AutismKB 2.0

Annotation Detail for KLHL26


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Basic Information Top
Gene Symbol:KLHL26 ( FLJ11078 )
Gene Full Name: kelch-like 26 (Drosophila)
Band: 19p13.11
Quick LinksEntrez ID:55295; OMIM: NA; Uniprot ID:KLH26_HUMAN; ENSEMBL ID: ENSG00000167487; HGNC ID: 25623
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor27 / 263845102
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal126 / 336030737
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain80 / 110098972
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye5 / 21105423
heart2 / 8962622
intestine4 / 23447217
kidney7 / 21177733
larynx0 / 241450 
liver4 / 20774319
lung8 / 33697423
lymph2 / 4427045
lymph node2 / 9161021
mammary gland1 / 1532716
mouth3 / 6705244
muscle0 / 1077150 
nerve0 / 157680 
ovary18 / 102051176
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate4 / 18934521
salivary gland1 / 2015549
skin0 / 2105740 
spleen1 / 5395218
stomach10 / 96619103
testis19 / 33044257
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219354_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.5
Adipocyte7.25
AdrenalCortex5.55
Adrenalgland4.6
Amygdala21.65
Appendix5.4
AtrioventricularNode4.25
BDCA4+_DentriticCells6.2
Bonemarrow5.35
BronchialEpithelialCells5.05
CD105+_Endothelial5.45
CD14+_Monocytes5.6
CD19+_BCells(neg._sel.)5.5
CD33+_Myeloid6.2
CD34+6.7
CD4+_Tcells5.6
CD56+_NKCells6.15
CD71+_EarlyErythroid5.6
CD8+_Tcells5.1
CardiacMyocytes6.85
Caudatenucleus11.75
Cerebellum15.75
CerebellumPeduncles9.2
CiliaryGanglion3.7
CingulateCortex6.2
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.25
FetalThyroid5.1
Fetalbrain7.7
Fetalliver4.6
Fetallung4.4
GlobusPallidus3.95
Heart6.95
Hypothalamus6.95
Kidney4.55
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-604.75
Leukemialymphoblastic(MOLT-4)4.3
Liver8.45
Lung7.1
Lymphnode4.55
Lymphoma_burkitts(Daudi)6.95
Lymphoma_burkitts(Raji)7.55
MedullaOblongata9.45
OccipitalLobe8.7
OlfactoryBulb8.15
Ovary3.6
Pancreas4.4
PancreaticIslet5.8
ParietalLobe8.45
Pituitary6.4
Placenta5.7
Pons5.25
PrefrontalCortex25.15
Prostate6.55
Salivarygland4.25
SkeletalMuscle7
Skin4.05
SmoothMuscle5.7
Spinalcord7.3
SubthalamicNucleus5.35
SuperiorCervicalGanglion6.5
TemporalLobe5.05
Testis5.6
TestisGermCell4.6
TestisIntersitial4.55
TestisLeydigCell5.25
TestisSeminiferousTubule4.3
Thalamus6.45
Thymus4.2
Thyroid9.65
Tongue5.2
Tonsil5
Trachea4.5
TrigeminalGanglion5.4
Uterus4.4
UterusCorpus6.05
WholeBlood5.55
Wholebrain31.7
colon5.4
pineal_day7.32
pineal_night7.88
retina11.125
small_intestine5.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_879_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.83 ± 0.82
Basal Forebrain2.8 ± 0.65
Basal Part of Pons2.51 ± 0.45
Cerebellar Cortex2.95 ± 0.6
Cerebellar Nuclei2.74 ± 0.65
Claustrum3.03 ± 0.82
Epithalamus2.6 ± 0.58
Frontal Lobe2.71 ± 0.69
Globus Pallidus2.32 ± 0.96
Hypothalamus2.84 ± 0.43
Insula2.8 ± 0.29
Limbic Lobe2.84 ± 0.7
Mesencephalon2.77 ± 0.71
Myelencephalon2.81 ± 0.71
Occipital Lobe2.9 ± 0.66
Parietal Lobe2.82 ± 0.59
Pontine Tegmentum2.81 ± 0.79
Striatum2.77 ± 0.65
Subthalamus2.77 ± 1.02
Temporal Lobe2.78 ± 0.72
Thalamus2.66 ± 0.69
White Matter3.1 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl26CBCerebellum15.4
19.43
Klhl26CTXCerebral cortex44.85
32.16
Klhl26HIPHippocampal region39.55
58.94
Klhl26HPFHippocampal formation37.9
45.58
Klhl26HYHypothalamus9.27
6.58
Klhl26LSXLateral septal complex12.54
9.95
Klhl26MBMidbrain11.09
9.03
Klhl26MYMedulla31.97
32.72
Klhl26OLFOlfactory bulb29.03
22.01
Klhl26PPons18.36
17.29
Klhl26PALPallidum16.32
13.57
Klhl26RHPRetrohippocampal region35.28
27.38
Klhl26sAMYStriatum-like amygdalar nuclei25.56
17.14
Klhl26STRStriatum14.73
10.03
Klhl26STRdStriatum dorsal region14.19
9.82
Klhl26STRvStriatum ventral region11.73
6.96
Klhl26THThalamus15.6
11.65
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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