AutismKB 2.0

Annotation Detail for TMEM176A


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Basic Information Top
Gene Symbol:TMEM176A ( GS188,HCA112 )
Gene Full Name: transmembrane protein 176A
Band: 7q36.1
Quick LinksEntrez ID:55365; OMIM: 610334; Uniprot ID:T176A_HUMAN; ENSEMBL ID: ENSG00000002933; HGNC ID: 24930
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus25 / 56401244
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult117 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor9 / 11424678
esophageal tumor3 / 17290173
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor10 / 10312796
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal148 / 336030744
ovarian tumor13 / 76682169
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow0 / 488010 
brain11 / 11009899
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus3 / 20209148
eye24 / 211054113
heart4 / 8962644
intestine18 / 23447276
kidney9 / 21177742
larynx0 / 241450 
liver12 / 20774357
lung18 / 33697453
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary16 / 102051156
pancreas27 / 214812125
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta17 / 28082560
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach3 / 9661931
testis0 / 3304420 
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218345_at
Cell line Expression level Expression bar
721_B_lymphoblasts48.35
Adipocyte132.7
AdrenalCortex98.75
Adrenalgland126.4
Amygdala132.9
Appendix316.3
AtrioventricularNode125.15
BDCA4+_DentriticCells53.9
Bonemarrow89.6
BronchialEpithelialCells48.55
CD105+_Endothelial49.65
CD14+_Monocytes1707.15
CD19+_BCells(neg._sel.)19.6
CD33+_Myeloid257.4
CD34+39.5
CD4+_Tcells56.25
CD56+_NKCells28.15
CD71+_EarlyErythroid64.25
CD8+_Tcells36.1
CardiacMyocytes87.45
Caudatenucleus100.2
Cerebellum96.5
CerebellumPeduncles104.6
CiliaryGanglion116.55
CingulateCortex59.8
Colorectaladenocarcinoma86.1
DorsalRootGanglion246.35
FetalThyroid100.45
Fetalbrain78.65
Fetalliver1473.7
Fetallung408.75
GlobusPallidus59.95
Heart220.85
Hypothalamus110.9
Kidney2241.65
Leukemia_chronicMyelogenousK-56273.35
Leukemia_promyelocytic-HL-6052.45
Leukemialymphoblastic(MOLT-4)43.7
Liver8885.6
Lung372.4
Lymphnode263.3
Lymphoma_burkitts(Daudi)73.05
Lymphoma_burkitts(Raji)104.1
MedullaOblongata84.75
OccipitalLobe77.3
OlfactoryBulb194.65
Ovary300.85
Pancreas432.7
PancreaticIslet766.9
ParietalLobe78.15
Pituitary121.55
Placenta326.95
Pons72.25
PrefrontalCortex148.85
Prostate134.85
Salivarygland98
SkeletalMuscle112.95
Skin90.35
SmoothMuscle60.35
Spinalcord206.75
SubthalamicNucleus89.55
SuperiorCervicalGanglion176.05
TemporalLobe91.05
Testis83.2
TestisGermCell91.9
TestisIntersitial56
TestisLeydigCell94.7
TestisSeminiferousTubule89.15
Thalamus70.2
Thymus109.65
Thyroid158.25
Tongue109
Tonsil234.35
Trachea86.75
TrigeminalGanglion204.05
Uterus94.95
UterusCorpus74.75
WholeBlood316.85
Wholebrain101.05
colon250.4
pineal_day119.62
pineal_night106.5
retina1117.4
small_intestine213.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5756_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.49 ± 0.48
Basal Forebrain4.36 ± 0.54
Basal Part of Pons3.68 ± 0.52
Cerebellar Cortex3.52 ± 0.46
Cerebellar Nuclei4.25 ± 0.6
Claustrum4.06 ± 0.84
Epithalamus5.45 ± 0.78
Frontal Lobe4.02 ± 0.75
Globus Pallidus5.92 ± 0.42
Hypothalamus4.54 ± 0.7
Insula4.51 ± 0.39
Limbic Lobe3.95 ± 0.77
Mesencephalon4.5 ± 0.74
Myelencephalon4.32 ± 0.59
Occipital Lobe3.61 ± 0.77
Parietal Lobe4.04 ± 0.76
Pontine Tegmentum4.23 ± 0.85
Striatum4.74 ± 0.54
Subthalamus4.41 ± 0.36
Temporal Lobe4.35 ± 0.65
Thalamus4.36 ± 0.67
White Matter4.14 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
0610011I04RikCBCerebellum3.64
5.75
0610011I04RikCTXCerebral cortex4.19
3.6
0610011I04RikHIPHippocampal region7.61
9.47
0610011I04RikHPFHippocampal formation8.81
9.33
0610011I04RikHYHypothalamus26.28
24.63
0610011I04RikLSXLateral septal complex3.25
2.54
0610011I04RikMBMidbrain6.64
7.94
0610011I04RikMYMedulla6.86
8.69
0610011I04RikOLFOlfactory bulb13.24
10.72
0610011I04RikPPons11.62
14.56
0610011I04RikPALPallidum8.82
11.84
0610011I04RikRHPRetrohippocampal region10.41
9.12
0610011I04RiksAMYStriatum-like amygdalar nuclei10.21
8.83
0610011I04RikSTRStriatum4.18
3.81
0610011I04RikSTRdStriatum dorsal region2.92
3.08
0610011I04RikSTRvStriatum ventral region5.81
4.35
0610011I04RikTHThalamus7.06
7.39
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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