AutismKB 2.0

Annotation Detail for PPP3CA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PPP3CA ( CALN,CALNA,CALNA1,CCN1,CNA1,PPP2B )
Gene Full Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Band: 4q24
Quick LinksEntrez ID:5530; OMIM: 114105; Uniprot ID:PP2BA_HUMAN; ENSEMBL ID: ENSG00000138814; HGNC ID: 9314
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus43 / 56401276
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult120 / 193912161
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma17 / 82823205
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal154 / 336030745
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer20 / 102680194
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone15 / 71655209
bone marrow1 / 4880120
brain44 / 110098939
cervix3 / 4817162
connective tissue10 / 14925566
ear1 / 1621261
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye15 / 21105471
heart2 / 8962622
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver4 / 20774319
lung19 / 33697456
lymph0 / 442700 
lymph node1 / 9161010
mammary gland13 / 15327184
mouth0 / 670520 
muscle2 / 10771518
nerve3 / 15768190
ovary5 / 10205148
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate29 / 189345153
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202429_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts152.85
Adipocyte101.25
AdrenalCortex37.5
Adrenalgland23.65
Amygdala1632.9
Appendix56.25
AtrioventricularNode23.15
BDCA4+_DentriticCells408.9
Bonemarrow23.15
BronchialEpithelialCells300.45
CD105+_Endothelial73.65
CD14+_Monocytes329.55
CD19+_BCells(neg._sel.)709.7
CD33+_Myeloid427.4
CD34+274.95
CD4+_Tcells132.9
CD56+_NKCells487.95
CD71+_EarlyErythroid29.95
CD8+_Tcells138.4
CardiacMyocytes51.25
Caudatenucleus1987.2
Cerebellum651.5
CerebellumPeduncles885.25
CiliaryGanglion26.8
CingulateCortex753.2
Colorectaladenocarcinoma20.85
DorsalRootGanglion17.5
FetalThyroid64.6
Fetalbrain510.45
Fetalliver32.25
Fetallung66.55
GlobusPallidus886.7
Heart38.5
Hypothalamus264.05
Kidney19.6
Leukemia_chronicMyelogenousK-56223.2
Leukemia_promyelocytic-HL-6049.85
Leukemialymphoblastic(MOLT-4)13.7
Liver28.55
Lung20.65
Lymphnode38.55
Lymphoma_burkitts(Daudi)35.95
Lymphoma_burkitts(Raji)42
MedullaOblongata1414.45
OccipitalLobe1187.35
OlfactoryBulb19.8
Ovary18.4
Pancreas30.3
PancreaticIslet29.1
ParietalLobe817.75
Pituitary45.35
Placenta22.5
Pons787.6
PrefrontalCortex2311.3
Prostate581.1
Salivarygland83.3
SkeletalMuscle41.85
Skin21.75
SmoothMuscle223.1
Spinalcord109.45
SubthalamicNucleus1146
SuperiorCervicalGanglion35
TemporalLobe735.65
Testis13
TestisGermCell59
TestisIntersitial23.2
TestisLeydigCell20.4
TestisSeminiferousTubule22.85
Thalamus224.5
Thymus15.55
Thyroid92.25
Tongue35.7
Tonsil39.45
Trachea106.2
TrigeminalGanglion28.05
Uterus68.35
UterusCorpus26
WholeBlood659.4
Wholebrain1027.15
colon146.95
pineal_day378.12
pineal_night432.9
retina63.675
small_intestine98.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P92623
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala12.09 ± 0.69
Basal Forebrain11.98 ± 0.4
Basal Part of Pons12.79 ± 0.24
Cerebellar Cortex11.96 ± 0.18
Cerebellar Nuclei11.06 ± 0.64
Claustrum11.91 ± 0.45
Epithalamus11.38 ± 0.43
Frontal Lobe12.01 ± 0.43
Globus Pallidus9.88 ± 0.82
Hypothalamus11.68 ± 0.45
Insula12.1 ± 0.21
Limbic Lobe12.2 ± 0.98
Mesencephalon11.52 ± 0.51
Myelencephalon11.89 ± 0.66
Occipital Lobe12.43 ± 0.44
Parietal Lobe12.17 ± 0.55
Pontine Tegmentum11.92 ± 0.42
Striatum13.06 ± 0.53
Subthalamus12.09 ± 0.3
Temporal Lobe12.1 ± 0.41
Thalamus11.49 ± 0.3
White Matter9.61 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp3caCBCerebellum100
100
Ppp3caCTXCerebral cortex100
100
Ppp3caHIPHippocampal region100
100
Ppp3caHPFHippocampal formation100
100
Ppp3caHYHypothalamus54.83
56.51
Ppp3caLSXLateral septal complex100
100
Ppp3caMBMidbrain57.98
63.4
Ppp3caMYMedulla62.93
82.84
Ppp3caOLFOlfactory bulb100
100
Ppp3caPPons43.52
54.05
Ppp3caPALPallidum49.81
63.65
Ppp3caRHPRetrohippocampal region100
100
Ppp3casAMYStriatum-like amygdalar nuclei100
100
Ppp3caSTRStriatum100
100
Ppp3caSTRdStriatum dorsal region100
100
Ppp3caSTRvStriatum ventral region100
100
Ppp3caTHThalamus82.29
99.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00025174 26 218 243 FKEPPAYGPMCDILWSDPLEDFGNEK Peptide Atlas
PP2BA_HUMAN_100 12 100 111 LFEVGGSPANTR PRIDE
PP2BA_HUMAN_2 15 2 16 SEPKAIDPKLSTTDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved