AutismKB 2.0

Annotation Detail for NECAP2


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Basic Information Top
Gene Symbol:NECAP2 ( FLJ10420 )
Gene Full Name: NECAP endocytosis associated 2
Band: 1p36.13
Quick LinksEntrez ID:55707; OMIM: 611624; Uniprot ID:NECP2_HUMAN; ENSEMBL ID: ENSG00000157191; HGNC ID: 25528
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus36 / 56401263
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult210 / 1939121108
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor6 / 9417863
cervical tumor8 / 34366232
chondrosarcoma21 / 82823253
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor11 / 11936992
germ cell tumor18 / 26384568
glioma12 / 106883112
head and neck tumor16 / 136302117
kidney tumor5 / 6895972
leukemia12 / 95842125
liver tumor1 / 9635910
lung tumor6 / 10312758
lymphoma8 / 71755111
non-neoplasia10 / 97250102
normal276 / 336030782
ovarian tumor2 / 7668226
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites3 / 4001574
bladder2 / 2975767
blood18 / 123478145
bone8 / 71655111
bone marrow10 / 48801204
brain69 / 110098962
cervix10 / 48171207
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye11 / 21105452
heart15 / 89626167
intestine27 / 234472115
kidney12 / 21177756
larynx0 / 241450 
liver2 / 2077439
lung39 / 336974115
lymph4 / 4427090
lymph node7 / 9161076
mammary gland9 / 15327158
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary7 / 10205168
pancreas23 / 214812107
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta55 / 280825195
prostate7 / 18934536
salivary gland9 / 20155446
skin11 / 21057452
spleen6 / 53952111
stomach5 / 9661951
testis38 / 330442114
thymus6 / 8113173
thyroid2 / 4747342
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord5 / 13680365
uterus25 / 232878107
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220731_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts171.15
Adipocyte18.25
AdrenalCortex13.7
Adrenalgland18.4
Amygdala11.1
Appendix10.75
AtrioventricularNode7.95
BDCA4+_DentriticCells216.65
Bonemarrow25.85
BronchialEpithelialCells55.5
CD105+_Endothelial184
CD14+_Monocytes407.5
CD19+_BCells(neg._sel.)298.1
CD33+_Myeloid302.55
CD34+124.3
CD4+_Tcells366.65
CD56+_NKCells334.5
CD71+_EarlyErythroid91
CD8+_Tcells303.8
CardiacMyocytes59.9
Caudatenucleus8.6
Cerebellum9.95
CerebellumPeduncles8.2
CiliaryGanglion6.2
CingulateCortex11.2
Colorectaladenocarcinoma20.55
DorsalRootGanglion7.05
FetalThyroid16.95
Fetalbrain13.6
Fetalliver14.15
Fetallung69.4
GlobusPallidus6.05
Heart16.7
Hypothalamus17.1
Kidney11.6
Leukemia_chronicMyelogenousK-56227.5
Leukemia_promyelocytic-HL-6051.2
Leukemialymphoblastic(MOLT-4)27.85
Liver21.95
Lung155.45
Lymphnode73.75
Lymphoma_burkitts(Daudi)30.95
Lymphoma_burkitts(Raji)185.4
MedullaOblongata7.6
OccipitalLobe11.3
OlfactoryBulb13.5
Ovary8.9
Pancreas11.4
PancreaticIslet20.95
ParietalLobe9.3
Pituitary19.25
Placenta147.45
Pons8.4
PrefrontalCortex14.2
Prostate25.65
Salivarygland13.8
SkeletalMuscle14.75
Skin9.8
SmoothMuscle128.75
Spinalcord26.8
SubthalamicNucleus9.95
SuperiorCervicalGanglion12.4
TemporalLobe9.25
Testis52.1
TestisGermCell47.7
TestisIntersitial16.25
TestisLeydigCell13.2
TestisSeminiferousTubule27.05
Thalamus13.3
Thymus60.65
Thyroid24.8
Tongue11.3
Tonsil37.6
Trachea13.9
TrigeminalGanglion9.6
Uterus13.7
UterusCorpus14.95
WholeBlood139
Wholebrain11.95
colon16.5
pineal_day15.46
pineal_night15.54
retina37.875
small_intestine15.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P302332
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.22 ± 0.85
Basal Forebrain5.53 ± 0.45
Basal Part of Pons4.85 ± 0.44
Cerebellar Cortex4.94 ± 0.37
Cerebellar Nuclei5.84 ± 0.55
Claustrum5.79 ± 0.56
Epithalamus5.86 ± 0.65
Frontal Lobe5.04 ± 0.64
Globus Pallidus6.62 ± 0.37
Hypothalamus5.06 ± 0.83
Insula4.87 ± 0.56
Limbic Lobe5.06 ± 0.65
Mesencephalon5.45 ± 0.64
Myelencephalon5.34 ± 0.61
Occipital Lobe5.25 ± 0.63
Parietal Lobe5.21 ± 0.71
Pontine Tegmentum5.35 ± 0.53
Striatum5.63 ± 0.58
Subthalamus5.35 ± 0.14
Temporal Lobe5.12 ± 0.51
Thalamus5.43 ± 0.51
White Matter7.05 ± 0.55
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NECP2_HUMAN_176 19 176 194 VRPASTGGLSLLPPPPGGK PRIDE
NECP2_HUMAN_31 14 31 44 AAEWQLDQPSWSGR PRIDE
PAp00062898 14 32 45 AAEWQLDQPSWSGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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