AutismKB 2.0

Annotation Detail for PPP2R5D


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Basic Information Top
Gene Symbol:PPP2R5D ( B56D,MGC2134,MGC8949 )
Gene Full Name: protein phosphatase 2, regulatory subunit B', delta
Band: 6p21.1
Quick LinksEntrez ID:5528; OMIM: 601646; Uniprot ID:2A5D_HUMAN; ENSEMBL ID: ENSG00000112640; HGNC ID: 9312
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst8 / 62319128
fetus34 / 56401260
neonate3 / 3109796
infant2 / 2362084
juvenile6 / 55556107
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor3 / 3436687
chondrosarcoma12 / 82823144
colorectal tumor5 / 11424643
esophageal tumor2 / 17290115
gastrointestinal tumor11 / 11936992
germ cell tumor24 / 26384590
glioma11 / 106883102
head and neck tumor20 / 136302146
kidney tumor11 / 68959159
leukemia4 / 9584241
liver tumor12 / 96359124
lung tumor14 / 103127135
lymphoma21 / 71755292
non-neoplasia6 / 9725061
normal243 / 336030772
ovarian tumor3 / 7668239
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer10 / 10268097
retinoblastoma13 / 46356280
skin tumor30 / 124949240
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites5 / 40015124
bladder1 / 2975733
blood9 / 12347872
bone4 / 7165555
bone marrow1 / 4880120
brain137 / 1100989124
cervix8 / 48171166
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus2 / 2020998
eye19 / 21105490
heart3 / 8962633
intestine13 / 23447255
kidney13 / 21177761
larynx0 / 241450 
liver17 / 20774381
lung30 / 33697489
lymph21 / 44270474
lymph node2 / 9161021
mammary gland10 / 15327165
mouth9 / 67052134
muscle4 / 10771537
nerve0 / 157680 
ovary11 / 102051107
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta10 / 28082535
prostate15 / 18934579
salivary gland3 / 20155148
skin36 / 210574170
spleen6 / 53952111
stomach5 / 9661951
testis29 / 33044287
thymus35 / 81131431
thyroid7 / 47473147
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord0 / 136800 
uterus27 / 232878115
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211159_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts106.6
Adipocyte80.1
AdrenalCortex89.85
Adrenalgland67
Amygdala117.75
Appendix82.3
AtrioventricularNode49.25
BDCA4+_DentriticCells93.95
Bonemarrow104.45
BronchialEpithelialCells80.7
CD105+_Endothelial82.5
CD14+_Monocytes74.8
CD19+_BCells(neg._sel.)98.05
CD33+_Myeloid99.85
CD34+116.8
CD4+_Tcells129.25
CD56+_NKCells123
CD71+_EarlyErythroid76.85
CD8+_Tcells101
CardiacMyocytes206.55
Caudatenucleus76.05
Cerebellum129.55
CerebellumPeduncles154.85
CiliaryGanglion60.55
CingulateCortex97.5
Colorectaladenocarcinoma127.9
DorsalRootGanglion67
FetalThyroid75.2
Fetalbrain100.05
Fetalliver96.35
Fetallung54.6
GlobusPallidus61.4
Heart302
Hypothalamus92.25
Kidney79.45
Leukemia_chronicMyelogenousK-56286.4
Leukemia_promyelocytic-HL-6077.25
Leukemialymphoblastic(MOLT-4)134.8
Liver215.25
Lung123.9
Lymphnode68.65
Lymphoma_burkitts(Daudi)131.8
Lymphoma_burkitts(Raji)152.5
MedullaOblongata74.2
OccipitalLobe73.55
OlfactoryBulb62.2
Ovary57.55
Pancreas73.45
PancreaticIslet112.8
ParietalLobe110.8
Pituitary100.95
Placenta48.4
Pons85.3
PrefrontalCortex108.3
Prostate150.8
Salivarygland65.65
SkeletalMuscle176.7
Skin63.15
SmoothMuscle103.85
Spinalcord88.95
SubthalamicNucleus84.65
SuperiorCervicalGanglion97.85
TemporalLobe75.7
Testis122.9
TestisGermCell66.1
TestisIntersitial63.85
TestisLeydigCell81.05
TestisSeminiferousTubule63.35
Thalamus74.65
Thymus116.6
Thyroid120.95
Tongue79.25
Tonsil110.35
Trachea106.9
TrigeminalGanglion84.7
Uterus66.55
UterusCorpus75.75
WholeBlood93.7
Wholebrain111.6
colon91.2
pineal_day96.1
pineal_night93.98
retina124.4
small_intestine92
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6876_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.48 ± 0.35
Basal Forebrain7.25 ± 0.2
Basal Part of Pons7.67 ± 0.35
Cerebellar Cortex7.27 ± 0.24
Cerebellar Nuclei7.11 ± 0.37
Claustrum7.89 ± 0.41
Epithalamus6.63 ± 0.49
Frontal Lobe7.26 ± 0.36
Globus Pallidus6.91 ± 0.17
Hypothalamus6.97 ± 0.5
Insula7.3 ± 0.37
Limbic Lobe7.52 ± 0.36
Mesencephalon7.4 ± 0.49
Myelencephalon7.31 ± 0.43
Occipital Lobe7.59 ± 0.39
Parietal Lobe7.4 ± 0.34
Pontine Tegmentum7.25 ± 0.28
Striatum7.79 ± 0.39
Subthalamus7.27 ± 0.18
Temporal Lobe7.28 ± 0.34
Thalamus7.46 ± 0.36
White Matter6.34 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp2r5dCBCerebellum71.23
96.49
Ppp2r5dCTXCerebral cortex78.18
70.08
Ppp2r5dHIPHippocampal region56.58
93.59
Ppp2r5dHPFHippocampal formation62.42
83.85
Ppp2r5dHYHypothalamus39.23
39.9
Ppp2r5dLSXLateral septal complex39.95
36.29
Ppp2r5dMBMidbrain40.49
41.92
Ppp2r5dMYMedulla58.32
77.27
Ppp2r5dOLFOlfactory bulb70.83
71.65
Ppp2r5dPPons41.2
49.71
Ppp2r5dPALPallidum37.02
38.77
Ppp2r5dRHPRetrohippocampal region71.58
70.2
Ppp2r5dsAMYStriatum-like amygdalar nuclei62.95
56.99
Ppp2r5dSTRStriatum100
97.32
Ppp2r5dSTRdStriatum dorsal region100
100
Ppp2r5dSTRvStriatum ventral region100
99.8
Ppp2r5dTHThalamus91.39
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
2A5D_HUMAN_279 8 279 286 QINHIFYR PRIDE
2A5D_HUMAN_442 11 442 452 VLPIMFPALYR PRIDE
2A5D_HUMAN_591 12 591 602 AEEFLTASQEAL PRIDE
PAp00009749 12 378 389 CVSSPHFQVAER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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