AutismKB 2.0

Annotation Detail for C14orf106


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Basic Information Top
Gene Symbol:C14orf106 ( FLJ11186,HSA242977,KIAA1903,KNL2,MIS18BP1 )
Gene Full Name: chromosome 14 open reading frame 106
Band: 14q21.2
Quick LinksEntrez ID:55320; OMIM: NA; Uniprot ID:KNL2_HUMAN; ENSEMBL ID: ENSG00000129534; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst12 / 62319192
fetus22 / 56401239
neonate1 / 3109732
infant1 / 2362042
juvenile1 / 5555617
adult40 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor13 / 26384549
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia1 / 9725010
normal118 / 336030735
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder2 / 2975767
blood11 / 12347889
bone3 / 7165541
bone marrow4 / 4880181
brain10 / 11009899
cervix2 / 4817141
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus0 / 202090 
eye0 / 2110540 
heart4 / 8962644
intestine7 / 23447229
kidney2 / 2117779
larynx0 / 241450 
liver10 / 20774348
lung4 / 33697411
lymph1 / 4427022
lymph node23 / 91610251
mammary gland3 / 15327119
mouth1 / 6705214
muscle5 / 10771546
nerve1 / 1576863
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta7 / 28082524
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach2 / 9661920
testis7 / 33044221
thymus8 / 8113198
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus3 / 23287812
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206500_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.65
Adipocyte7.9
AdrenalCortex11.45
Adrenalgland7.6
Amygdala8
Appendix10.4
AtrioventricularNode12.5
BDCA4+_DentriticCells10.3
Bonemarrow9.25
BronchialEpithelialCells7.6
CD105+_Endothelial8.2
CD14+_Monocytes10.45
CD19+_BCells(neg._sel.)9.1
CD33+_Myeloid37.9
CD34+13
CD4+_Tcells8.2
CD56+_NKCells10
CD71+_EarlyErythroid8.05
CD8+_Tcells7.05
CardiacMyocytes15.3
Caudatenucleus7.35
Cerebellum6.75
CerebellumPeduncles11.1
CiliaryGanglion8.6
CingulateCortex9.05
Colorectaladenocarcinoma8.25
DorsalRootGanglion9.1
FetalThyroid8.85
Fetalbrain7.65
Fetalliver7.4
Fetallung6.1
GlobusPallidus6.95
Heart15.4
Hypothalamus8.2
Kidney7.95
Leukemia_chronicMyelogenousK-5627.3
Leukemia_promyelocytic-HL-607.2
Leukemialymphoblastic(MOLT-4)6.05
Liver13.6
Lung8.75
Lymphnode6.55
Lymphoma_burkitts(Daudi)11.5
Lymphoma_burkitts(Raji)13.15
MedullaOblongata7.2
OccipitalLobe7.2
OlfactoryBulb6.25
Ovary6.25
Pancreas7
PancreaticIslet8.95
ParietalLobe9.55
Pituitary9.55
Placenta7.8
Pons8.55
PrefrontalCortex9.2
Prostate9.2
Salivarygland7.1
SkeletalMuscle15.75
Skin8.25
SmoothMuscle9.2
Spinalcord8.5
SubthalamicNucleus8.15
SuperiorCervicalGanglion13.65
TemporalLobe7.95
Testis6.9
TestisGermCell6.4
TestisIntersitial7.1
TestisLeydigCell9.35
TestisSeminiferousTubule7
Thalamus8.65
Thymus6
Thyroid9.45
Tongue10.9
Tonsil8.3
Trachea6.65
TrigeminalGanglion11.95
Uterus6.3
UterusCorpus10.1
WholeBlood8.9
Wholebrain6.2
colon8.15
pineal_day9.76
pineal_night9.62
retina9.875
small_intestine7.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P106162
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.71 ± 0.38
Basal Forebrain6.24 ± 0.24
Basal Part of Pons6.95 ± 0.41
Cerebellar Cortex5.91 ± 0.33
Cerebellar Nuclei6.6 ± 0.23
Claustrum6.17 ± 0.39
Epithalamus6.51 ± 0.35
Frontal Lobe6.22 ± 0.37
Globus Pallidus6.86 ± 0.25
Hypothalamus6.19 ± 0.33
Insula6.31 ± 0.39
Limbic Lobe6.59 ± 0.55
Mesencephalon6.35 ± 0.43
Myelencephalon6.4 ± 0.45
Occipital Lobe7.17 ± 0.46
Parietal Lobe6.64 ± 0.37
Pontine Tegmentum6.26 ± 0.36
Striatum6.7 ± 0.32
Subthalamus6.44 ± 0.28
Temporal Lobe6.5 ± 0.37
Thalamus6.07 ± 0.38
White Matter6.43 ± 0.18
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KNL2_HUMAN_1093 15 1093 1107 TPFNTDLGENSGIGK PRIDE
KNL2_HUMAN_1094 15 1094 1108 TPFNTDLGENSGIGK PRIDE
KNL2_HUMAN_809 23 809 831 NTSNIPVILEPETEESENEFYIK PRIDE
KNL2_HUMAN_984 16 984 999 DDHDDFFSTTPLQHQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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