AutismKB 2.0

Annotation Detail for DENND4C


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Basic Information Top
Gene Symbol:DENND4C ( C9orf55,C9orf55B,DKFZp686I09113,FLJ20686,bA513M16.3 )
Gene Full Name: DENN/MADD domain containing 4C
Band: 9p22.1
Quick LinksEntrez ID:55667; OMIM: NA; Uniprot ID:DEN4C_HUMAN; ENSEMBL ID: ENSG00000137145; HGNC ID: 26079
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst7 / 62319112
fetus33 / 56401258
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal128 / 336030738
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites3 / 4001574
bladder3 / 29757100
blood4 / 12347832
bone0 / 716550 
bone marrow0 / 488010 
brain33 / 110098929
cervix1 / 4817120
connective tissue5 / 14925533
ear3 / 16212185
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye4 / 21105418
heart2 / 8962622
intestine7 / 23447229
kidney8 / 21177737
larynx0 / 241450 
liver3 / 20774314
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland10 / 15327165
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary3 / 10205129
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta14 / 28082549
prostate11 / 18934558
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis16 / 33044248
thymus5 / 8113161
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord1 / 1368073
uterus13 / 23287855
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205684_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts58.1
Adipocyte29.8
AdrenalCortex36.05
Adrenalgland24.6
Amygdala24.7
Appendix44.45
AtrioventricularNode32.3
BDCA4+_DentriticCells29.35
Bonemarrow31.55
BronchialEpithelialCells24.45
CD105+_Endothelial26.3
CD14+_Monocytes43.35
CD19+_BCells(neg._sel.)30.85
CD33+_Myeloid34.65
CD34+31.75
CD4+_Tcells90.05
CD56+_NKCells81.35
CD71+_EarlyErythroid28.8
CD8+_Tcells82.65
CardiacMyocytes36.8
Caudatenucleus25.4
Cerebellum21.55
CerebellumPeduncles40.8
CiliaryGanglion35.4
CingulateCortex34.9
Colorectaladenocarcinoma26.05
DorsalRootGanglion41.95
FetalThyroid32.65
Fetalbrain29.4
Fetalliver24.45
Fetallung23.6
GlobusPallidus28.55
Heart43
Hypothalamus28.2
Kidney26.15
Leukemia_chronicMyelogenousK-56226.4
Leukemia_promyelocytic-HL-6028.3
Leukemialymphoblastic(MOLT-4)21.2
Liver45.2
Lung31
Lymphnode24.6
Lymphoma_burkitts(Daudi)38.05
Lymphoma_burkitts(Raji)47.75
MedullaOblongata26.6
OccipitalLobe26.1
OlfactoryBulb35.25
Ovary27.35
Pancreas30.75
PancreaticIslet41.2
ParietalLobe33.45
Pituitary39.8
Placenta25.55
Pons47.05
PrefrontalCortex29.85
Prostate42.45
Salivarygland29.65
SkeletalMuscle67.3
Skin48
SmoothMuscle32.6
Spinalcord28.75
SubthalamicNucleus34.55
SuperiorCervicalGanglion65.8
TemporalLobe28.15
Testis22.35
TestisGermCell31.25
TestisIntersitial25.75
TestisLeydigCell30.8
TestisSeminiferousTubule28.5
Thalamus30.4
Thymus18.75
Thyroid45.45
Tongue45.25
Tonsil32.1
Trachea24.9
TrigeminalGanglion54.7
Uterus48.1
UterusCorpus37.5
WholeBlood29
Wholebrain15.95
colon44.15
pineal_day43.94
pineal_night39.2
retina33.175
small_intestine31.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5413_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.69 ± 0.78
Basal Forebrain3.35 ± 0.56
Basal Part of Pons3.38 ± 0.65
Cerebellar Cortex3.94 ± 0.28
Cerebellar Nuclei3.58 ± 0.46
Claustrum3.41 ± 0.59
Epithalamus3.81 ± 0.57
Frontal Lobe3.39 ± 0.58
Globus Pallidus3.57 ± 0.66
Hypothalamus3.34 ± 0.64
Insula3.07 ± 0.57
Limbic Lobe3.33 ± 0.57
Mesencephalon3.49 ± 0.63
Myelencephalon3.44 ± 0.59
Occipital Lobe3.75 ± 0.59
Parietal Lobe3.47 ± 0.53
Pontine Tegmentum3.53 ± 0.57
Striatum3.74 ± 0.67
Subthalamus3.23 ± 0.43
Temporal Lobe3.25 ± 0.61
Thalamus3.48 ± 0.56
White Matter3.56 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
1700065A05RikCBCerebellum5.48
6.56
1700065A05RikCTXCerebral cortex4.08
2.87
1700065A05RikHIPHippocampal region1.17
1.24
1700065A05RikHPFHippocampal formation1.11
1.06
1700065A05RikHYHypothalamus0.25
0.22
1700065A05RikLSXLateral septal complex0.7
0.69
1700065A05RikMBMidbrain0.69
0.87
1700065A05RikMYMedulla2.59
2.91
1700065A05RikOLFOlfactory bulb4.18
3.25
1700065A05RikPPons0.92
1.03
1700065A05RikPALPallidum1.3
0.96
1700065A05RikRHPRetrohippocampal region1.05
0.85
1700065A05RiksAMYStriatum-like amygdalar nuclei0.89
0.9
1700065A05RikSTRStriatum3.85
2.61
1700065A05RikSTRdStriatum dorsal region5.19
3.55
1700065A05RikSTRvStriatum ventral region1.89
1.14
1700065A05RikTHThalamus1.3
1.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DEN4C_HUMAN_1026 14 1026 1039 ESGMTTAFIHALER PRIDE
DEN4C_HUMAN_1114 9 1114 1122 LDNILSGPK PRIDE
DEN4C_HUMAN_1132 8 1132 1139 QAATVASK PRIDE
DEN4C_HUMAN_1546 9 1546 1554 MKPGMKRQR PRIDE
DEN4C_HUMAN_1547 8 1547 1554 EPLYVSWR PRIDE
DEN4C_HUMAN_356 10 356 365 ATAADSLFDR PRIDE
DEN4C_HUMAN_427 6 427 432 LKLFDR PRIDE
DEN4C_HUMAN_496 9 496 504 HPTGNSITK PRIDE
DEN4C_HUMAN_537 19 537 555 CLFSHCYSLWFICLPAYVR PRIDE
DEN4C_HUMAN_563 11 563 573 ALQQAYDVLIK PRIDE
DEN4C_HUMAN_628 12 628 639 VVLESPWPSSTR PRIDE
DEN4C_HUMAN_640 8 640 647 SGIFLWTK PRIDE
DEN4C_HUMAN_751 11 751 761 VPSGIFDVNSR PRIDE
DEN4C_HUMAN_843 10 843 852 ILTAALTCPK PRIDE
DEN4C_HUMAN_92 7 92 98 FLMFIYK PRIDE
DEN4C_HUMAN_959 21 959 979 EDVETGLDPLSLLATECTGGK PRIDE
DEN4C_HUMAN_980 15 980 994 TPDSEDKLFSPVIAR PRIDE
DEN4C_HUMAN_995 13 995 1007 NLADEIESYMNLK PRIDE
PAp00095677 21 959 979 EDVETGLDPLSLLATECTGGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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