AutismKB 2.0

Annotation Detail for BOLA2


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Basic Information Top
Gene Symbol:BOLA2 ( BOLA2A,My016 )
Gene Full Name: bolA homolog 2 (E. coli)
Band: 16p11.2
Quick LinksEntrez ID:552900; OMIM: 613182; Uniprot ID:BOLA2_HUMAN; ENSEMBL ID: ENSG00000183336; HGNC ID: 29488
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst7 / 62319112
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult100 / 193912151
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor18 / 26384568
glioma7 / 10688365
head and neck tumor6 / 13630244
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor2 / 9635920
lung tumor5 / 10312748
lymphoma8 / 71755111
non-neoplasia3 / 9725030
normal168 / 336030749
ovarian tumor4 / 7668252
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer11 / 102680107
retinoblastoma4 / 4635686
skin tumor29 / 124949232
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal63 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites4 / 4001599
bladder4 / 29757134
blood3 / 12347824
bone3 / 7165541
bone marrow4 / 4880181
brain57 / 110098951
cervix1 / 4817120
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue22 / 215722101
esophagus0 / 202090 
eye10 / 21105447
heart8 / 8962689
intestine10 / 23447242
kidney12 / 21177756
larynx1 / 2414541
liver14 / 20774367
lung21 / 33697462
lymph8 / 44270180
lymph node3 / 9161032
mammary gland9 / 15327158
mouth4 / 6705259
muscle4 / 10771537
nerve0 / 157680 
ovary5 / 10205148
pancreas4 / 21481218
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta21 / 28082574
prostate20 / 189345105
salivary gland2 / 2015599
skin34 / 210574161
spleen3 / 5395255
stomach4 / 9661941
testis11 / 33044233
thymus2 / 8113124
thyroid0 / 474730 
tonsil3 / 16999176
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular3 / 5178057
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood6 / 12347848
bone1 / 7165513
bone marrow1 / 4880120
brain16 / 110098914
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine9 / 23447238
kidney3 / 21177714
larynx2 / 2414582
liver3 / 20774314
lung1 / 3369742
lymph0 / 442700 
lymph node2 / 9161021
mammary gland6 / 15327139
mouth3 / 6705244
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate2 / 18934510
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach2 / 9661920
testis4 / 33044212
thymus8 / 8113198
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus7 / 23287830
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209836_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts207.1
Adipocyte12.75
AdrenalCortex15.7
Adrenalgland11.5
Amygdala9.6
Appendix11.2
AtrioventricularNode5.35
BDCA4+_DentriticCells89.35
Bonemarrow13.95
BronchialEpithelialCells94.3
CD105+_Endothelial97.9
CD14+_Monocytes74.15
CD19+_BCells(neg._sel.)142.8
CD33+_Myeloid37.35
CD34+79.35
CD4+_Tcells57.3
CD56+_NKCells76.35
CD71+_EarlyErythroid80.7
CD8+_Tcells62.25
CardiacMyocytes40.4
Caudatenucleus10.3
Cerebellum5.5
CerebellumPeduncles12.05
CiliaryGanglion4
CingulateCortex12.45
Colorectaladenocarcinoma33
DorsalRootGanglion6.95
FetalThyroid13.9
Fetalbrain10.75
Fetalliver13.25
Fetallung12.45
GlobusPallidus6.55
Heart20.15
Hypothalamus15.8
Kidney11.45
Leukemia_chronicMyelogenousK-56249.55
Leukemia_promyelocytic-HL-6094.85
Leukemialymphoblastic(MOLT-4)31.45
Liver11.9
Lung28.95
Lymphnode19.65
Lymphoma_burkitts(Daudi)102.7
Lymphoma_burkitts(Raji)93.8
MedullaOblongata10.25
OccipitalLobe8.25
OlfactoryBulb10.6
Ovary5.8
Pancreas18.65
PancreaticIslet20.25
ParietalLobe14.15
Pituitary13.95
Placenta13.05
Pons8.35
PrefrontalCortex14.8
Prostate13.55
Salivarygland12.1
SkeletalMuscle8.65
Skin5.35
SmoothMuscle49.75
Spinalcord14.85
SubthalamicNucleus7.65
SuperiorCervicalGanglion7.9
TemporalLobe12.75
Testis20.15
TestisGermCell18.45
TestisIntersitial28.6
TestisLeydigCell16.7
TestisSeminiferousTubule24.45
Thalamus21.8
Thymus21.2
Thyroid10.2
Tongue14.85
Tonsil23.2
Trachea7.4
TrigeminalGanglion6.9
Uterus7.55
UterusCorpus9.8
WholeBlood22.4
Wholebrain14.3
colon23.25
pineal_day17.82
pineal_night17.94
retina12.75
small_intestine26.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7590_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.83 ± 0.78
Basal Forebrain5.29 ± 0.25
Basal Part of Pons5.74 ± 0.47
Cerebellar Cortex4.89 ± 0.39
Cerebellar Nuclei5.12 ± 0.56
Claustrum4.72 ± 0.9
Epithalamus5.01 ± 0.42
Frontal Lobe5.49 ± 0.49
Globus Pallidus5.77 ± 0.5
Hypothalamus5.5 ± 0.48
Insula5.31 ± 0.39
Limbic Lobe5.22 ± 0.63
Mesencephalon5.31 ± 0.56
Myelencephalon5.28 ± 0.56
Occipital Lobe4.68 ± 0.65
Parietal Lobe5.21 ± 0.47
Pontine Tegmentum5.2 ± 0.5
Striatum5.36 ± 0.51
Subthalamus5.34 ± 0.66
Temporal Lobe5.42 ± 0.48
Thalamus5.27 ± 0.47
White Matter5.95 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bola2CBCerebellum0.6
0.96
Bola2CTXCerebral cortex0.37
0.69
Bola2HIPHippocampal region0.31
0.45
Bola2HPFHippocampal formation0.24
0.34
Bola2HYHypothalamus1.73
4.03
Bola2LSXLateral septal complex0.6
0.71
Bola2MBMidbrain0.23
0.38
Bola2MYMedulla0.29
0.28
Bola2OLFOlfactory bulb1.62
3.76
Bola2PPons0.4
0.75
Bola2PALPallidum0.18
0.21
Bola2RHPRetrohippocampal region0.14
0.2
Bola2sAMYStriatum-like amygdalar nuclei0.27
0.26
Bola2STRStriatum0.21
0.21
Bola2STRdStriatum dorsal region0.15
0.14
Bola2STRvStriatum ventral region0.16
0.18
Bola2THThalamus0.51
0.5
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
BOLA2_HUMAN_0 0 0 0 DLEAEHVEVEDTTLNR PRIDE
BOLA2_HUMAN_0 0 0 0 LVNACLAEELPHIHAFEQK PRIDE
BOLA2_HUMAN_0 0 0 0 TLTPDQWAR PRIDE
BOLA2_HUMAN_1 9 1 9 MELSAEYLR PRIDE
BOLA2_HUMAN_14 16 14 29 DLEAEHVEVEDTTLNR PRIDE
BOLA2_HUMAN_43 9 43 51 FEGKPLLQR PRIDE
BOLA2_HUMAN_54 19 54 72 LVNACLAEELPHIHAFEQK PRIDE
BOLA2_HUMAN_73 9 73 81 TLTPDQWAR PRIDE
PAp00005432 19 121 139 LVNACLAEELPHIHAFEQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018