AutismKB 2.0

Annotation Detail for PRB4


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Basic Information Top
Gene Symbol:PRB4 ( Po )
Gene Full Name: proline-rich protein BstNI subfamily 4
Band: 12p13.2
Quick LinksEntrez ID:5545; OMIM: 180990; Uniprot ID:PRB4_HUMAN; ENSEMBL ID: ENSG00000230657; HGNC ID: 9340
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal2 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216881_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.75
Adipocyte8.85
AdrenalCortex11.65
Adrenalgland11.3
Amygdala9.1
Appendix10.35
AtrioventricularNode7.9
BDCA4+_DentriticCells8.05
Bonemarrow10.8
BronchialEpithelialCells9.05
CD105+_Endothelial8.4
CD14+_Monocytes9.55
CD19+_BCells(neg._sel.)8.9
CD33+_Myeloid10.2
CD34+9.35
CD4+_Tcells8.2
CD56+_NKCells8.7
CD71+_EarlyErythroid7.65
CD8+_Tcells7.25
CardiacMyocytes16.5
Caudatenucleus9.05
Cerebellum13.4
CerebellumPeduncles14.1
CiliaryGanglion7.6
CingulateCortex9.85
Colorectaladenocarcinoma9.5
DorsalRootGanglion8.3
FetalThyroid10.5
Fetalbrain9.55
Fetalliver8.6
Fetallung7.8
GlobusPallidus7.25
Heart17.3
Hypothalamus10.25
Kidney10.75
Leukemia_chronicMyelogenousK-5628.55
Leukemia_promyelocytic-HL-608.25
Leukemialymphoblastic(MOLT-4)7.6
Liver15.15
Lung12.85
Lymphnode11.35
Lymphoma_burkitts(Daudi)13.55
Lymphoma_burkitts(Raji)13.8
MedullaOblongata8.4
OccipitalLobe9.3
OlfactoryBulb7.2
Ovary8.75
Pancreas7.05
PancreaticIslet10.1
ParietalLobe11.15
Pituitary11.2
Placenta8.45
Pons11
PrefrontalCortex9.7
Prostate10.9
Salivarygland4841.15
SkeletalMuscle17.7
Skin9.5
SmoothMuscle9.9
Spinalcord11.05
SubthalamicNucleus9.3
SuperiorCervicalGanglion19.35
TemporalLobe9.05
Testis18.15
TestisGermCell7.55
TestisIntersitial13.15
TestisLeydigCell10.1
TestisSeminiferousTubule14.75
Thalamus129
Thymus22.35
Thyroid15.1
Tongue11.95
Tonsil9.25
Trachea8216.05
TrigeminalGanglion11.25
Uterus7.1
UterusCorpus13.75
WholeBlood9.3
Wholebrain6.9
colon9.7
pineal_day10.38
pineal_night9.88
retina14.7
small_intestine8.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P116872
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.59 ± 0.76
Basal Forebrain6.04 ± 0.29
Basal Part of Pons6.1 ± 0.25
Cerebellar Cortex5.91 ± 0.56
Cerebellar Nuclei5.83 ± 0.36
Claustrum6.74 ± 0.69
Epithalamus5.11 ± 0.35
Frontal Lobe5.83 ± 0.51
Globus Pallidus5.53 ± 0.4
Hypothalamus5.67 ± 0.37
Insula5.83 ± 0.46
Limbic Lobe6.27 ± 0.6
Mesencephalon6.07 ± 0.48
Myelencephalon6.06 ± 0.58
Occipital Lobe6.52 ± 0.65
Parietal Lobe6.19 ± 0.54
Pontine Tegmentum5.89 ± 0.63
Striatum6.62 ± 0.42
Subthalamus5.86 ± 0.12
Temporal Lobe6 ± 0.61
Thalamus6 ± 0.45
White Matter4.81 ± 0.16
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00033309 18 22 39 DVSQEESLFLISGKPEGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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