AutismKB 2.0

Annotation Detail for VPS35


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Basic Information Top
Gene Symbol:VPS35 ( DKFZp434E1211,DKFZp434P1672,FLJ10752,FLJ13588,FLJ20388,MEM3 )
Gene Full Name: vacuolar protein sorting 35 homolog (S. cerevisiae)
Band: 16q11.2
Quick LinksEntrez ID:55737; OMIM: 601501; Uniprot ID:VPS35_HUMAN; ENSEMBL ID: ENSG00000069329; HGNC ID: 13487
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst7 / 62319112
fetus130 / 564012230
neonate16 / 31097514
infant7 / 23620296
juvenile17 / 55556305
adult331 / 1939121170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma7 / 17475400
breast (mammary gland) tumor16 / 94178169
cervical tumor7 / 34366203
chondrosarcoma10 / 82823120
colorectal tumor12 / 114246105
esophageal tumor7 / 17290404
gastrointestinal tumor16 / 119369134
germ cell tumor80 / 263845303
glioma3 / 10688328
head and neck tumor16 / 136302117
kidney tumor15 / 68959217
leukemia17 / 95842177
liver tumor23 / 96359238
lung tumor12 / 103127116
lymphoma12 / 71755167
non-neoplasia15 / 97250154
normal706 / 3360307210
ovarian tumor5 / 7668265
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS24 / 125680190
prostate cancer20 / 102680194
retinoblastoma2 / 4635643
skin tumor17 / 124949136
soft tissue/muscle tissue tumor23 / 125191183
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites10 / 40015249
bladder8 / 29757268
blood21 / 123478170
bone10 / 71655139
bone marrow6 / 48801122
brain352 / 1100989319
cervix8 / 48171166
connective tissue20 / 149255133
ear3 / 16212185
embryonic tissue30 / 215722139
esophagus7 / 20209346
eye24 / 211054113
heart18 / 89626200
intestine36 / 234472153
kidney40 / 211777188
larynx4 / 24145165
liver32 / 207743154
lung55 / 336974163
lymph4 / 4427090
lymph node19 / 91610207
mammary gland30 / 153271195
mouth6 / 6705289
muscle3 / 10771527
nerve1 / 1576863
ovary6 / 10205158
pancreas26 / 214812121
parathyroid7 / 20539340
pharynx12 / 41328290
pituitary gland0 / 165850 
placenta38 / 280825135
prostate32 / 189345169
salivary gland1 / 2015549
skin53 / 210574251
spleen17 / 53952315
stomach13 / 96619134
testis136 / 330442411
thymus8 / 8113198
thyroid7 / 47473147
tonsil1 / 1699958
trachea15 / 52413286
umbilical cord2 / 13680146
uterus65 / 232878279
vascular16 / 51780308
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217727_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts611.5
Adipocyte128.6
AdrenalCortex82.2
Adrenalgland11.15
Amygdala538.15
Appendix43.2
AtrioventricularNode8.7
BDCA4+_DentriticCells539.5
Bonemarrow28
BronchialEpithelialCells634.8
CD105+_Endothelial422.6
CD14+_Monocytes796.8
CD19+_BCells(neg._sel.)375.25
CD33+_Myeloid865.35
CD34+841.6
CD4+_Tcells301.2
CD56+_NKCells407.3
CD71+_EarlyErythroid177.35
CD8+_Tcells235.55
CardiacMyocytes200.9
Caudatenucleus219.6
Cerebellum7.55
CerebellumPeduncles87.5
CiliaryGanglion87.3
CingulateCortex350.55
Colorectaladenocarcinoma121.05
