AutismKB 2.0

Annotation Detail for LSG1


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Basic Information Top
Gene Symbol:LSG1 ( FLJ11301,FLJ27294 )
Gene Full Name: large subunit GTPase 1 homolog (S. cerevisiae)
Band: 3q29
Quick LinksEntrez ID:55341; OMIM: 610780; Uniprot ID:LSG1_HUMAN; ENSEMBL ID: ENSG00000041802; HGNC ID: 25652
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221535_at
Cell line Expression level Expression bar
721_B_lymphoblasts52.15
Adipocyte29.2
AdrenalCortex20.35
Adrenalgland16.95
Amygdala21.45
Appendix25.35
AtrioventricularNode18.95
BDCA4+_DentriticCells36.25
Bonemarrow24.9
BronchialEpithelialCells23.8
CD105+_Endothelial25.9
CD14+_Monocytes35.15
CD19+_BCells(neg._sel.)31.75
CD33+_Myeloid31.5
CD34+113.55
CD4+_Tcells53.6
CD56+_NKCells33.2
CD71+_EarlyErythroid13.65
CD8+_Tcells64.65
CardiacMyocytes141.05
Caudatenucleus32.85
Cerebellum18.85
CerebellumPeduncles31.35
CiliaryGanglion18.1
CingulateCortex28.45
Colorectaladenocarcinoma38.6
DorsalRootGanglion19.8
FetalThyroid48.95
Fetalbrain31.45
Fetalliver19.75
Fetallung21.75
GlobusPallidus22.15
Heart26.8
Hypothalamus37.05
Kidney22.35
Leukemia_chronicMyelogenousK-56232.6
Leukemia_promyelocytic-HL-6021.1
Leukemialymphoblastic(MOLT-4)41.95
Liver24.2
Lung21.3
Lymphnode33.95
Lymphoma_burkitts(Daudi)89.75
Lymphoma_burkitts(Raji)28.25
MedullaOblongata30.1
OccipitalLobe11.9
OlfactoryBulb23.75
Ovary16.7
Pancreas19.25
PancreaticIslet46.8
ParietalLobe19.35
Pituitary34.45
Placenta25.05
Pons29.45
PrefrontalCortex27.85
Prostate20.6
Salivarygland19.8
SkeletalMuscle39
Skin24.25
SmoothMuscle34.45
Spinalcord28.55
SubthalamicNucleus24.15
SuperiorCervicalGanglion30.15
TemporalLobe20.7
Testis16.45
TestisGermCell19.15
TestisIntersitial14
TestisLeydigCell32.2
TestisSeminiferousTubule40.9
Thalamus34.7
Thymus38.45
Thyroid27.95
Tongue17.2
Tonsil24.4
Trachea28.35
TrigeminalGanglion31.4
Uterus15.05
UterusCorpus22
WholeBlood28.85
Wholebrain16.05
colon21.8
pineal_day40.58
pineal_night30.36
retina41.75
small_intestine23.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P148657
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.75 ± 0.46
Basal Forebrain6.08 ± 0.28
Basal Part of Pons6.39 ± 0.23
Cerebellar Cortex6.01 ± 0.31
Cerebellar Nuclei6.27 ± 0.28
Claustrum5.7 ± 0.71
Epithalamus6.19 ± 0.5
Frontal Lobe6.26 ± 0.33
Globus Pallidus6.2 ± 0.37
Hypothalamus6.44 ± 0.21
Insula6.2 ± 0.23
Limbic Lobe5.98 ± 0.43
Mesencephalon6.15 ± 0.33
Myelencephalon6.05 ± 0.44
Occipital Lobe5.73 ± 0.39
Parietal Lobe6.07 ± 0.36
Pontine Tegmentum5.99 ± 0.46
Striatum5.97 ± 0.33
Subthalamus6.06 ± 0.78
Temporal Lobe6.07 ± 0.33
Thalamus6.1 ± 0.31
White Matter6.86 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lsg1CBCerebellum3.78
3.56
Lsg1CTXCerebral cortex2.86
1.78
Lsg1HIPHippocampal region3.55
3.24
Lsg1HPFHippocampal formation3.48
2.83
Lsg1HYHypothalamus0.47
0.35
Lsg1LSXLateral septal complex0.92
0.56
Lsg1MBMidbrain1.23
1.2
Lsg1MYMedulla4.03
3.94
Lsg1OLFOlfactory bulb4.89
3.03
Lsg1PPons2.32
2.39
Lsg1PALPallidum1.38
1.26
Lsg1RHPRetrohippocampal region3.43
2.3
Lsg1sAMYStriatum-like amygdalar nuclei0.7
0.46
Lsg1STRStriatum1.55
1.1
Lsg1STRdStriatum dorsal region1.17
0.79
Lsg1STRvStriatum ventral region3.43
2.45
Lsg1THThalamus1.79
1.37
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004962 13 103 115 LHEENKQFLCIPR Peptide Atlas

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018