AutismKB 2.0

Annotation Detail for PPP5C


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Basic Information Top
Gene Symbol:PPP5C ( FLJ36922,PP5,PPP5 )
Gene Full Name: protein phosphatase 5, catalytic subunit
Band: 19q13.32
Quick LinksEntrez ID:5536; OMIM: 600658; Uniprot ID:PPP5_HUMAN; ENSEMBL ID: ENSG00000011485; HGNC ID: 9322
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst10 / 62319160
fetus64 / 564012113
neonate6 / 31097192
infant4 / 23620169
juvenile16 / 55556287
adult170 / 193912187
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma13 / 82823156
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor15 / 119369125
germ cell tumor51 / 263845193
glioma13 / 106883121
head and neck tumor6 / 13630244
kidney tumor10 / 68959145
leukemia10 / 95842104
liver tumor13 / 96359134
lung tumor16 / 103127155
lymphoma8 / 71755111
non-neoplasia8 / 9725082
normal334 / 336030799
ovarian tumor2 / 7668226
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS35 / 125680278
prostate cancer15 / 102680146
retinoblastoma4 / 4635686
skin tumor41 / 124949328
soft tissue/muscle tissue tumor23 / 125191183
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites7 / 40015174
bladder9 / 29757302
blood19 / 123478153
bone7 / 7165597
bone marrow2 / 4880140
brain149 / 1100989135
cervix5 / 48171103
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus1 / 2020949
eye21 / 21105499
heart11 / 89626122
intestine32 / 234472136
kidney26 / 211777122
larynx1 / 2414541
liver14 / 20774367
lung40 / 336974118
lymph8 / 44270180
lymph node1 / 9161010
mammary gland7 / 15327145
mouth2 / 6705229
muscle13 / 107715120
nerve0 / 157680 
ovary10 / 10205197
pancreas16 / 21481274
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta24 / 28082585
prostate21 / 189345110
salivary gland2 / 2015599
skin48 / 210574227
spleen2 / 5395237
stomach7 / 9661972
testis28 / 33044284
thymus10 / 81131123
thyroid2 / 4747342
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord3 / 13680219
uterus22 / 23287894
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201979_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts27.75
Adipocyte3.9
AdrenalCortex3.75
Adrenalgland3.85
Amygdala3.95
Appendix3.65
AtrioventricularNode2.75
BDCA4+_DentriticCells7.8
Bonemarrow3.6
BronchialEpithelialCells3.65
CD105+_Endothelial3.85
CD14+_Monocytes3.3
CD19+_BCells(neg._sel.)3.9
CD33+_Myeloid4.85
CD34+4.85
CD4+_Tcells4.15
CD56+_NKCells5.05
CD71+_EarlyErythroid3.45
CD8+_Tcells3.7
CardiacMyocytes4.5
Caudatenucleus3.3
Cerebellum3.8
CerebellumPeduncles6.2
CiliaryGanglion2.5
CingulateCortex5.45
Colorectaladenocarcinoma3.75
DorsalRootGanglion2.75
FetalThyroid3.6
Fetalbrain5.25
Fetalliver3.2
Fetallung3.05
GlobusPallidus2.65
Heart4.65
Hypothalamus4.1
Kidney2.9
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3.15
Liver4.75
Lung5
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.7
Lymphoma_burkitts(Raji)5.1
MedullaOblongata3.45
OccipitalLobe3.4
OlfactoryBulb2.95
Ovary2.45
Pancreas2.95
PancreaticIslet3.9
ParietalLobe3.85
Pituitary6.8
Placenta3.9
Pons3.5
PrefrontalCortex4.75
Prostate4.4
Salivarygland2.9
SkeletalMuscle4.05
Skin2.75
SmoothMuscle4.25
Spinalcord3.95
SubthalamicNucleus3.9
SuperiorCervicalGanglion4.05
TemporalLobe6.25
Testis3.2
TestisGermCell3.15
TestisIntersitial3.05
TestisLeydigCell3.65
TestisSeminiferousTubule3.2
Thalamus3.7
Thymus3
Thyroid4.7
Tongue3.55
Tonsil3.6
Trachea3.1
TrigeminalGanglion3.6
Uterus2.55
UterusCorpus3.15
WholeBlood4
Wholebrain4.95
colon3.65
pineal_day4.92
pineal_night4.88
retina4.85
small_intestine3.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7721_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.09 ± 0.5
Basal Forebrain4.78 ± 0.5
Basal Part of Pons5.58 ± 0.17
Cerebellar Cortex5.22 ± 0.33
Cerebellar Nuclei5.07 ± 0.54
Claustrum4.94 ± 0.57
Epithalamus4.8 ± 0.4
Frontal Lobe5.12 ± 0.45
Globus Pallidus4.26 ± 0.33
Hypothalamus4.72 ± 0.47
Insula5.21 ± 0.19
Limbic Lobe5.09 ± 0.38
Mesencephalon4.99 ± 0.45
Myelencephalon4.96 ± 0.53
Occipital Lobe4.94 ± 0.4
Parietal Lobe4.94 ± 0.45
Pontine Tegmentum4.79 ± 0.42
Striatum4.4 ± 0.61
Subthalamus4.76 ± 0.28
Temporal Lobe5.15 ± 0.38
Thalamus4.97 ± 0.5
White Matter4.13 ± 0.71
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp5cCBCerebellum74.3
100
Ppp5cCTXCerebral cortex100
100
Ppp5cHIPHippocampal region100
100
Ppp5cHPFHippocampal formation100
100
Ppp5cHYHypothalamus54.53
62.5
Ppp5cLSXLateral septal complex92.4
85.34
Ppp5cMBMidbrain80.24
98.14
Ppp5cMYMedulla72.6
100
Ppp5cOLFOlfactory bulb99.88
100
Ppp5cPPons58.23
89.11
Ppp5cPALPallidum61.11
81.12
Ppp5cRHPRetrohippocampal region100
100
Ppp5csAMYStriatum-like amygdalar nuclei67.62
73.06
Ppp5cSTRStriatum42.94
42.68
Ppp5cSTRdStriatum dorsal region30.78
30.41
Ppp5cSTRvStriatum ventral region52.25
49.49
Ppp5cTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003176 12 401 412 GVSCQFGPDVTK Peptide Atlas
PPP5_HUMAN_348 20 348 367 VLIMHGGLFSEDGVTLDDIR PRIDE
PPP5_HUMAN_426 16 426 441 SHEVKAEGYEVAHGGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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