AutismKB 2.0

Annotation Detail for TTC27


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Basic Information Top
Gene Symbol:TTC27 ( FLJ20272 )
Gene Full Name: tetratricopeptide repeat domain 27
Band: 2p22.3
Quick LinksEntrez ID:55622; OMIM: NA; Uniprot ID:TTC27_HUMAN; ENSEMBL ID: ENSG00000018699; HGNC ID: 25986
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus36 / 56401263
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult88 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma12 / 82823144
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor11 / 11936992
germ cell tumor17 / 26384564
glioma1 / 1068839
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia10 / 95842104
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal112 / 336030733
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder2 / 2975767
blood8 / 12347864
bone11 / 71655153
bone marrow12 / 48801245
brain27 / 110098924
cervix2 / 4817141
connective tissue9 / 14925560
ear2 / 16212123
embryonic tissue8 / 21572237
esophagus3 / 20209148
eye8 / 21105437
heart2 / 8962622
intestine13 / 23447255
kidney13 / 21177761
larynx3 / 24145124
liver6 / 20774328
lung6 / 33697417
lymph1 / 4427022
lymph node4 / 9161043
mammary gland4 / 15327126
mouth4 / 6705259
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate5 / 18934526
salivary gland0 / 201550 
skin4 / 21057418
spleen3 / 5395255
stomach17 / 96619175
testis21 / 33044263
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus9 / 23287838
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218710_at
Cell line Expression level Expression bar
721_B_lymphoblasts33.7
Adipocyte6
AdrenalCortex6.3
Adrenalgland5.9
Amygdala5.9
Appendix6.45
AtrioventricularNode5.15
BDCA4+_DentriticCells15.1
Bonemarrow6.25
BronchialEpithelialCells7.2
CD105+_Endothelial16
CD14+_Monocytes6.85
CD19+_BCells(neg._sel.)41.15
CD33+_Myeloid10.15
CD34+22.95
CD4+_Tcells12.85
CD56+_NKCells8.45
CD71+_EarlyErythroid5.65
CD8+_Tcells13.85
CardiacMyocytes11.75
Caudatenucleus5.5
Cerebellum4.9
CerebellumPeduncles6.9
CiliaryGanglion4.65
CingulateCortex6.95
Colorectaladenocarcinoma8.35
DorsalRootGanglion4.95
FetalThyroid7.25
Fetalbrain7.45
Fetalliver5.6
Fetallung6
GlobusPallidus4.5
Heart8.55
Hypothalamus6.05
Kidney5.2
Leukemia_chronicMyelogenousK-56232.25
Leukemia_promyelocytic-HL-6020.7
Leukemialymphoblastic(MOLT-4)6.2
Liver8.2
Lung6.7
Lymphnode5.35
Lymphoma_burkitts(Daudi)12.15
Lymphoma_burkitts(Raji)8.95
MedullaOblongata5.5
OccipitalLobe5.65
OlfactoryBulb4.65
Ovary4.25
Pancreas5.2
PancreaticIslet7.15
ParietalLobe6.7
Pituitary7.6
Placenta7.35
Pons6.2
PrefrontalCortex6.75
Prostate7.3
Salivarygland5.1
SkeletalMuscle7.75
Skin6.65
SmoothMuscle8
Spinalcord7.4
SubthalamicNucleus5.65
SuperiorCervicalGanglion7.65
TemporalLobe5.75
Testis7.1
TestisGermCell11.25
TestisIntersitial9.95
TestisLeydigCell6.85
TestisSeminiferousTubule7.15
Thalamus6.3
Thymus4.75
Thyroid7.55
Tongue6.4
Tonsil8.45
Trachea5.1
TrigeminalGanglion6.4
Uterus6.4
UterusCorpus5.65
WholeBlood6.75
Wholebrain4.85
colon6.05
pineal_day7.04
pineal_night6.74
retina7.1
small_intestine5.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_743_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.19 ± 0.44
Basal Forebrain4.4 ± 0.44
Basal Part of Pons4.72 ± 0.24
Cerebellar Cortex4.67 ± 0.25
Cerebellar Nuclei4.21 ± 0.43
Claustrum4.25 ± 0.59
Epithalamus4.42 ± 0.37
Frontal Lobe4.52 ± 0.38
Globus Pallidus4.58 ± 0.66
Hypothalamus4.49 ± 0.56
Insula4.42 ± 0.38
Limbic Lobe4.44 ± 0.4
Mesencephalon4.44 ± 0.39
Myelencephalon4.41 ± 0.42
Occipital Lobe4.3 ± 0.33
Parietal Lobe4.47 ± 0.41
Pontine Tegmentum4.53 ± 0.42
Striatum4.19 ± 0.43
Subthalamus4.3 ± 0.4
Temporal Lobe4.48 ± 0.41
Thalamus4.48 ± 0.43
White Matter5.43 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ttc27CBCerebellum2.56
3.01
Ttc27CTXCerebral cortex1.84
1.71
Ttc27HIPHippocampal region5.1
5.14
Ttc27HPFHippocampal formation3.93
3.81
Ttc27HYHypothalamus0.27
0.38
Ttc27LSXLateral septal complex0.09
0.08
Ttc27MBMidbrain0.99
1.36
Ttc27MYMedulla2.47
3.12
Ttc27OLFOlfactory bulb1.38
2.03
Ttc27PPons2.68
3.63
Ttc27PALPallidum0.32
0.36
Ttc27RHPRetrohippocampal region2.29
2.19
Ttc27sAMYStriatum-like amygdalar nuclei0.33
0.24
Ttc27STRStriatum0.25
0.26
Ttc27STRdStriatum dorsal region0.27
0.3
Ttc27STRvStriatum ventral region0.22
0.21
Ttc27THThalamus1.19
1.03
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00066063 22 292 313 EGDVLSNCEFTPAPTPQEHLTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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