AutismKB 2.0

Annotation Detail for FRMD4A


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Basic Information Top
Gene Symbol:FRMD4A ( FLJ10210,FRMD4,KIAA1294,bA295P9.4 )
Gene Full Name: FERM domain containing 4A
Band: 10p13
Quick LinksEntrez ID:55691; OMIM: NA; Uniprot ID:FRM4A_HUMAN; ENSEMBL ID: ENSG00000151474; HGNC ID: 25491
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst0 / 623190 
fetus54 / 56401295
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult74 / 193912138
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult4 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma4 / 10688337
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal155 / 336030746
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor9 / 12494972
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal7 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain41 / 110098937
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye14 / 21105466
heart2 / 8962622
intestine6 / 23447225
kidney8 / 21177737
larynx2 / 2414582
liver2 / 2077439
lung15 / 33697444
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth4 / 6705259
muscle3 / 10771527
nerve2 / 15768126
ovary3 / 10205129
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate8 / 18934542
salivary gland0 / 201550 
skin15 / 21057471
spleen5 / 5395292
stomach1 / 9661910
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208476_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts31.75
Adipocyte4.55
AdrenalCortex4.8
Adrenalgland3.9
Amygdala4.75
Appendix4.55
AtrioventricularNode3.8
BDCA4+_DentriticCells4.75
Bonemarrow4.5
BronchialEpithelialCells4.5
CD105+_Endothelial4.55
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid5.8
CD34+5.6
CD4+_Tcells4.95
CD56+_NKCells5.2
CD71+_EarlyErythroid11
CD8+_Tcells4.4
CardiacMyocytes6
Caudatenucleus4.1
Cerebellum3.65
CerebellumPeduncles5.2
CiliaryGanglion3.25
CingulateCortex4.65
Colorectaladenocarcinoma4.55
DorsalRootGanglion3.55
FetalThyroid4.45
Fetalbrain4.55
Fetalliver4
Fetallung3.75
GlobusPallidus3.45
Heart5.95
Hypothalamus4.9
Kidney3.7
Leukemia_chronicMyelogenousK-5624.1
Leukemia_promyelocytic-HL-604.05
Leukemialymphoblastic(MOLT-4)3.65
Liver6.15
Lung5.05
Lymphnode3.9
Lymphoma_burkitts(Daudi)5.8
Lymphoma_burkitts(Raji)6.45
MedullaOblongata4.15
OccipitalLobe4.15
OlfactoryBulb4.7
Ovary3.05
Pancreas3.7
PancreaticIslet4.9
ParietalLobe4.9
Pituitary5.3
Placenta4.75
Pons4.35
PrefrontalCortex7.5
Prostate9.45
Salivarygland3.6
SkeletalMuscle5.35
Skin3.75
SmoothMuscle5.2
Spinalcord4.8
SubthalamicNucleus4.2
SuperiorCervicalGanglion5.2
TemporalLobe4.25
Testis3.9
TestisGermCell3.8
TestisIntersitial3.8
TestisLeydigCell4.5
TestisSeminiferousTubule3.9
Thalamus4.65
Thymus3.6
Thyroid5.7
Tongue4.6
Tonsil4.45
Trachea3.8
TrigeminalGanglion4.6
Uterus3.85
UterusCorpus4.1
WholeBlood4.9
Wholebrain3.85
colon4.6
pineal_day5.74
pineal_night5.6
retina5.55
small_intestine4.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P43959
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.13 ± 0.65
Basal Forebrain4.17 ± 0.34
Basal Part of Pons4.36 ± 0.58
Cerebellar Cortex3.96 ± 0.74
Cerebellar Nuclei4.38 ± 0.61
Claustrum4.36 ± 1.02
Epithalamus3.87 ± 0.6
Frontal Lobe4.41 ± 0.85
Globus Pallidus4.71 ± 0.61
Hypothalamus3.87 ± 0.95
Insula4.17 ± 1.06
Limbic Lobe4.38 ± 0.68
Mesencephalon4.12 ± 0.61
Myelencephalon4.28 ± 0.73
Occipital Lobe4.21 ± 0.79
Parietal Lobe4.21 ± 0.64
Pontine Tegmentum4.29 ± 0.76
Striatum4.49 ± 0.68
Subthalamus3.7 ± 0.31
Temporal Lobe4.32 ± 0.73
Thalamus4.33 ± 0.6
White Matter3.92 ± 1.05
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018