AutismKB 2.0

Annotation Detail for POLR3B


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Basic Information Top
Gene Symbol:POLR3B ( C128,DKFZp686B10117,FLJ10388,RPC2 )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide B
Band: 12q23.3
Quick LinksEntrez ID:55703; OMIM: NA; Uniprot ID:RPC2_HUMAN; ENSEMBL ID: ENSG00000013503; HGNC ID: 30348
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult68 / 193912135
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult1 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma0 / 828230 
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor16 / 26384560
glioma4 / 10688337
head and neck tumor9 / 13630266
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal97 / 336030728
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal2 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow1 / 4880120
brain41 / 110098937
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine11 / 23447246
kidney7 / 21177733
larynx0 / 241450 
liver5 / 20774324
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth6 / 6705289
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta12 / 28082542
prostate2 / 18934510
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach1 / 9661910
testis36 / 330442108
thymus2 / 8113124
thyroid2 / 4747342
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord0 / 136800 
uterus5 / 23287821
vascular2 / 5178038
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219459_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.15
Adipocyte3.9
AdrenalCortex4.1
Adrenalgland3.25
Amygdala4.15
Appendix5.15
AtrioventricularNode2.95
BDCA4+_DentriticCells4.35
Bonemarrow3.8
BronchialEpithelialCells3.85
CD105+_Endothelial4.3
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)4.15
CD33+_Myeloid5.05
CD34+5.05
CD4+_Tcells4.3
CD56+_NKCells4.85
CD71+_EarlyErythroid3.65
CD8+_Tcells3.85
CardiacMyocytes4.9
Caudatenucleus3.6
Cerebellum3.15
CerebellumPeduncles4.4
CiliaryGanglion2.7
CingulateCortex3.95
Colorectaladenocarcinoma3.9
DorsalRootGanglion2.95
FetalThyroid3.8
Fetalbrain3.95
Fetalliver3.4
Fetallung3.25
GlobusPallidus2.85
Heart4.9
Hypothalamus4.25
Kidney3.15
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-603.5
Leukemialymphoblastic(MOLT-4)3.15
Liver5.1
Lung4.3
Lymphnode3.35
Lymphoma_burkitts(Daudi)5.35
Lymphoma_burkitts(Raji)5.4
MedullaOblongata3.55
OccipitalLobe3.5
OlfactoryBulb3.1
Ovary2.6
Pancreas3.1
PancreaticIslet4.15
ParietalLobe4.05
Pituitary4.6
Placenta4.3
Pons3.7
PrefrontalCortex4.9
Prostate4.55
Salivarygland3.1
SkeletalMuscle4.55
Skin3
SmoothMuscle4.35
Spinalcord4.2
SubthalamicNucleus3.55
SuperiorCervicalGanglion4.7
TemporalLobe3.55
Testis3.35
TestisGermCell3.3
TestisIntersitial3.25
TestisLeydigCell3.85
TestisSeminiferousTubule3.4
Thalamus3.9
Thymus3.1
Thyroid4.9
Tongue3.8
Tonsil3.8
Trachea3.3
TrigeminalGanglion3.9
Uterus3.2
UterusCorpus3.45
WholeBlood4.3
Wholebrain3.3
colon3.95
pineal_day4.9
pineal_night4.84
retina4.75
small_intestine3.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P87732
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.17 ± 0.45
Basal Forebrain5.4 ± 0.42
Basal Part of Pons5.7 ± 0.26
Cerebellar Cortex5.27 ± 0.22
Cerebellar Nuclei5.7 ± 0.28
Claustrum5.41 ± 0.52
Epithalamus5.56 ± 0.41
Frontal Lobe5.58 ± 0.35
Globus Pallidus4.91 ± 0.18
Hypothalamus5.63 ± 0.38
Insula5.62 ± 0.27
Limbic Lobe5.16 ± 0.5
Mesencephalon5.45 ± 0.42
Myelencephalon5.38 ± 0.47
Occipital Lobe5.13 ± 0.55
Parietal Lobe5.54 ± 0.45
Pontine Tegmentum5.48 ± 0.47
Striatum5.66 ± 0.47
Subthalamus5.51 ± 1
Temporal Lobe5.55 ± 0.33
Thalamus5.46 ± 0.37
White Matter4.78 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Polr3bCBCerebellum100
100
Polr3bCTXCerebral cortex100
100
Polr3bHIPHippocampal region100
100
Polr3bHPFHippocampal formation100
100
Polr3bHYHypothalamus100
100
Polr3bLSXLateral septal complex100
100
Polr3bMBMidbrain100
100
Polr3bMYMedulla100
100
Polr3bOLFOlfactory bulb100
100
Polr3bPPons100
100
Polr3bPALPallidum100
100
Polr3bRHPRetrohippocampal region100
100
Polr3bsAMYStriatum-like amygdalar nuclei100
100
Polr3bSTRStriatum100
100
Polr3bSTRdStriatum dorsal region100
100
Polr3bSTRvStriatum ventral region100
100
Polr3bTHThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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