AutismKB 2.0

Annotation Detail for PPP4C


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Basic Information Top
Gene Symbol:PPP4C ( PP4,PP4C,PPH3,PPP4,PPX )
Gene Full Name: protein phosphatase 4, catalytic subunit
Band: 16p11.2
Quick LinksEntrez ID:5531; OMIM: 602035; Uniprot ID:PP4C_HUMAN; ENSEMBL ID: ENSG00000149923; HGNC ID: 9319
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst14 / 62319224
fetus29 / 56401251
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult166 / 193912185
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor14 / 94178148
cervical tumor3 / 3436687
chondrosarcoma9 / 82823108
colorectal tumor12 / 114246105
esophageal tumor1 / 1729057
gastrointestinal tumor11 / 11936992
germ cell tumor14 / 26384553
glioma13 / 106883121
head and neck tumor10 / 13630273
kidney tumor8 / 68959116
leukemia6 / 9584262
liver tumor10 / 96359103
lung tumor12 / 103127116
lymphoma8 / 71755111
non-neoplasia5 / 9725051
normal230 / 336030768
ovarian tumor15 / 76682195
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS27 / 125680214
prostate cancer9 / 10268087
retinoblastoma4 / 4635686
skin tumor20 / 124949160
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood15 / 123478121
bone12 / 71655167
bone marrow1 / 4880120
brain54 / 110098949
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue43 / 215722199
esophagus1 / 2020949
eye17 / 21105480
heart6 / 8962666
intestine26 / 234472110
kidney11 / 21177751
larynx0 / 241450 
liver15 / 20774372
lung29 / 33697486
lymph5 / 44270112
lymph node9 / 9161098
mammary gland16 / 153271104
mouth3 / 6705244
muscle1 / 1077159
nerve2 / 15768126
ovary17 / 102051166
pancreas30 / 214812139
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta34 / 280825121
prostate17 / 18934589
salivary gland2 / 2015599
skin29 / 210574137
spleen1 / 5395218
stomach2 / 9661920
testis4 / 33044212
thymus2 / 8113124
thyroid1 / 4747321
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord1 / 1368073
uterus32 / 232878137
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208932_at
Cell line Expression level Expression bar
721_B_lymphoblasts374.45
Adipocyte43.75
AdrenalCortex21.9
Adrenalgland53.35
Amygdala14.8
Appendix10.1
AtrioventricularNode7.2
BDCA4+_DentriticCells362.1
Bonemarrow91.65
BronchialEpithelialCells153.15
CD105+_Endothelial227.25
CD14+_Monocytes422.85
CD19+_BCells(neg._sel.)313.55
CD33+_Myeloid458.75
CD34+250.9
CD4+_Tcells149.7
CD56+_NKCells364.35
CD71+_EarlyErythroid134.5
CD8+_Tcells144.95
CardiacMyocytes112.6
Caudatenucleus14.2
Cerebellum28.6
CerebellumPeduncles38.95
CiliaryGanglion7.2
CingulateCortex22.05
Colorectaladenocarcinoma98.45
DorsalRootGanglion8.1
FetalThyroid34.5
Fetalbrain18.95
Fetalliver44.2
Fetallung57
GlobusPallidus7.25
Heart159.8
Hypothalamus11.35
Kidney27.1
Leukemia_chronicMyelogenousK-56262.1
Leukemia_promyelocytic-HL-6052.25
Leukemialymphoblastic(MOLT-4)182.35
Liver323.65
Lung274.4
Lymphnode20.85
Lymphoma_burkitts(Daudi)56.35
Lymphoma_burkitts(Raji)146.9
MedullaOblongata17
OccipitalLobe15.3
OlfactoryBulb16
Ovary13.75
Pancreas67.85
PancreaticIslet39.75
ParietalLobe10.45
Pituitary47
Placenta213.7
Pons11.35
PrefrontalCortex44.5
Prostate178.45
Salivarygland8.1
SkeletalMuscle12
Skin7.3
SmoothMuscle235.15
Spinalcord18.6
SubthalamicNucleus10.45
SuperiorCervicalGanglion13.65
TemporalLobe14.45
Testis162.05
TestisGermCell60.85
TestisIntersitial70.85
TestisLeydigCell36.9
TestisSeminiferousTubule63.35
Thalamus17
Thymus231.15
Thyroid78.6
Tongue20.9
Tonsil55.7
Trachea34.05
TrigeminalGanglion9.5
Uterus69.05
UterusCorpus25
WholeBlood382.5
Wholebrain47.55
colon76.7
pineal_day29.96
pineal_night39.78
retina30.975
small_intestine73.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13090_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.21 ± 0.43
Basal Forebrain4.27 ± 0.49
Basal Part of Pons4.58 ± 0.46
Cerebellar Cortex4.71 ± 0.4
Cerebellar Nuclei4.11 ± 0.69
Claustrum4.19 ± 0.64
Epithalamus4.53 ± 0.62
Frontal Lobe4.5 ± 0.43
Globus Pallidus4.22 ± 0.42
Hypothalamus4.3 ± 0.54
Insula4.38 ± 0.46
Limbic Lobe4.36 ± 0.44
Mesencephalon4.37 ± 0.46
Myelencephalon4.49 ± 0.5
Occipital Lobe4.14 ± 0.42
Parietal Lobe4.4 ± 0.46
Pontine Tegmentum4.33 ± 0.53
Striatum4.33 ± 0.44
Subthalamus4.65 ± 0.26
Temporal Lobe4.51 ± 0.45
Thalamus4.52 ± 0.52
White Matter4.36 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp4cCBCerebellum14.03
20.4
Ppp4cCTXCerebral cortex13.9
11.6
Ppp4cHIPHippocampal region22.35
27.14
Ppp4cHPFHippocampal formation18.21
20.25
Ppp4cHYHypothalamus23.15
19.69
Ppp4cLSXLateral septal complex14.51
10.56
Ppp4cMBMidbrain8.64
10.53
Ppp4cMYMedulla12.84
17.84
Ppp4cOLFOlfactory bulb32.52
27.65
Ppp4cPPons19.31
26.06
Ppp4cPALPallidum16.03
14.58
Ppp4cRHPRetrohippocampal region6.68
5.87
Ppp4csAMYStriatum-like amygdalar nuclei11.49
9.05
Ppp4cSTRStriatum9.29
7.2
Ppp4cSTRdStriatum dorsal region3.13
2.62
Ppp4cSTRvStriatum ventral region28.66
20.35
Ppp4cTHThalamus10.33
9.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000940 10 17 26 CELIKESEVK Peptide Atlas
PP4C_HUMAN_2 8 2 9 AEISDLDR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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