AutismKB 2.0

Annotation Detail for LGR4


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Basic Information Top
Gene Symbol:LGR4 ( GPR48 )
Gene Full Name: leucine-rich repeat-containing G protein-coupled receptor 4
Band: 11p14.1
Quick LinksEntrez ID:55366; OMIM: 606666; Uniprot ID:LGR4_HUMAN; ENSEMBL ID: ENSG00000205213; HGNC ID: 13299
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult104 / 193912153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor19 / 114246166
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor15 / 26384556
glioma1 / 1068839
head and neck tumor5 / 13630236
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal146 / 336030743
ovarian tumor10 / 76682130
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue1 / 1492556
ear4 / 16212246
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye6 / 21105428
heart4 / 8962644
intestine26 / 234472110
kidney32 / 211777151
larynx0 / 241450 
liver18 / 20774386
lung23 / 33697468
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth4 / 6705259
muscle4 / 10771537
nerve1 / 1576863
ovary10 / 10205197
pancreas6 / 21481227
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta30 / 280825106
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach11 / 96619113
testis24 / 33044272
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218326_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.7
Adipocyte9.3
AdrenalCortex21.85
Adrenalgland10.05
Amygdala11.5
Appendix18.65
AtrioventricularNode11.3
BDCA4+_DentriticCells7.8
Bonemarrow10.65
BronchialEpithelialCells31.3
CD105+_Endothelial14.9
CD14+_Monocytes10.4
CD19+_BCells(neg._sel.)9.9
CD33+_Myeloid10.3
CD34+10.9
CD4+_Tcells8
CD56+_NKCells9.15
CD71+_EarlyErythroid9.7
CD8+_Tcells7.15
CardiacMyocytes32.75
Caudatenucleus9.15
Cerebellum8.5
CerebellumPeduncles13.35
CiliaryGanglion12.8
CingulateCortex10.45
Colorectaladenocarcinoma9.2
DorsalRootGanglion10.55
FetalThyroid13.3
Fetalbrain9.05
Fetalliver66.1
Fetallung7.5
GlobusPallidus7.8
Heart16.9
Hypothalamus10.05
Kidney14.25
Leukemia_chronicMyelogenousK-5627.95
Leukemia_promyelocytic-HL-607.55
Leukemialymphoblastic(MOLT-4)6.35
Liver16.6
Lung9.6
Lymphnode6.65
Lymphoma_burkitts(Daudi)12.35
Lymphoma_burkitts(Raji)14.75
MedullaOblongata7.6
OccipitalLobe9.45
OlfactoryBulb7.8
Ovary7.8
Pancreas15.35
PancreaticIslet28.05
ParietalLobe11.6
Pituitary12.1
Placenta79.65
Pons10.45
PrefrontalCortex12.05
Prostate15.1
Salivarygland10.85
SkeletalMuscle20
Skin13.85
SmoothMuscle20.5
Spinalcord14.75
SubthalamicNucleus9.95
SuperiorCervicalGanglion18.05
TemporalLobe12
Testis8.7
TestisGermCell12.85
TestisIntersitial8.4
TestisLeydigCell10.45
TestisSeminiferousTubule8.1
Thalamus9.95
Thymus6.2
Thyroid39.25
Tongue16.95
Tonsil9.85
Trachea10.25
TrigeminalGanglion13.5
Uterus15.6
UterusCorpus10.7
WholeBlood9.2
Wholebrain8.3
colon166.7
pineal_day12.8
pineal_night13.54
retina20.625
small_intestine51
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P17765
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.17 ± 0.83
Basal Forebrain6.92 ± 0.29
Basal Part of Pons7.32 ± 0.36
Cerebellar Cortex7.04 ± 0.56
Cerebellar Nuclei7.16 ± 0.49
Claustrum7.44 ± 0.67
Epithalamus6.44 ± 0.38
Frontal Lobe7.11 ± 0.58
Globus Pallidus7.61 ± 0.7
Hypothalamus6.92 ± 0.81
Insula7.03 ± 0.49
Limbic Lobe7.25 ± 0.61
Mesencephalon6.92 ± 0.55
Myelencephalon7.12 ± 0.66
Occipital Lobe7.28 ± 0.61
Parietal Lobe7.03 ± 0.51
Pontine Tegmentum7.09 ± 0.5
Striatum7.31 ± 0.54
Subthalamus6.7 ± 0.08
Temporal Lobe7.06 ± 0.62
Thalamus7.08 ± 0.56
White Matter7.56 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lgr4CBCerebellum19.51
27.98
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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