AutismKB 2.0

Annotation Detail for TMEM143


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Basic Information Top
Gene Symbol:TMEM143 ( FLJ10922 )
Gene Full Name: transmembrane protein 143
Band: 19q13.32
Quick LinksEntrez ID:55260; OMIM: NA; Uniprot ID:TM143_HUMAN; ENSEMBL ID: ENSG00000161558; HGNC ID: 25603
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus26 / 56401246
neonate1 / 3109732
infant1 / 2362042
juvenile4 / 5555671
adult33 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor5 / 34366145
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor5 / 11936941
germ cell tumor7 / 26384526
glioma6 / 10688356
head and neck tumor0 / 1363020 
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor7 / 9635972
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal169 / 336030750
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow2 / 4880140
brain80 / 110098972
cervix5 / 48171103
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus3 / 20209148
eye5 / 21105423
heart31 / 89626345
intestine10 / 23447242
kidney21 / 21177799
larynx0 / 241450 
liver9 / 20774343
lung6 / 33697417
lymph1 / 4427022
lymph node0 / 916100 
mammary gland3 / 15327119
mouth4 / 6705259
muscle4 / 10771537
nerve0 / 157680 
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate6 / 18934531
salivary gland0 / 201550 
skin3 / 21057414
spleen7 / 53952129
stomach2 / 9661920
testis3 / 3304429
thymus18 / 81131221
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219589_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.4
Adipocyte5.5
AdrenalCortex6.8
Adrenalgland4.75
Amygdala5.55
Appendix6.1
AtrioventricularNode5.3
BDCA4+_DentriticCells5.65
Bonemarrow5.7
BronchialEpithelialCells5.4
CD105+_Endothelial5.7
CD14+_Monocytes6
CD19+_BCells(neg._sel.)6.05
CD33+_Myeloid10
CD34+7.1
CD4+_Tcells5.9
CD56+_NKCells6.6
CD71+_EarlyErythroid5.5
CD8+_Tcells5.5
CardiacMyocytes7.8
Caudatenucleus5
Cerebellum4.6
CerebellumPeduncles6.4
CiliaryGanglion4.4
CingulateCortex5.9
Colorectaladenocarcinoma5.65
DorsalRootGanglion5.05
FetalThyroid5.65
Fetalbrain5.4
Fetalliver4.95
Fetallung4.3
GlobusPallidus4.5
Heart8.1
Hypothalamus5.85
Kidney4.65
Leukemia_chronicMyelogenousK-5625.05
Leukemia_promyelocytic-HL-604.95
Leukemialymphoblastic(MOLT-4)4.4
Liver8.05
Lung6.05
Lymphnode4.6
Lymphoma_burkitts(Daudi)7.25
Lymphoma_burkitts(Raji)8.05
MedullaOblongata5.1
OccipitalLobe4.95
OlfactoryBulb4.4
Ovary4
Pancreas4.7
PancreaticIslet6.05
ParietalLobe6
Pituitary6.45
Placenta5.6
Pons5.65
PrefrontalCortex6.75
Prostate6.45
Salivarygland4.7
SkeletalMuscle6.85
Skin5.5
SmoothMuscle6.3
Spinalcord5.9
SubthalamicNucleus5.25
SuperiorCervicalGanglion7.5
TemporalLobe5.35
Testis4.75
TestisGermCell4.65
TestisIntersitial4.9
TestisLeydigCell6.7
TestisSeminiferousTubule4.8
Thalamus5.75
Thymus4.35
Thyroid6.7
Tongue6.4
Tonsil5.7
Trachea4.65
TrigeminalGanglion6.95
Uterus4.65
UterusCorpus5.8
WholeBlood6.05
Wholebrain4.4
colon5.55
pineal_day6.88
pineal_night6.72
retina6.8
small_intestine5.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_592_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.55 ± 1.22
Basal Forebrain1.77 ± 0.2
Basal Part of Pons1.63 ± 0.51
Cerebellar Cortex1.68 ± 0.75
Cerebellar Nuclei2.06 ± 0.73
Claustrum2.67 ± 0.95
Epithalamus1.52 ± 0.74
Frontal Lobe1.68 ± 0.67
Globus Pallidus2.38 ± 0.38
Hypothalamus1.92 ± 0.73
Insula1.55 ± 0.42
Limbic Lobe1.82 ± 0.62
Mesencephalon1.99 ± 0.73
Myelencephalon1.89 ± 0.71
Occipital Lobe1.85 ± 0.63
Parietal Lobe1.95 ± 0.8
Pontine Tegmentum1.84 ± 0.68
Striatum2.03 ± 0.55
Subthalamus1.94 ± 0.62
Temporal Lobe1.75 ± 0.75
Thalamus1.75 ± 0.57
White Matter2.29 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem143CBCerebellum17.78
21.51
Tmem143CTXCerebral cortex39.27
30.54
Tmem143HIPHippocampal region28.48
30.04
Tmem143HPFHippocampal formation28.82
27.46
Tmem143HYHypothalamus14.97
12.24
Tmem143LSXLateral septal complex3.48
2.34
Tmem143MBMidbrain17.87
17.34
Tmem143MYMedulla31.63
39.27
Tmem143OLFOlfactory bulb63.39
53.48
Tmem143PPons32.17
38.19
Tmem143PALPallidum22.59
21.94
Tmem143RHPRetrohippocampal region30.05
23.86
Tmem143sAMYStriatum-like amygdalar nuclei44.94
36.21
Tmem143STRStriatum31.83
23.81
Tmem143STRdStriatum dorsal region31.7
22.73
Tmem143STRvStriatum ventral region43.88
33.54
Tmem143THThalamus19.84
16.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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