AutismKB 2.0

Annotation Detail for HES6


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Basic Information Top
Gene Symbol:HES6 ( HES-6,bHLHb41,bHLHc23 )
Gene Full Name: hairy and enhancer of split 6 (Drosophila)
Band: 2q37.3
Quick LinksEntrez ID:55502; OMIM: 610331; Uniprot ID:HES6_HUMAN; ENSEMBL ID: ENSG00000144485; HGNC ID: 18254
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult40 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor6 / 26384522
glioma43 / 106883402
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor17 / 103127164
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal64 / 336030719
ovarian tumor7 / 7668291
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer6 / 10268058
retinoblastoma9 / 46356194
skin tumor19 / 124949152
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites6 / 40015149
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain64 / 110098958
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye15 / 21105471
heart0 / 896260 
intestine11 / 23447246
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung20 / 33697459
lymph0 / 442700 
lymph node4 / 9161043
mammary gland5 / 15327132
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary9 / 10205188
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate8 / 18934542
salivary gland0 / 201550 
skin25 / 210574118
spleen0 / 539520 
stomach0 / 966190 
testis8 / 33044224
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P131202
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.99 ± 0.8
Basal Forebrain4.15 ± 0.49
Basal Part of Pons4.64 ± 1.56
Cerebellar Cortex3.99 ± 0.79
Cerebellar Nuclei4.32 ± 0.49
Claustrum3.92 ± 1.02
Epithalamus4.93 ± 0.61
Frontal Lobe4.39 ± 0.88
Globus Pallidus4.37 ± 0.45
Hypothalamus4.08 ± 0.43
Insula4.03 ± 1.12
Limbic Lobe3.98 ± 0.87
Mesencephalon4.11 ± 0.83
Myelencephalon4.27 ± 0.71
Occipital Lobe5.09 ± 0.81
Parietal Lobe4.59 ± 0.85
Pontine Tegmentum4.18 ± 0.67
Striatum3.77 ± 0.83
Subthalamus4.12 ± 0.2
Temporal Lobe4.09 ± 0.75
Thalamus4.15 ± 0.96
White Matter4.49 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hes6CBCerebellum100
100
Hes6CTXCerebral cortex100
100
Hes6HIPHippocampal region99.83
87.45
Hes6HPFHippocampal formation100
100
Hes6HYHypothalamus88.98
82.41
Hes6LSXLateral septal complex100
80.22
Hes6MBMidbrain100
91.52
Hes6MYMedulla100
100
Hes6OLFOlfactory bulb100
100
Hes6PPons100
100
Hes6PALPallidum100
93.53
Hes6RHPRetrohippocampal region100
100
Hes6sAMYStriatum-like amygdalar nuclei81.36
72.89
Hes6STRStriatum100
88.04
Hes6STRdStriatum dorsal region100
84.42
Hes6STRvStriatum ventral region100
100
Hes6THThalamus94.11
80.8
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018