AutismKB 2.0

Annotation Detail for DHTKD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DHTKD1 ( DKFZp762M115,KIAA1630,MGC3090 )
Gene Full Name: dehydrogenase E1 and transketolase domain containing 1
Band: 10p14
Quick LinksEntrez ID:55526; OMIM: NA; Uniprot ID:DHTK1_HUMAN; ENSEMBL ID: ENSG00000181192; HGNC ID: 23537
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst8 / 62319128
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult112 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor39 / 94178414
cervical tumor4 / 34366116
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor3 / 17290173
gastrointestinal tumor3 / 11936925
germ cell tumor16 / 26384560
glioma7 / 10688365
head and neck tumor20 / 136302146
kidney tumor2 / 6895929
leukemia9 / 9584293
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal85 / 336030725
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer10 / 10268097
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood9 / 12347872
bone1 / 7165513
bone marrow0 / 488010 
brain17 / 110098915
cervix9 / 48171186
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus3 / 20209148
eye2 / 2110549
heart2 / 8962622
intestine11 / 23447246
kidney20 / 21177794
larynx0 / 241450 
liver10 / 20774348
lung7 / 33697420
lymph0 / 442700 
lymph node5 / 9161054
mammary gland41 / 153271267
mouth19 / 67052283
muscle5 / 10771546
nerve0 / 157680 
ovary4 / 10205139
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta17 / 28082560
prostate9 / 18934547
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach2 / 9661920
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209916_at
Cell line Expression level Expression bar
721_B_lymphoblasts112.5
Adipocyte36.8
AdrenalCortex17.5
Adrenalgland11.1
Amygdala8.5
Appendix18.15
AtrioventricularNode13.3
BDCA4+_DentriticCells166.85
Bonemarrow12.1
BronchialEpithelialCells11.4
CD105+_Endothelial10.8
CD14+_Monocytes12.6
CD19+_BCells(neg._sel.)27.1
CD33+_Myeloid13.45
CD34+20
CD4+_Tcells11
CD56+_NKCells11.2
CD71+_EarlyErythroid10.05
CD8+_Tcells9.6
CardiacMyocytes15.1
Caudatenucleus10.75
Cerebellum9.65
CerebellumPeduncles23.15
CiliaryGanglion7.85
CingulateCortex12.15
Colorectaladenocarcinoma9.5
DorsalRootGanglion12.1
FetalThyroid11.65
Fetalbrain10.55
Fetalliver13.6
Fetallung8.5
GlobusPallidus8.55
Heart15.2
Hypothalamus15.3
Kidney35.3
Leukemia_chronicMyelogenousK-56210.6
Leukemia_promyelocytic-HL-6010.2
Leukemialymphoblastic(MOLT-4)12.1
Liver166.85
Lung11.8
Lymphnode9.15
Lymphoma_burkitts(Daudi)14.8
Lymphoma_burkitts(Raji)41.65
MedullaOblongata15.4
OccipitalLobe10.8
OlfactoryBulb12.5
Ovary9.3
Pancreas12.55
PancreaticIslet16.75
ParietalLobe22.65
Pituitary14.35
Placenta10.6
Pons19.2
PrefrontalCortex13.2
Prostate20.1
Salivarygland9.65
SkeletalMuscle29.6
Skin11.5
SmoothMuscle12.85
Spinalcord11.5
SubthalamicNucleus12.55
SuperiorCervicalGanglion13.8
TemporalLobe12.75
Testis7.9
TestisGermCell18
TestisIntersitial8.8
TestisLeydigCell11.1
TestisSeminiferousTubule11
Thalamus10.95
Thymus12.6
Thyroid12.1
Tongue15.8
Tonsil16.55
Trachea9.75
TrigeminalGanglion16.25
Uterus10.9
UterusCorpus34.45
WholeBlood11.4
Wholebrain7.9
colon10.55
pineal_day14.92
pineal_night19.24
retina17.7
small_intestine9.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P12601
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.04 ± 0.56
Basal Forebrain5.48 ± 0.19
Basal Part of Pons4.84 ± 0.47
Cerebellar Cortex5.53 ± 0.27
Cerebellar Nuclei4.9 ± 0.37
Claustrum5 ± 0.51
Epithalamus5.2 ± 0.37
Frontal Lobe4.96 ± 0.45
Globus Pallidus5.61 ± 0.52
Hypothalamus5.19 ± 0.42
Insula4.88 ± 0.59
Limbic Lobe4.93 ± 0.55
Mesencephalon5.04 ± 0.55
Myelencephalon5.13 ± 0.47
Occipital Lobe5.16 ± 0.35
Parietal Lobe5.13 ± 0.45
Pontine Tegmentum5.07 ± 0.48
Striatum5.04 ± 0.56
Subthalamus4.83 ± 0.2
Temporal Lobe5.03 ± 0.39
Thalamus5.32 ± 0.48
White Matter6.43 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dhtkd1CBCerebellum6.38
8.69
Dhtkd1CTXCerebral cortex5.84
2.96
Dhtkd1HIPHippocampal region2.25
2.04
Dhtkd1HPFHippocampal formation2.3
1.77
Dhtkd1HYHypothalamus1.56
1.08
Dhtkd1LSXLateral septal complex5.19
6.65
Dhtkd1MBMidbrain3.55
2.55
Dhtkd1MYMedulla9.67
8.39
Dhtkd1OLFOlfactory bulb10.08
6.49
Dhtkd1PPons6.84
4.71
Dhtkd1PALPallidum3.66
2.43
Dhtkd1RHPRetrohippocampal region2.4
1.38
Dhtkd1sAMYStriatum-like amygdalar nuclei1.76
0.69
Dhtkd1STRStriatum4.07
2.58
Dhtkd1STRdStriatum dorsal region3.47
2.49
Dhtkd1STRvStriatum ventral region6.53
2.57
Dhtkd1THThalamus3.71
3.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010898 11 59 69 LVTVYCEHGHK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved