AutismKB 2.0

Annotation Detail for N4BP2


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Basic Information Top
Gene Symbol:N4BP2 ( B3BP,FLJ10680,KIAA1413 )
Gene Full Name: NEDD4 binding protein 2
Band: 4p14
Quick LinksEntrez ID:55728; OMIM: NA; Uniprot ID:N4BP2_HUMAN; ENSEMBL ID: ENSG00000078177; HGNC ID: 29851
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus13 / 56401223
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult15 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal51 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung3 / 3369748
lymph0 / 442700 
lymph node1 / 9161010
mammary gland1 / 1532716
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate0 / 1893450 
salivary gland1 / 2015549
skin2 / 2105749
spleen2 / 5395237
stomach1 / 9661910
testis4 / 33044212
thymus5 / 8113161
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P222114
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.51 ± 0.49
Basal Forebrain5.64 ± 0.23
Basal Part of Pons4.91 ± 0.44
Cerebellar Cortex5.64 ± 0.31
Cerebellar Nuclei4.64 ± 0.53
Claustrum5.13 ± 0.93
Epithalamus5.92 ± 0.48
Frontal Lobe4.72 ± 0.53
Globus Pallidus5.01 ± 0.49
Hypothalamus5.76 ± 0.57
Insula5.41 ± 0.53
Limbic Lobe5.04 ± 0.67
Mesencephalon5.25 ± 0.63
Myelencephalon5.16 ± 0.57
Occipital Lobe5.86 ± 0.51
Parietal Lobe5.24 ± 0.46
Pontine Tegmentum5.21 ± 0.65
Striatum4.86 ± 0.5
Subthalamus4.69 ± 0.35
Temporal Lobe5.21 ± 0.5
Thalamus5 ± 0.4
White Matter4.94 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
B3bpCBCerebellum10.52
13.74
B3bpCTXCerebral cortex2.25
2.09
B3bpHIPHippocampal region7
7.24
B3bpHPFHippocampal formation6.46
6.25
B3bpHYHypothalamus8.29
6.07
B3bpLSXLateral septal complex6.47
4.44
B3bpMBMidbrain2.78
2.54
B3bpMYMedulla10.6
11.09
B3bpOLFOlfactory bulb9.48
7.59
B3bpPPons6.88
6.79
B3bpPALPallidum6.98
5.95
B3bpRHPRetrohippocampal region5.49
4.76
B3bpsAMYStriatum-like amygdalar nuclei22.74
16.25
B3bpSTRStriatum5.66
4.58
B3bpSTRdStriatum dorsal region1.46
1.58
B3bpSTRvStriatum ventral region11.39
8.53
B3bpTHThalamus1.93
1.89
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010895 15 827 841 LVNSVSVNTDCVQQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018