AutismKB 2.0

Annotation Detail for ADI1


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Basic Information Top
Gene Symbol:ADI1 ( APL1,ARD,FLJ10913,MTCBP1,SIPL )
Gene Full Name: acireductone dioxygenase 1
Band: 2p25.3
Quick LinksEntrez ID:55256; OMIM: 613400; Uniprot ID:MTND_HUMAN; ENSEMBL ID: ENSG00000182551; HGNC ID: 30576
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst5 / 6231980
fetus33 / 56401258
neonate0 / 310970 
infant3 / 23620127
juvenile2 / 5555635
adult247 / 1939121127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor6 / 34366174
chondrosarcoma16 / 82823193
colorectal tumor15 / 114246131
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor17 / 26384564
glioma10 / 10688393
head and neck tumor4 / 13630229
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor14 / 96359145
lung tumor14 / 103127135
lymphoma5 / 7175569
non-neoplasia10 / 97250102
normal311 / 336030792
ovarian tumor8 / 76682104
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer30 / 102680292
retinoblastoma3 / 4635664
skin tumor17 / 124949136
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites6 / 40015149
bladder1 / 2975733
blood10 / 12347880
bone18 / 71655251
bone marrow2 / 4880140
brain60 / 110098954
cervix10 / 48171207
connective tissue10 / 14925566
ear3 / 16212185
embryonic tissue18 / 21572283
esophagus2 / 2020998
eye26 / 211054123
heart11 / 89626122
intestine28 / 234472119
kidney23 / 211777108
larynx2 / 2414582
liver38 / 207743182
lung42 / 336974124
lymph3 / 4427067
lymph node9 / 9161098
mammary gland9 / 15327158
mouth0 / 670520 
muscle7 / 10771564
nerve4 / 15768253
ovary9 / 10205188
pancreas17 / 21481279
parathyroid5 / 20539243
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta58 / 280825206
prostate37 / 189345195
salivary gland2 / 2015599
skin20 / 21057494
spleen2 / 5395237
stomach5 / 9661951
testis11 / 33044233
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus38 / 232878163
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217761_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.8
Adipocyte151.8
AdrenalCortex71.75
Adrenalgland382.3
Amygdala116.9
Appendix23.05
AtrioventricularNode16.6
BDCA4+_DentriticCells445.7
Bonemarrow93.05
BronchialEpithelialCells132.65
CD105+_Endothelial156.2
CD14+_Monocytes214.65
CD19+_BCells(neg._sel.)298.35
CD33+_Myeloid350.05
CD34+184.65
CD4+_Tcells71.6
CD56+_NKCells173.25
CD71+_EarlyErythroid30.95
CD8+_Tcells28.95
CardiacMyocytes47.6
Caudatenucleus69.7
Cerebellum20.2
CerebellumPeduncles10.35
CiliaryGanglion13.85
CingulateCortex18.05
Colorectaladenocarcinoma116.15
DorsalRootGanglion37.15
FetalThyroid65.15
Fetalbrain20.35
Fetalliver165.05
Fetallung106.9
GlobusPallidus9
Heart274.4
Hypothalamus108.75
Kidney761.05
Leukemia_chronicMyelogenousK-56217.2
Leukemia_promyelocytic-HL-6054.3
Leukemialymphoblastic(MOLT-4)19.2
Liver3579.6
Lung819.1
Lymphnode61.75
Lymphoma_burkitts(Daudi)15.1
Lymphoma_burkitts(Raji)29.85
MedullaOblongata26.5
OccipitalLobe36.15
OlfactoryBulb142.6
Ovary11.35
Pancreas49.3
PancreaticIslet20.95
ParietalLobe14.3
Pituitary104.1
Placenta321.6
Pons16.9
PrefrontalCortex51.05
Prostate1634.4
Salivarygland89
SkeletalMuscle16.2
Skin21.55
SmoothMuscle83.95
Spinalcord148.7
SubthalamicNucleus27.65
SuperiorCervicalGanglion28.05
TemporalLobe29.15
Testis122.6
TestisGermCell63.95
TestisIntersitial14.9
TestisLeydigCell17.7
TestisSeminiferousTubule14.35
Thalamus47.55
Thymus82.75
Thyroid495.3
Tongue47.55
Tonsil20.95
Trachea136.75
TrigeminalGanglion21.15
Uterus143.65
UterusCorpus14.75
WholeBlood133.25
Wholebrain89.75
colon462.4
pineal_day32.26
pineal_night45.08
retina255.35
small_intestine480.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P148194
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.58 ± 0.28
Basal Forebrain8.87 ± 0.15
Basal Part of Pons8.41 ± 0.3
Cerebellar Cortex8.35 ± 0.1
Cerebellar Nuclei9.04 ± 0.34
Claustrum8.41 ± 0.23
Epithalamus8.65 ± 0.18
Frontal Lobe8.65 ± 0.26
Globus Pallidus9.58 ± 0.22
Hypothalamus8.68 ± 0.33
Insula8.58 ± 0.23
Limbic Lobe8.51 ± 0.35
Mesencephalon8.85 ± 0.39
Myelencephalon8.7 ± 0.32
Occipital Lobe8.44 ± 0.3
Parietal Lobe8.62 ± 0.31
Pontine Tegmentum8.73 ± 0.26
Striatum9.12 ± 0.36
Subthalamus8.75 ± 0.13
Temporal Lobe8.6 ± 0.25
Thalamus8.78 ± 0.24
White Matter9.87 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adi1CBCerebellum7.48
8.39
Adi1CTXCerebral cortex2.35
2.1
Adi1HIPHippocampal region5.6
5.55
Adi1HPFHippocampal formation6.35
5.84
Adi1HYHypothalamus14.09
13.87
Adi1LSXLateral septal complex3.03
2.51
Adi1MBMidbrain2.48
3.48
Adi1MYMedulla12.72
14.55
Adi1OLFOlfactory bulb9.71
8.66
Adi1PPons11.59
12.09
Adi1PALPallidum8.04
7.36
Adi1RHPRetrohippocampal region8.59
7
Adi1sAMYStriatum-like amygdalar nuclei14.61
9.49
Adi1STRStriatum7.18
5.32
Adi1STRdStriatum dorsal region3.28
2.51
Adi1STRvStriatum ventral region18.88
13.04
Adi1THThalamus5.08
4.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MTND_HUMAN_59 12 59 70 NYSWMDIITICK PRIDE
MTND_HUMAN_96 12 96 107 YILDGSGYFDVR PRIDE
PAp00429184 14 83 96 MFYEEHLHLDDEIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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