DorsalRootGanglion139.55
FetalThyroid230.7
Fetalbrain357.15
Fetalliver125.3
Fetallung194.15
GlobusPallidus226.6
Heart7.05
Hypothalamus543.95
Kidney66.5
Leukemia_chronicMyelogenousK-562119.45
Leukemia_promyelocytic-HL-60285.6
Leukemialymphoblastic(MOLT-4)116.95
Liver10.6
Lung29.45
Lymphnode116.05
Lymphoma_burkitts(Daudi)293.95
Lymphoma_burkitts(Raji)200.25
MedullaOblongata308.8
OccipitalLobe347.3
OlfactoryBulb199.1
Ovary29.1
Pancreas107.5
PancreaticIslet148.9
ParietalLobe289.1
Pituitary224.35
Placenta167.85
Pons232.35
PrefrontalCortex490
Prostate181.85
Salivarygland68.5
SkeletalMuscle39.95
Skin32.7
SmoothMuscle289.4
Spinalcord200.9
SubthalamicNucleus333.3
SuperiorCervicalGanglion43.6
TemporalLobe249.7
Testis222.95
TestisGermCell487.55
TestisIntersitial241.75
TestisLeydigCell229.75
TestisSeminiferousTubule283.95
Thalamus418
Thymus160.25
Thyroid252.25
Tongue108
Tonsil224.85
Trachea140.95
TrigeminalGanglion63.35
Uterus156.7
UterusCorpus109.8
WholeBlood226.3
Wholebrain112.2
colon248.8
pineal_day613.74
pineal_night653.34
retina218.325
small_intestine376.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P270769
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.92 ± 0.31
Basal Forebrain11.15 ± 0.17
Basal Part of Pons11.6 ± 0.16
Cerebellar Cortex11.15 ± 0.15
Cerebellar Nuclei11.5 ± 0.31
Claustrum11.51 ± 0.32
Epithalamus11.57 ± 0.34
Frontal Lobe11.52 ± 0.26
Globus Pallidus10.75 ± 0.49
Hypothalamus11.72 ± 0.2
Insula11.42 ± 0.17
Limbic Lobe11.24 ± 0.44
Mesencephalon11.35 ± 0.41
Myelencephalon11.27 ± 0.42
Occipital Lobe10.87 ± 0.49
Parietal Lobe11.36 ± 0.36
Pontine Tegmentum11.31 ± 0.39
Striatum10.88 ± 0.43
Subthalamus11.81 ± 0.31
Temporal Lobe11.4 ± 0.31
Thalamus11.28 ± 0.26
White Matter10.57 ± 0.24
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000198 12 285 296 ACAELHQNVNVK Peptide Atlas
VPS35_HUMAN_0 0 0 0 ACAELHQNVNVK PRIDE
VPS35_HUMAN_0 0 0 0 FTLPPLVFAAYQLAFR PRIDE
VPS35_HUMAN_0 0 0 0 IFSFAHQTISALIK PRIDE
VPS35_HUMAN_0 0 0 0 IPVDTYNNILTVLK PRIDE
VPS35_HUMAN_0 0 0 0 LLKIPVDTYNNILTVLK PRIDE
VPS35_HUMAN_2 31 2 32 PTTQQSPQDEQEKLLDEAIQAVKVQSFQMKR PRIDE
VPS35_HUMAN_217 9 217 225 ILVGTNLVR PRIDE
VPS35_HUMAN_226 11 226 236 LSQLEGVNVER PRIDE
VPS35_HUMAN_239 15 239 253 QIVLTGILEQVVNCR PRIDE
VPS35_HUMAN_284 12 284 295 ACAELHQNVNVK PRIDE
VPS35_HUMAN_296 27 296 322 NIIIALIDRLALFAHREDGPGIPADIK PRIDE
VPS35_HUMAN_323 16 323 338 LFDIFSQQVATVIQSR PRIDE
VPS35_HUMAN_400 17 400 416 LLKIPVDTYNNILTVLK PRIDE
VPS35_HUMAN_403 14 403 416 IPVDTYNNILTVLK PRIDE
VPS35_HUMAN_419 14 419 432 HFHPLFEYFDYESR PRIDE
VPS35_HUMAN_45 10 45 54 HASNMLGELR PRIDE
VPS35_HUMAN_500 15 500 514 SEDPDQQYLILNTAR PRIDE
VPS35_HUMAN_503 12 503 514 PDQQYLILNTAR PRIDE
VPS35_HUMAN_524 18 524 541 IRFTLPPLVFAAYQLAFR PRIDE
VPS35_HUMAN_526 16 526 541 FTLPPLVFAAYQLAFR PRIDE
VPS35_HUMAN_90 17 90 106 VADLYELVQYAGNIIPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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