AutismKB 2.0

Annotation Detail for SRGN


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Basic Information Top
Gene Symbol:SRGN ( FLJ12930,MGC9289,PPG,PRG,PRG1 )
Gene Full Name: serglycin
Band: 10q22.1
Quick LinksEntrez ID:5552; OMIM: 177040; Uniprot ID:SRGN_HUMAN; ENSEMBL ID: ENSG00000122862; HGNC ID: 9361
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult216 / 1939121111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma4 / 17475228
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma29 / 82823350
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma9 / 10688384
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia61 / 95842636
liver tumor15 / 96359155
lung tumor37 / 103127358
lymphoma11 / 71755153
non-neoplasia6 / 9725061
normal345 / 3360307102
ovarian tumor4 / 7668252
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites1 / 4001524
bladder0 / 297570 
blood82 / 123478664
bone16 / 71655223
bone marrow21 / 48801430
brain41 / 110098937
cervix0 / 481710 
connective tissue23 / 149255154
ear1 / 1621261
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye11 / 21105452
heart2 / 8962622
intestine4 / 23447217
kidney16 / 21177775
larynx0 / 241450 
liver22 / 207743105
lung100 / 336974296
lymph0 / 442700 
lymph node18 / 91610196
mammary gland4 / 15327126
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary9 / 10205188
pancreas17 / 21481279
parathyroid4 / 20539194
pharynx13 / 41328314
pituitary gland3 / 16585180
placenta26 / 28082592
prostate4 / 18934521
salivary gland1 / 2015549
skin14 / 21057466
spleen5 / 5395292
stomach5 / 9661951
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular203 / 517803920
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201859_at
Cell line Expression level Expression bar
721_B_lymphoblasts8376.25
Adipocyte68.1
AdrenalCortex106.9
Adrenalgland235.55
Amygdala213.15
Appendix249.25
AtrioventricularNode115.4
BDCA4+_DentriticCells7073.15
Bonemarrow8584.3
BronchialEpithelialCells29.1
CD105+_Endothelial1357.8
CD14+_Monocytes8821.1
CD19+_BCells(neg._sel.)815.25
CD33+_Myeloid16696.5
CD34+8327.75
CD4+_Tcells1858.7
CD56+_NKCells10366.85
CD71+_EarlyErythroid139.05
CD8+_Tcells1933.8
CardiacMyocytes890.8
Caudatenucleus80.2
Cerebellum31.75
CerebellumPeduncles43.65
CiliaryGanglion157.75
CingulateCortex53.5
Colorectaladenocarcinoma11.55
DorsalRootGanglion78.6
FetalThyroid45.8
Fetalbrain156.3
Fetalliver178.6
Fetallung1656
GlobusPallidus50.5
Heart85.35
Hypothalamus357.2
Kidney83.35
Leukemia_chronicMyelogenousK-562279.15
Leukemia_promyelocytic-HL-6041.4
Leukemialymphoblastic(MOLT-4)24.1
Liver44.5
Lung1705.7
Lymphnode1546.4
Lymphoma_burkitts(Daudi)60.65
Lymphoma_burkitts(Raji)242
MedullaOblongata41.75
OccipitalLobe76.45
OlfactoryBulb1452.8
Ovary226
Pancreas102.25
PancreaticIslet371.5
ParietalLobe32.45
Pituitary310.6
Placenta780.75
Pons63.3
PrefrontalCortex164.5
Prostate673.3
Salivarygland407.25
SkeletalMuscle92.25
Skin67
SmoothMuscle3276.45
Spinalcord637.8
SubthalamicNucleus58
SuperiorCervicalGanglion76.45
TemporalLobe67.8
Testis53.9
TestisGermCell52.15
TestisIntersitial44.95
TestisLeydigCell53.75
TestisSeminiferousTubule56.1
Thalamus82.85
Thymus778.65
Thyroid669.25
Tongue63.3
Tonsil941.25
Trachea408.3
TrigeminalGanglion192.95
Uterus502.55
UterusCorpus68.4
WholeBlood9434.4
Wholebrain59.2
colon322.65
pineal_day147.42
pineal_night124.32
retina1374.875
small_intestine1310.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P86653
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.25 ± 0.42
Basal Forebrain6.34 ± 0.3
Basal Part of Pons6.6 ± 0.55
Cerebellar Cortex6.29 ± 0.26
Cerebellar Nuclei7.74 ± 0.35
Claustrum6.22 ± 1.17
Epithalamus7.41 ± 0.46
Frontal Lobe6.7 ± 0.49
Globus Pallidus7.89 ± 0.31
Hypothalamus6.71 ± 1.07
Insula6.78 ± 0.28
Limbic Lobe6.5 ± 0.5
Mesencephalon6.82 ± 0.44
Myelencephalon6.81 ± 0.57
Occipital Lobe6.84 ± 0.61
Parietal Lobe6.45 ± 0.5
Pontine Tegmentum6.78 ± 0.48
Striatum7.55 ± 0.47
Subthalamus7.19 ± 0.25
Temporal Lobe6.55 ± 0.38
Thalamus6.85 ± 0.38
White Matter8.08 ± 0.93
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prg1CBCerebellum2.4
4.85
Prg1CTXCerebral cortex0.45
0.65
Prg1HIPHippocampal region0.17
0.25
Prg1HPFHippocampal formation0.15
0.21
Prg1HYHypothalamus0.04
0.06
Prg1LSXLateral septal complex0
0
Prg1MBMidbrain3.23
4.85
Prg1MYMedulla0.16
0.16
Prg1OLFOlfactory bulb0.19
0.24
Prg1PPons0.21
0.37
Prg1PALPallidum0.13
0.15
Prg1RHPRetrohippocampal region0.12
0.12
Prg1sAMYStriatum-like amygdalar nuclei0.16
0.18
Prg1STRStriatum0.04
0.04
Prg1STRdStriatum dorsal region0.03
0.03
Prg1STRvStriatum ventral region0.01
0
Prg1THThalamus0.18
0.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00138490 13 54 66 GPMFELLPGESNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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