AutismKB 2.0

Annotation Detail for DEPDC1


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Basic Information Top
Gene Symbol:DEPDC1 ( DEP.8,DEPDC1-V2,DEPDC1A,FLJ20354,SDP35 )
Gene Full Name: DEP domain containing 1
Band: 1p31.3
Quick LinksEntrez ID:55635; OMIM: 612002; Uniprot ID:DEP1A_HUMAN; ENSEMBL ID: ENSG00000024526; HGNC ID: 22949
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus15 / 56401226
neonate2 / 3109764
infant2 / 2362084
juvenile2 / 5555635
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor8 / 17290462
gastrointestinal tumor4 / 11936933
germ cell tumor18 / 26384568
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal50 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer5 / 10268048
retinoblastoma5 / 46356107
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow3 / 4880161
brain13 / 110098911
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus8 / 20209395
eye7 / 21105433
heart0 / 896260 
intestine4 / 23447217
kidney3 / 21177714
larynx0 / 241450 
liver6 / 20774328
lung3 / 3369748
lymph1 / 4427022
lymph node7 / 9161076
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate5 / 18934526
salivary gland1 / 2015549
skin4 / 21057418
spleen0 / 539520 
stomach1 / 9661910
testis26 / 33044278
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220295_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.9
Adipocyte3.15
AdrenalCortex3.25
Adrenalgland2.65
Amygdala3.25
Appendix3.3
AtrioventricularNode2.5
BDCA4+_DentriticCells3.5
Bonemarrow3.05
BronchialEpithelialCells3.15
CD105+_Endothelial44.35
CD14+_Monocytes3.4
CD19+_BCells(neg._sel.)3.4
CD33+_Myeloid4.1
CD34+6.05
CD4+_Tcells3.45
CD56+_NKCells3.8
CD71+_EarlyErythroid19.05
CD8+_Tcells3.1
CardiacMyocytes7.95
Caudatenucleus2.8
Cerebellum2.5
CerebellumPeduncles3.5
CiliaryGanglion2.25
CingulateCortex3.15
Colorectaladenocarcinoma3.15
DorsalRootGanglion2.5
FetalThyroid3.1
Fetalbrain3.15
Fetalliver3.4
Fetallung2.65
GlobusPallidus2.3
Heart4
Hypothalamus3.4
Kidney2.5
Leukemia_chronicMyelogenousK-5622.85
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)2.55
Liver4.15
Lung3.5
Lymphnode2.7
Lymphoma_burkitts(Daudi)4
Lymphoma_burkitts(Raji)4.4
MedullaOblongata2.9
OccipitalLobe2.8
OlfactoryBulb2.5
Ovary2.05
Pancreas2.5
PancreaticIslet3.35
ParietalLobe3.3
Pituitary3.7
Placenta3.3
Pons3
PrefrontalCortex3.9
Prostate3.7
Salivarygland2.5
SkeletalMuscle3.65
Skin2.5
SmoothMuscle3.6
Spinalcord3.35
SubthalamicNucleus2.85
SuperiorCervicalGanglion4.05
TemporalLobe2.85
Testis2.7
TestisGermCell3.1
TestisIntersitial2.85
TestisLeydigCell4.1
TestisSeminiferousTubule3.4
Thalamus3.2
Thymus2.5
Thyroid3.95
Tongue3.1
Tonsil3.05
Trachea2.6
TrigeminalGanglion3.1
Uterus2.6
UterusCorpus2.8
WholeBlood3.4
Wholebrain2.7
colon3.15
pineal_day3.94
pineal_night3.84
retina3.8
small_intestine3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P200310
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.35 ± 0.33
Basal Forebrain6.44 ± 0.21
Basal Part of Pons6.38 ± 0.31
Cerebellar Cortex6.77 ± 0.13
Cerebellar Nuclei6.59 ± 0.19
Claustrum6.46 ± 0.48
Epithalamus5.86 ± 0.28
Frontal Lobe6.36 ± 0.35
Globus Pallidus6.54 ± 0.38
Hypothalamus6.2 ± 0.66
Insula6.28 ± 0.21
Limbic Lobe6.42 ± 0.4
Mesencephalon6.37 ± 0.49
Myelencephalon6.37 ± 0.47
Occipital Lobe6.69 ± 0.35
Parietal Lobe6.45 ± 0.35
Pontine Tegmentum6.41 ± 0.4
Striatum6.11 ± 0.45
Subthalamus6.47 ± 0.38
Temporal Lobe6.4 ± 0.32
Thalamus6.39 ± 0.36
White Matter8.05 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Depdc1aCBCerebellum1.46
2.65
Depdc1aCTXCerebral cortex1.52
1.47
Depdc1aHIPHippocampal region1.39
1.34
Depdc1aHPFHippocampal formation0.96
1.01
Depdc1aHYHypothalamus0.05
0.04
Depdc1aLSXLateral septal complex0.4
0.42
Depdc1aMBMidbrain1.49
2.5
Depdc1aMYMedulla0.61
1.32
Depdc1aOLFOlfactory bulb0.81
2.67
Depdc1aPPons0.86
1.34
Depdc1aPALPallidum0.08
0.07
Depdc1aRHPRetrohippocampal region0.22
0.58
Depdc1asAMYStriatum-like amygdalar nuclei0.06
0.14
Depdc1aSTRStriatum0.31
0.39
Depdc1aSTRdStriatum dorsal region0.35
0.45
Depdc1aSTRvStriatum ventral region0.23
0.29
Depdc1aTHThalamus0.35
0.38
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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