AutismKB 2.0

Annotation Detail for POLR3E


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:POLR3E ( RPC5,SIN )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Band: 16p12.2
Quick LinksEntrez ID:55718; OMIM: NA; Uniprot ID:RPC5_HUMAN; ENSEMBL ID: ENSG00000058600; HGNC ID: 30347
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst5 / 6231980
fetus52 / 56401292
neonate3 / 3109796
infant2 / 2362084
juvenile12 / 55556215
adult138 / 193912171
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor11 / 94178116
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor16 / 114246140
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor33 / 263845125
glioma14 / 106883130
head and neck tumor23 / 136302168
kidney tumor4 / 6895958
leukemia14 / 95842146
liver tumor13 / 96359134
lung tumor7 / 10312767
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal228 / 336030767
ovarian tumor9 / 76682117
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS14 / 125680111
prostate cancer11 / 102680107
retinoblastoma6 / 46356129
skin tumor9 / 12494972
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites2 / 4001549
bladder2 / 2975767
blood8 / 12347864
bone6 / 7165583
bone marrow2 / 4880140
brain109 / 110098999
cervix3 / 4817162
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye12 / 21105456
heart8 / 8962689
intestine24 / 234472102
kidney9 / 21177742
larynx2 / 2414582
liver18 / 20774386
lung27 / 33697480
lymph2 / 4427045
lymph node15 / 91610163
mammary gland17 / 153271110
mouth20 / 67052298
muscle1 / 1077159
nerve1 / 1576863
ovary11 / 102051107
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate15 / 18934579
salivary gland0 / 201550 
skin17 / 21057480
spleen5 / 5395292
stomach9 / 9661993
testis32 / 33044296
thymus10 / 81131123
thyroid6 / 47473126
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus16 / 23287868
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218016_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts119.05
Adipocyte16.55
AdrenalCortex37.35
Adrenalgland20.6
Amygdala24.8
Appendix11.15
AtrioventricularNode9.7
BDCA4+_DentriticCells96.25
Bonemarrow9.5
BronchialEpithelialCells46.05
CD105+_Endothelial170.2
CD14+_Monocytes23.35
CD19+_BCells(neg._sel.)71.65
CD33+_Myeloid37.1
CD34+169.2
CD4+_Tcells132.5
CD56+_NKCells86
CD71+_EarlyErythroid13.5
CD8+_Tcells128.95
CardiacMyocytes16.7
Caudatenucleus15.3
Cerebellum14.6
CerebellumPeduncles27.05
CiliaryGanglion9.45
CingulateCortex13
Colorectaladenocarcinoma23.45
DorsalRootGanglion6.6
FetalThyroid38.9
Fetalbrain30.45
Fetalliver11.3
Fetallung29.85
GlobusPallidus9.35
Heart16.15
Hypothalamus27.25
Kidney8.65
Leukemia_chronicMyelogenousK-562124.7
Leukemia_promyelocytic-HL-6083.7
Leukemialymphoblastic(MOLT-4)33.75
Liver15.3
Lung38.8
Lymphnode42.6
Lymphoma_burkitts(Daudi)120.85
Lymphoma_burkitts(Raji)105.15
MedullaOblongata12.6
OccipitalLobe17.95
OlfactoryBulb16.55
Ovary10.05
Pancreas16.5
PancreaticIslet58
ParietalLobe13.55
Pituitary30.25
Placenta33.35
Pons9.4
PrefrontalCortex12
Prostate62.9
Salivarygland16.75
SkeletalMuscle23.45
Skin8.2
SmoothMuscle27.9
Spinalcord15.5
SubthalamicNucleus13.5
SuperiorCervicalGanglion9.4
TemporalLobe10.4
Testis57.85
TestisGermCell53.55
TestisIntersitial22.25
TestisLeydigCell22.85
TestisSeminiferousTubule23.15
Thalamus21.1
Thymus47.5
Thyroid71
Tongue20.65
Tonsil38.05
Trachea19.75
TrigeminalGanglion12.5
Uterus26.1
UterusCorpus8.95
WholeBlood12.3
Wholebrain24.75
colon16.9
pineal_day61.2
pineal_night84.16
retina30.8
small_intestine12.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1275_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.11 ± 0.49
Basal Forebrain3.82 ± 0.39
Basal Part of Pons3.78 ± 0.54
Cerebellar Cortex3.81 ± 0.51
Cerebellar Nuclei3.91 ± 0.46
Claustrum3.96 ± 0.82
Epithalamus3.65 ± 0.67
Frontal Lobe3.79 ± 0.55
Globus Pallidus4.34 ± 0.49
Hypothalamus3.61 ± 0.41
Insula3.79 ± 0.4
Limbic Lobe4.01 ± 0.42
Mesencephalon3.88 ± 0.6
Myelencephalon3.84 ± 0.6
Occipital Lobe4.08 ± 0.46
Parietal Lobe3.9 ± 0.52
Pontine Tegmentum3.86 ± 0.51
Striatum3.78 ± 0.5
Subthalamus3.52 ± 0.56
Temporal Lobe3.78 ± 0.49
Thalamus3.7 ± 0.48
White Matter4.48 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Polr3eCBCerebellum1.99
2.24
Polr3eCTXCerebral cortex1.77
1.15
Polr3eHIPHippocampal region10.98
9.73
Polr3eHPFHippocampal formation8.77
7.15
Polr3eHYHypothalamus2.24
1.74
Polr3eLSXLateral septal complex0.49
0.54
Polr3eMBMidbrain0.96
1.12
Polr3eMYMedulla9.79
14.61
Polr3eOLFOlfactory bulb7.05
4.62
Polr3ePPons2.85
3.62
Polr3ePALPallidum2.1
1.48
Polr3eRHPRetrohippocampal region3.68
2.5
Polr3esAMYStriatum-like amygdalar nuclei2.21
1.46
Polr3eSTRStriatum1.03
0.7
Polr3eSTRdStriatum dorsal region0.59
0.38
Polr3eSTRvStriatum ventral region2.97
1.88
Polr3eTHThalamus0.93
0.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000156 22 539 560 AAGTDSFNGHPPQGCASTPVAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved