AutismKB 2.0

Annotation Detail for LAPTM4B


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Basic Information Top
Gene Symbol:LAPTM4B ( LAPTM4beta,LC27 )
Gene Full Name: lysosomal protein transmembrane 4 beta
Band: 8q22.1
Quick LinksEntrez ID:55353; OMIM: 613296; Uniprot ID:LAP4B_HUMAN; ENSEMBL ID: ENSG00000104341; HGNC ID: 13646
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body29 / 70761409
blastocyst22 / 62319353
fetus85 / 564012150
neonate5 / 31097160
infant5 / 23620211
juvenile16 / 55556287
adult369 / 1939121190
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor6 / 12794468
bladder carcinoma1 / 1747557
breast (mammary gland) tumor11 / 94178116
cervical tumor12 / 34366349
chondrosarcoma17 / 82823205
colorectal tumor15 / 114246131
esophageal tumor2 / 17290115
gastrointestinal tumor61 / 119369511
germ cell tumor88 / 263845333
glioma24 / 106883224
head and neck tumor14 / 136302102
kidney tumor27 / 68959391
leukemia5 / 9584252
liver tumor17 / 96359176
lung tumor25 / 103127242
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal498 / 3360307148
ovarian tumor39 / 76682508
pancreatic tumor28 / 104616267
primitive neuroectodermal tumor of the CNS54 / 125680429
prostate cancer12 / 102680116
retinoblastoma18 / 46356388
skin tumor37 / 124949296
soft tissue/muscle tissue tumor54 / 125191431
uterine tumor58 / 90257642
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland8 / 33197240
ascites16 / 40015399
bladder6 / 29757201
blood4 / 12347832
bone22 / 71655307
bone marrow2 / 4880140
brain154 / 1100989139
cervix16 / 48171332
connective tissue49 / 149255328
ear4 / 16212246
embryonic tissue92 / 215722426
esophagus2 / 2020998
eye80 / 211054379
heart41 / 89626457
intestine36 / 234472153
kidney48 / 211777226
larynx5 / 24145207
liver29 / 207743139
lung62 / 336974183
lymph0 / 442700 
lymph node6 / 9161065
mammary gland13 / 15327184
mouth7 / 67052104
muscle18 / 107715167
nerve2 / 15768126
ovary46 / 102051450
pancreas40 / 214812186
parathyroid11 / 20539535
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta22 / 28082578
prostate16 / 18934584
salivary gland2 / 2015599
skin56 / 210574265
spleen4 / 5395274
stomach32 / 96619331
testis85 / 330442257
thymus2 / 8113124
thyroid7 / 47473147
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord4 / 13680292
uterus72 / 232878309
vascular3 / 5178057
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208767_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.6
Adipocyte73.8
AdrenalCortex55.95
Adrenalgland113.4
Amygdala117.15
Appendix18.7
AtrioventricularNode29.25
BDCA4+_DentriticCells6.35
Bonemarrow46.1
BronchialEpithelialCells301.5
CD105+_Endothelial7.2
CD14+_Monocytes12.65
CD19+_BCells(neg._sel.)6.85
CD33+_Myeloid9.35
CD34+159.3
CD4+_Tcells8.9
CD56+_NKCells7.9
CD71+_EarlyErythroid7.6
CD8+_Tcells7.05
CardiacMyocytes161.65
Caudatenucleus48.15
Cerebellum59.65
CerebellumPeduncles72.75
CiliaryGanglion13.5
CingulateCortex49.1
Colorectaladenocarcinoma181.7
DorsalRootGanglion24.6
FetalThyroid41.35
Fetalbrain34.65
Fetalliver142.5
Fetallung101.6
GlobusPallidus25.8
Heart240.2
Hypothalamus145.35
Kidney106.8
Leukemia_chronicMyelogenousK-562954.65
Leukemia_promyelocytic-HL-607.05
Leukemialymphoblastic(MOLT-4)54.6
Liver89.65
Lung216.05
Lymphnode42.7
Lymphoma_burkitts(Daudi)14.25
Lymphoma_burkitts(Raji)21.85
MedullaOblongata54.15
OccipitalLobe59.95
OlfactoryBulb43.15
Ovary86.35
Pancreas158.4
PancreaticIslet333.35
ParietalLobe66.05
Pituitary100.95
Placenta68.3
Pons45.1
PrefrontalCortex74.35
Prostate77.05
Salivarygland93
SkeletalMuscle26.55
Skin39.2
SmoothMuscle156.65
Spinalcord131.1
SubthalamicNucleus20
SuperiorCervicalGanglion76.5
TemporalLobe52.9
Testis206.6
TestisGermCell315.85
TestisIntersitial71.3
TestisLeydigCell104.9
TestisSeminiferousTubule85.3
Thalamus103.1
Thymus23
Thyroid272.2
Tongue18.25
Tonsil25.05
Trachea110.6
TrigeminalGanglion43.75
Uterus85.8
UterusCorpus123.9
WholeBlood16.3
Wholebrain200.15
colon173.25
pineal_day1464.38
pineal_night990.6
retina818.3
small_intestine382.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P414999
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.49 ± 0.91
Basal Forebrain5.85 ± 0.41
Basal Part of Pons6.08 ± 0.42
Cerebellar Cortex5.99 ± 0.54
Cerebellar Nuclei6.37 ± 0.67
Claustrum5.02 ± 1.01
Epithalamus6.51 ± 0.73
Frontal Lobe6.18 ± 0.57
Globus Pallidus6.67 ± 0.33
Hypothalamus6.35 ± 0.93
Insula5.93 ± 0.43
Limbic Lobe5.32 ± 0.64
Mesencephalon6.16 ± 0.67
Myelencephalon5.96 ± 0.69
Occipital Lobe5.97 ± 0.56
Parietal Lobe6.21 ± 0.74
Pontine Tegmentum6.17 ± 0.58
Striatum5.32 ± 0.54
Subthalamus6.25 ± 0.54
Temporal Lobe5.9 ± 0.58
Thalamus6.39 ± 0.54
White Matter6.47 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Laptm4bCBCerebellum33.06
99.8
Laptm4bCTXCerebral cortex63.22
59.27
Laptm4bHIPHippocampal region32.74
58.91
Laptm4bHPFHippocampal formation39.63
50.79
Laptm4bHYHypothalamus27.93
18.18
Laptm4bLSXLateral septal complex62.48
55.45
Laptm4bMBMidbrain44.32
43.31
Laptm4bMYMedulla50.98
64.69
Laptm4bOLFOlfactory bulb66.22
64.35
Laptm4bPPons45.31
52.25
Laptm4bPALPallidum33.24
30.27
Laptm4bRHPRetrohippocampal region47.58
40.85
Laptm4bsAMYStriatum-like amygdalar nuclei30.22
19.49
Laptm4bSTRStriatum18.49
14.35
Laptm4bSTRdStriatum dorsal region12.67
10.11
Laptm4bSTRvStriatum ventral region14.98
10.82
Laptm4bTHThalamus37.09
32.29
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018