 48 | |
| pituitary gland | 3 / 16585 | 180 | |
| placenta | 10 / 280825 | 35 | |
| prostate | 3 / 189345 | 15 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 5 / 210574 | 23 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 2 / 96619 | 20 | |
| testis | 19 / 330442 | 57 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 2 / 47473 | 42 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 13 / 232878 | 55 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 218659_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 77.75 | |
| Adipocyte | 36.65 | |
| AdrenalCortex | 50.95 | |
| Adrenalgland | 52.45 | |
| Amygdala | 43.05 | |
| Appendix | 65.75 | |
| AtrioventricularNode | 40.3 | |
| BDCA4+_DentriticCells | 109.35 | |
| Bonemarrow | 93.3 | |
| BronchialEpithelialCells | 52.55 | |
| CD105+_Endothelial | 117 | |
| CD14+_Monocytes | 81.55 | |
| CD19+_BCells(neg._sel.) | 61.85 | |
| CD33+_Myeloid | 168.85 | |
| CD34+ | 113.05 | |
| CD4+_Tcells | 220.15 |  |
| CD56+_NKCells | 66.15 | |
| CD71+_EarlyErythroid | 60.2 | |
| CD8+_Tcells | 175.15 | |
| CardiacMyocytes | 33.85 | |
| Caudatenucleus | 25.35 | |
| Cerebellum | 48.7 | |
| CerebellumPeduncles | 50.8 | |
| CiliaryGanglion | 42.75 | |
| CingulateCortex | 43.25 | |
| Colorectaladenocarcinoma | 62.9 | |
| DorsalRootGanglion | 50.1 | |
| FetalThyroid | 63.65 | |
| Fetalbrain | 31.65 | |
| Fetalliver | 91.2 | |
| Fetallung | 41.85 | |
| GlobusPallidus | 42.35 | |
| Heart | 39.9 | |
| Hypothalamus | 33.5 | |
| Kidney | 50.95 | |
| Leukemia_chronicMyelogenousK-562 | 47.55 | |
| Leukemia_promyelocytic-HL-60 | 61.15 | |
| Leukemialymphoblastic(MOLT-4) | 70.2 | |
| Liver | 45.65 | |
| Lung | 63.15 | |
| Lymphnode | 59.45 | |
| Lymphoma_burkitts(Daudi) | 64.2 | |
| Lymphoma_burkitts(Raji) | 85.5 | |
| MedullaOblongata | 44 | |
| OccipitalLobe | 43.5 | |
| OlfactoryBulb | 57.65 | |
| Ovary | 32.25 | |
| Pancreas | 33.7 | |
| PancreaticIslet | 60.7 | |
| ParietalLobe | 52.9 | |
| Pituitary | 171.05 | |
| Placenta | 60.15 | |
| Pons | 49.85 | |
| PrefrontalCortex | 84.15 | |
| Prostate | 109.9 | |
| Salivarygland | 104.45 | |
| SkeletalMuscle | 57.45 | |
| Skin | 57 | |
| SmoothMuscle | 53.8 | |
| Spinalcord | 38.45 | |
| SubthalamicNucleus | 50.9 | |
| SuperiorCervicalGanglion | 85.55 | |
| TemporalLobe | 45.3 | |
| Testis | 61.45 | |
| TestisGermCell | 93.9 | |
| TestisIntersitial | 91.25 | |
| TestisLeydigCell | 74.45 | |
| TestisSeminiferousTubule | 86.3 | |
| Thalamus | 40.3 | |
| Thymus | 124.15 | |
| Thyroid | 58.05 | |
| Tongue | 54.75 | |
| Tonsil | 71.85 | |
| Trachea | 57 | |
| TrigeminalGanglion | 73.7 | |
| Uterus | 74.15 | |
| UterusCorpus | 54.9 | |
| WholeBlood | 700.45 | |
| Wholebrain | 49.9 | |
| colon | 81.9 | |
| pineal_day | 114.46 | |
| pineal_night | 86.9 | |
| retina | 101.375 | |
| small_intestine | 49.4 | |
- Probe name: CUST_507_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.91 ± 0.3 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.94 ± 0.27 | |
| Basal Part of Pons | 4.52 ± 0.54 | |
| Cerebellar Cortex | 4.91 ± 0.32 | |
| Cerebellar Nuclei | 4.54 ± 0.32 | |
| Claustrum | 4.85 ± 0.59 | |
| Epithalamus | 4.94 ± 0.54 | |
| Frontal Lobe | 4.59 ± 0.44 | |
| Globus Pallidus | 5.27 ± 0.26 | |
| Hypothalamus | 4.39 ± 0.53 | |
| Insula | 4.69 ± 0.6 | |
| Limbic Lobe | 4.85 ± 0.48 | |
| Mesencephalon | 4.72 ± 0.55 | |
| Myelencephalon | 4.72 ± 0.49 | |
| Occipital Lobe | 4.86 ± 0.54 | |
| Parietal Lobe | 4.69 ± 0.55 | |
| Pontine Tegmentum | 4.68 ± 0.55 | |
| Striatum | 4.92 ± 0.56 | |
| Subthalamus | 4.57 ± 0.35 | |
| Temporal Lobe | 4.56 ± 0.42 | |
| Thalamus | 4.55 ± 0.49 | |
| White Matter | 5.59 ± 0.39 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Asxl2 | CB | Cerebellum | 36.72 | |
| 43.71 | | |||
| Asxl2 | CTX | Cerebral cortex | 50.29 | |
| 34.93 | | |||
| Asxl2 | HIP | Hippocampal region | 37.24 | |
| 42.49 | | |||
| Asxl2 | HPF | Hippocampal formation | 39.33 | |
| 37.36 | | |||
| Asxl2 | HY | Hypothalamus | 17.52 | |
| 13.36 | | |||
| Asxl2 | LSX | Lateral septal complex | 19.05 | |
| 12.87 | | |||
| Asxl2 | MB | Midbrain | 25.42 | |
| 20.6 | | |||
| Asxl2 | MY | Medulla | 42.13 | |
| 39.49 | | |||
| Asxl2 | OLF | Olfactory bulb | 46.33 | |
| 35.49 | | |||
| Asxl2 | P | Pons | 31.2 | |
| 27.7 | | |||
| Asxl2 | PAL | Pallidum | 30.39 | |
| 25.44 | | |||
| Asxl2 | RHP | Retrohippocampal region | 41.5 | |
| 31.05 | | |||
| Asxl2 | sAMY | Striatum-like amygdalar nuclei | 25.54 | |
| 17.4 | | |||
| Asxl2 | STR | Striatum | 43.62 | |
| 30.82 | | |||
| Asxl2 | STRd | Striatum dorsal region | 45.35 | |
| 32.61 | | |||
| Asxl2 | STRv | Striatum ventral region | 57.28 | |
| 38.34 | | |||
| Asxl2 | TH | Thalamus | 34.87 | |
| 27.86 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00009335 | 18 | 811 | 828 | ATATVASVSHPQGPSSCR | Peptide Atlas |